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Doctor insights on: Can Acute Intermittent Porphyria Cause Kidney Failure

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Can acute intermittent porphyria cause mental illness or psychosis?

Can acute intermittent porphyria cause mental illness or psychosis?

Short answer- YES: The diagnosis of AIP should always be in the differential diagnosis of a person who becomes psychotic& who fits a certain clinical profile which usually includes vague GI symptoms and abdominal pain unexplained neuropathy, and other characteristic symptoms. Feel free to write me more questions on this topic and I'll be happy to answer: www.healthtap.com/drsaghafi ...Read more

Dr. Aletha Tippett
89 doctors shared insights

Porphyria (Definition)

The porphyrias are metabolic disorders caused by abnormalities in the synthesis of heme, the portion of hemoglobin which carries the iron inside red blood cells. The manifestations of porphyria vary considerably depending on the mutation involved, ranging from light sensitivity to liver failure to nerve damage to bouts of terrible pain. Special testing is required to ...Read more


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In regards to acute intermittent porphyria, what causes abdominal pain?

In regards to acute intermittent porphyria, what causes abdominal pain?

Great question: AIP causes an axonal neuropathy which starts in proximal arms but spreads throughout limbs, and likely throughout the body. During the cramping attacks, there is an increase in delta-aminolevulinic acid and porphobiilnogen which likely stimulates abnormal nerve activity within the gut. ...Read more

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Do you have to have abdominal pain if you have acute intermittent porphyria? What are all the symptoms?

Do you have to have abdominal pain if you have acute intermittent porphyria? What are all the symptoms?

It's a mix: Acute intermitent porphyria should be suspected when mental illness, bad constipation, abdominal pain, low sodium, or a neuropathy are found without obvious explanation. Any one of these should trigger suspicion. The tests are often done wrong because of problems with collecting the specimens. ...Read more

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Please tell me what can cause acute kidney failure?

Please tell me what can cause acute kidney failure?

Acute renal failure: Acute renal failure (ARF) can arise from low blood pressure, from a loss of blood or sepsis, causing acute tubular necrosis of the kidneys. Other causes are nephrotoxic agents, such as nsaid's. And urinary obstruction. Rhabdomyolysis, multiple myeloma, and acutely elevated uric acid levels to cancer treating agents can cause arf. Most ARF cases can recover their kidney function once treated. ...Read more

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What usually causes acute kidney failure in the elderly?

What usually causes acute kidney failure in the elderly?

Meds and Dehydration: Acute kidney failure occurs predominantly from newly prescribed medications like a diuretic (hctz (hydrochlorothiazide) or lasix) or from certain anti-hypertensive medications like an ace or arb (enalapril or cozaar). Also akf occurs in the elderly if they do not get enough water intake especially in warm environments when they sweat a lot. ...Read more

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Are there over-the-counter medicine that cause acute kidney failure?

Are there over-the-counter medicine that cause acute kidney failure?

Yes: Nonsteroidal anti inflammatory drugs like Ibuprofen can trigger kidney injury especially with fever, dehydration and the presence of other drugs or illnesses. ...Read more

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Is there an over-the-counter medicine that can cause acute kidney failure?

Is there an over-the-counter medicine that can cause acute kidney failure?

Yes: Nonsteroidal anti inflammatory drugs like Ibuprofen can trigger kidney injury especially with fever, dehydration and the presence of other drugs or illnesses. ...Read more

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Acute kidney failure caused by meds. Stopped meds and got better. Creatin level falling 1.9-1.7-1.6-1.3 at last test. Is this good?

Acute kidney  failure caused by meds.  Stopped meds and got better.  Creatin level falling 1.9-1.7-1.6-1.3 at last test.  Is this good?

Yes: It appears your renal function is improving with each subsequent test. Many medications are metabolized through the kidneys and have the potential to cause renal issues. It appears your renal problem was diagnosed and treated appropriately and you are on the road to recovery. Best wishes. ...Read more

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What causes acute kidney failure?

What causes acute kidney failure?

Toxic insults: Low blood pressure, interruption of blood flow, obstruction of urine flow, drug allergies, toxic drugs, autoimmune disease, heart failure, chronic liver disease, sepsis, underlying problems such as diabetes and myeloma increase the chance for renal failure. There are many causes, most are evident upon inspection of the patient, this requires expert attention and action to reverse the process. ...Read more

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Kidney (Definition)

The kidneys are paired organs that lie on either side of the vertebral column. Part of their critical functions include the excretion of urine and removal of nitrogenous wastes products from the blood. They regulate acid-base, electrolyte, fluid balance and blood pressure. Through hormonal signals, the kidneys control the ...Read more


Dr. Tarek Naguib
587 doctors shared insights

Kidney Failure (Definition)

The kidneys do several tasks. Dialysis is necessary when one or more of the following occur, that can't be remedied or palliated with medications: 1. Insufficient clearance of daily toxins in food and metabolic waste 2. Insufficient clearance of excess water 3. Dangerous electrolyte imbalance, ...Read more