Doctor insights on:
Can A Person Wtih Alpha Thalassemia Trait Donate Blood
Maybe: A person with Alpha thalassemia trait may be not anemic or mildly anemic. If he is not anemic, he can be a blood donor. However, since he has a more difficult time making hemoglobin (to make new red blood cells), he may not wish to be a blood donor. ...Read more
My 3yr old daughter has an Alpha thalassemia trait which I found she inherited from me. We're the same blood type could that have been the reason?
Inheritance: Both are inherited characteristics and are simply due to the fact that you are her mother (and were also affected by the father)...they aren't "linked" together. Thalasemias are due to production defects in hemoglobin, the oxygen carrying part of your red blood cells. Blood type (A, B, O) is due to carbohydrate groups on the red cells. Whichever type you have is your blood type. ...Read more
Safe if necessary: Blood transfusions are given only when necessary especially in the younger population or blood disorders. Transfusions are necessary for major bleeding resulting in shock, low blood pressures, or continued blood loss. All transfusions are screened and safe but there is always a 1-3% risk of a clerical error. Pts. With blood disorders face increased risk of blood transfusion reactions. ...Read more
No: People with Alpha thalassemia trait are similar to regular people. Some Alpha thal. Trait persons are mildly anemic, but the anemia is not enough to cause symptoms. A few people may be anemic enough to feel tired or have pallor (pale appearance). Intestinal problems, and other medical problems, can occur just as they occur in non-thalassemic persons. ...Read more
Not quite: Normal people have 4 Alpha globulin genes. Mutations in 1, 2, 3, or all 4 of the genes cause the 4 levels of Alpha thalassemia. One mutation = silent carrier (no symptoms), 2 mutat. = Alpha trait (mild anemia), 3 mutat. = HGB h disease (anemia sometimes needing transfusions), 4 mutat. = bart's disease (fatal before birth in almost all cases; lifelong transfusions needed to survive if born alive). ...Read more
Inherited defect: Our regular hemoglobin is composed of Alpha and beta chains that come together to form working hemaglobin. Alpha thalassemia trait occurs when a person inherits a defective Alpha chain gene from one parent & a normal Alpha chain gene from the other. This causes some reduction in Alpha chain production with resulting mild anemia. ...Read more
I have alpha thalassemia trait. Are there programs I can do to train myself to run a race without passing out or getting too fatigued?
Like normal...: A person with Alpha thalassemia trait (two mutated Alpha chain genes and two normal) usually has no symptoms. You may be slightly anemic, but this should not affect your exercise performance. Perhaps if you were running ultra marathons in the alps you might see an effect, but otherwise you should be able to train normally and do great. Regardless of Alpha thal trait, stay hydrated. ...Read more
I feel light headed and dizzy often. Much worse during inactive contraception pills. I have PCOS and alpha thalassemia trait.
PCOS: anemia?: Since bleeding occurs at the time of the "inactive" oral contraceptive pills, and you have a "thalassemia trait", you may be anemic, and the symptoms may be related to a low hemoglobin content. This may need investigation by your healthcare provider, as there are other causes for your symptoms, which are probably not related to your birth control pill cycle. ...Read more
Possible: It mainly depends on the status of anemia at the time when the individual with Alpha thalassemia minor present at donation (hemoglobin higher than 12.5 or hematocrit at 38 or higher). You also need to comply to other criteria as qualified blood donor which vary between states in the us. ...Read more
I have trait for alpha thalassemia. My iron is high a lot; are there any other elements, minerals, or compounds I should watch out for?
Yes: Hematologists (blood specialists) evaluate persons with both sickle cell trait and Alpha thalassemia disease. The sickling should not be a problem, because the person is only sickle trait, and Alpha thal. Mutations seem to lessen the tendency of blood cells to sickle from the sickle cell mutation. Persons with both sickle trait and Alpha thal. Trait probably won't have symptoms needing treatment. ...Read more
TTC&RE done several blood tests. I am negative but inconclusive to alpha thalassemia. How? DH tested for Hgb electrophoresis. Why? Is it serious? What next?
