Doctor insights on:
Can Agent Orange Cause Diffuse Large B Cell Lymphoma
No one knows: Certainly some other cancers have been linked but as far as i know there is no direct linkage. On the other hand, herbicides have had an association with lymphoma and myeloma and agent orange is a "super herbicide". It is always hard to show a direct linkage. ...Read moreSee 1 more doctor answer
What is the association between lymphoma and hypothyroidism? Can agent orange cause hypothyroidism?
Lymphoma and thyroid: Hashimoto's thyroiditis is an immune attack on the thyroid which can over time provoke lymphoma through overstimulation of the lymph tissue in the area. Lymphoma can also be seen with other autoimmune conditions such as sjogren's syndrome, crohn's disease, common variable immunodeficiency, and rheumatoid arthritis. I couldn't find any medical reports linking agent orange and hypothyroidism. ...Read more
No: We can only guess what causes diffuse large b-cell lymphoma, but we know there are at least 3 genetic subtypes. See: http://www.bloodjournal.org/content/105/5/1851 This implies gene mutations are very important in this disease, as in most (if not all) blood borne malignancies. As far as anyone knows, Aleve (naproxen) PM (or any drug like it ) does not cause genetic mutation or clearly increase cancer risk. ...Read moreSee 1 more doctor answer
Yes: Agent orange is phenoxyl hercides chemically. Epidemiology study showed an association between such as exposure and non-hodgkin's lymphoma including folicular lymphoma. An interesting article publised in J Exp Med noted a drastic clonal expansion of t(14:18) B cells in patient's blood exposed to various pesticides. Chromosomal translocation (14:18) is a hallmark for follicular lymphoma. ...Read more
Fairly quickly: This is a very fast growing disease which in most cases has already caused some damage before it is discovered. It is important to quickly stage the disease and then begin treatment. Your oncologist will know how much time can pass before you start treatment. Everyone is different in this respect and sometimes life's issues (graduations, weddings) can be worked around..And sometimes not. ...Read moreSee 1 more doctor answer
My grand father (79 years) has been diagnosised with diffuse large "b" cell lymphoma, high grade. Please tell me this is which stage.Thnks.
More information?: Stage depends on location for non-hodgkin's lymphoma. How many lymph node groups were involved, where exactly they were located. Your doctor should be able to tell you the stage. ...Read more
R-CHOP: The most common regimen is r-chop (rituximab, cytoxan, adriamycin, (doxorubicin) vincristine, prednisone). Other options are epoch-r, a clinical trial. There are several regimens, but the most common regimen is r-chop. It also varies on the stage of the disease. Hope this helps. ...Read more
What is the best way to recover from low WBC after chemotherapy (r-cvp for stage 2 diffuse large b-cell lymphoma) for a very elderly (85y) patient?
It depends.: R-cvp is a relatively milder regimen and therefore it does not usually result in very low wbcs. In general, modest decrease in WBC is expected and is not associated with higher risk for infections unless WBC become very low with neutrophil count below 500. If this is the case, you doctor may decide to use a growth factor given after chemotherapy to stimulate your bone marrow to produced wbcs. ...Read more
Maybe: In general we don't think of diffuse large b cell lymphoma (dlbcl) effecting brain function. However, many patients tell us of symptoms of a "fog" like feeling either before treatment (disease-related?) or after ("chemobrain"). Reasons are likely multifactorial and can include stress, financial concerns, depression, and disease biology. This is being actively studied by a variety of groups. ...Read moreSee 1 more doctor answer
50%: However, there are numerous features about an individual lymphoma that point to worse or better survival for that individual. And survival is dependent on treatment as well; the use of the monoclonal antibody, rituximab, greatly impacts on survival. Finally, the medical community does not equate survival with cure, so we tend to talk about five year survival and ten year survival. ...Read more
Not a common term: Diffuse b cell lymphoma is by definition an aggressive lymphoma which has the ability to spread rapidly if not treated. It is a "bad actor". I assume this term may be referring to a lymphoma that has already spread a good deal before being diagnosed. Even so, these lymphomas are often treatable and can be cured in the majority of cases. ...Read moreSee 1 more doctor answer
It is quite good: These are fast growing lymphomas that respond well to modern chemotherapy. Your doctor can tell you what risk category you fall into based on your age and several aspects of your tumor which include it's stage at presentation. Outside of this, staying on time with chemotherapy and not having to reduce the intended dose lead to the highest cure rates. The majority of patients can be cured. ...Read moreSee 2 more doctor answers
Probably not but...: Agent Orange contains dioxin, a toxic chemical proven to cause many serious illnesses. Muscular dystrophy is something people are born with. Agent Orange may cause Muscular dystrophy in the children of those exposed to it but isn't known to cause it directly in those exposed. See http://www.veteranshealth.org/Vietnam/AO.html A holistic/integrative physician can evaluate/treat illness from toxins. ...Read more
I was vietnam between 1965 & 1966 and exposed to "agent orange"-have had tingling & burning , numbing in my feet, could agent cause this all these yr'.?
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