Genetics consult: If you are trying to have a baby or will do so in the future, tis important to know what the chances are for the baby to have the disease. If you are both carriers, then there is a higher risk for the baby to have the disease. You said he was tested but never said if he is positive for carrier state or does he have it? Talk to a geneticist, there's always one associated with children's hosp ...Read more
My child tested neg. For alpha thalassemia during her newborn screening but pos. Mths after a blood transfusion? Was the donor's blood still present?
Repeat it: There's always the possibility of lab error. If this is important, please do retest. ...Read more
Yes: As long as you meet the donor requirements for donation, then having beta-thalassemia is not a criterion for exclusion. However, females with beta-thalassemia trait rarely meet the donor criterion of hemoglobin of 12 gm/dl and are frequently deferred. ...Read more
If anemic, no: The red cross won't let people who are anemic donate blood. People are checked for anemia at their screening for blood donation, and if your hemoglobin is less than 12.5 they will not allow you to donate blood. Not everyone with beta thalassemia trait is anemic, so there is a chance that you may pass the screening. However, if you know that you often have a low hemoglobin, expect to be turned away. ...Read more
Maybe: With thalassemia trait your hemoglobin level may be too low to qualify for donating blood. The trait does not disqualify you based on listings of various donation center sites. You do have to have to meat other age and health requirements. Look up some info at the carter blood care center site or the american red cross. ...Read more
If someone with thalassemia trait were to donate blood, would the recipients of that blood be carriers?
No: The donated blood does not alter the recipients system in the long term. The blood cells each have a lifespan approaching 90-100 days after release, then they are broken down in the body and recycled. Blood donation helps a patient catch up with blood losses in the short term and provide stability of the system while it heals. ...Read more
Yes: Marriage is no problem. Getting pregnant, however, may not be recommended if they have moderate or severe thalassemia. If they have only "trait", they will be fine if their children only inherit "no trait" or "trait from either mom or dad". If a child inherits "trait" from both mom and dad, the child might have a problem. A geneticist and hematologist can give more details for individual cases. ...Read more
Family history: Thalassemia is a genetic disease of the hemoglobin molecule and so only occurs through inheritance. A mutation in this gene is especially prevalent in persons of african, asian, middle eastern or mediterranean descent. Individuals with only one mutation of the gene will be asymptomatic, so genetic screening is necessary to precisely determine risk. ...Read more
Of course you can: A person can marry anyone they like. From a thalassemia perspective, and assuming your Alpha thal trait is in cis, your child has a 50/50 chance of being Alpha thal trait vs. Normal and a 50/50 chance of being beta thal trait vs. Normal. Given there is consideration of inheriting two distinct trait states, it would be prudent to sit with a genetic counselor to understand the implications clearly. ...Read more
Traits, yes: Because the Alpha and beta thalassemia gene mutations are common, it is possible for a baby to inherit one from mom and another from dad. The child could be "trait" in both Alpha and beta, or less likely, be "disease" in one and "trait" in the other. It is hard to imagine being "disease" in both and still survive. ...Read more
No: I don't believe it's compatible with life ...Read more
Uncertain: Hemoglobin j is actually a group of at least 50 variants that share a common rapid mobility in electrophoresis and ief. Mutations can occur in either the Alpha or beta chains. Most oftenpresent in the heterozygous state and clinically silent. Because of this, and the limited information about them in relation to other abnormal hemoglobins, a relationship with thalassemia syndromes is not known. ...Read more
None to severe/fatal: Alpha thalassemia signs and symptoms: silent carriers have no signs/symptoms (and live a normal life); Alpha trait has mild anemia (and generally live a normal life); HGB h (moderate) may have weakness, pallor, less growth, and need some transfusions; bart's disease (severe) is usually fatal before birth. ...Read more
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