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Doctor insights on: Can A Person With Alpha Thalassemia Marry Someone With Beta Thalassemia Safely

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Can a person with alpha thalassemia marry someone with beta thalassemia safely?

Can a person with alpha thalassemia marry someone with beta thalassemia safely?

Yes: Marriage is no problem. Getting pregnant, however, may not be recommended if they have moderate or severe thalassemia. If they have only "trait", they will be fine if their children only inherit "no trait" or "trait from either mom or dad". If a child inherits "trait" from both mom and dad, the child might have a problem. A geneticist and hematologist can give more details for individual cases. ...Read more

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Dr. Ana Adelstein
31 doctors shared insights

Hemoglobin H Disease (Definition)

Hemoglobin is composed of alpha and beta chains. In hemoglobin H disease, the beta chains are normal but there is little or ...Read more


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Can a person wtih alpha thalassemia trait donate blood?

Can a person wtih alpha thalassemia trait donate blood?

Maybe: A person with Alpha thalassemia trait may be not anemic or mildly anemic. If he is not anemic, he can be a blood donor. However, since he has a more difficult time making hemoglobin (to make new red blood cells), he may not wish to be a blood donor. ...Read more

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Can a normal & healthy person may marry with e beta thalassemia , safely?????

Can a normal & healthy person may marry with e beta thalassemia , safely?????

Yes: If you do not carry the gene in any way, any children will be carriers. HbgE/beta thalassemia is a disease that can be mild or severe. The best way to ease your mind is to seek genetic counseling. All the best. ...Read more

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Can a person with beta thalassemia trait be a blood donor?

Can a person with beta thalassemia trait be a blood donor?

Yes, but unlikely: A person with beta thalassemia trait may be not anemic or mildly anemic. If he is not anemic, he can be a blood donor. However, since he has a more difficult time making hemoglobin (to make new red blood cells), he may not wish to be a blood donor. ...Read more

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Are blood transfusions after delivery be safe for someone with alpha thalassemia trait?

Are blood transfusions after delivery be safe for someone with alpha thalassemia trait?

Safe if necessary: Blood transfusions are given only when necessary especially in the younger population or blood disorders. Transfusions are necessary for major bleeding resulting in shock, low blood pressures, or continued blood loss. All transfusions are screened and safe but there is always a 1-3% risk of a clerical error. Pts. With blood disorders face increased risk of blood transfusion reactions. ...Read more

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Can a man with AC genotype marry a woman with as genotype. Both of them have o+ blood group. Thank you?

Can a man with AC genotype marry a woman with as genotype. Both of  them have o+ blood group. Thank you?

Not sure. : My understanding is that marriages are regulated in nigeria based on sickle cell genotype. This is not the case in the United States. I thought that the restriction of marriage partners was based on the presence of sickle gene (as or ss). But this would be a question for a court magistrate in nigeria. Certainly sc disease, which would be possible, can be a troublesome disease. Good luck. ...Read more

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Can an alpha thalassemia carrier marry a beta thalassemia carrier?

Can an alpha thalassemia carrier marry a beta thalassemia carrier?

Of course you can: A person can marry anyone they like. From a thalassemia perspective, and assuming your Alpha thal trait is in cis, your child has a 50/50 chance of being Alpha thal trait vs. Normal and a 50/50 chance of being beta thal trait vs. Normal. Given there is consideration of inheriting two distinct trait states, it would be prudent to sit with a genetic counselor to understand the implications clearly. ...Read more

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Can a father with normal blood and a mother with sickle cell trait have a child with sickle cell anemia?

Can a father with normal blood and a mother with sickle cell trait have a child with sickle cell anemia?

NO: To simplify- providing that the father has a completely normal blood - ( no other type of congenital/hereditary bood disorder-like thalasemia minor, hemoglobin c disease etc) - the baby will have 50% risk to have sickle cell trait-but the baby will not have sickle cell anemia. ...Read more

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Can a female with Hb H disease marry someone with beta thalassemia trait? What are the possible results in terms of genetics percentages?

Sure: Anybody can marry anybody. Since HgbH disease involves the alpha genes and beta thal minor involves the beta genes, I would not be concerned. However, you might do well to be certain that neither partner carries the other person's trait as well masked by what's already diagnosed. Sit down with a competent clinical geneticist. ...Read more

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Will there be immunocompromise with alpha thalassemia?

Not directly.: Thalassemia affects red cells while immunity is related to white cells. However, with severe thalassemia, life-saving treatment may cause immunocompromise as a side effect. ...Read more

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Is there a treatment available for people with sickle cell trait and alpha thalassemia?

Is there a treatment available for people with sickle cell trait and alpha thalassemia?

Yes: Hematologists (blood specialists) evaluate persons with both sickle cell trait and Alpha thalassemia disease. The sickling should not be a problem, because the person is only sickle trait, and Alpha thal. Mutations seem to lessen the tendency of blood cells to sickle from the sickle cell mutation. Persons with both sickle trait and Alpha thal. Trait probably won't have symptoms needing treatment. ...Read more

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Can a man with AC genotype marry a woman with AC genotype. Thank you?

Can a man with AC genotype marry a woman with AC genotype. Thank you?

Yes: I'm assuming that you are talking about the genetics of hemoglobin, so we'd be talking about individuals with a gene for hemoglobin a (normal hemoglobin) and hemoglobin c (more fragile hemoglobin). The possibilities for your offspring would be 25% aa; 50% ac; 25% cc (hemoglobin c). If you want more information, genetic counselors can talk to you at length about the possibilities. ...Read more

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If the mother is alpha and father is beta thalassemic, can their children be free from thalassemia?

Only if traits: If mom and dad are both thalassemia trait, not "major", then mom and dad most likely each have one normal gene. The child who inherits the normal gene from mom and from dad, will end up with 2 normal genes and no thalassemia! ...Read more

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What to do about alpha thalassemia trait (minor) with asthama?

What to do about alpha thalassemia trait (minor) with asthama?

Nothing: Alpha thal minor is uttery trivial. Manage your asthma and if you choose to marry, be aware of your alpha-thal and the risk that marrying someone else with the same condition puts your children at risk. ...Read more

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Can you tell me how is the gene for alpha thalassemia an adaptive trait?

Can you tell me how is the gene for alpha thalassemia an adaptive trait?

Adaptive?: Not certain what you mean. Alpha Thal trait is a genetic--hereditary finding, which was shared with you by either your Mom or Dad. It is not adaptive as sickle cell trai/disease to help prevent malaria, to my knowledge. ...Read more

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Can a person with hemolytic anemia donate blood?

Unwise.: If you have hemolytic anemia, you probably need to keep all the blood cells you've got! there are many different causes for hemolytic anemia. Check with your local red cross to find out if you qualify. ...Read more

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Is it possible to have both alpha thalassemia and beta thalassemia?

Traits, yes: Because the Alpha and beta thalassemia gene mutations are common, it is possible for a baby to inherit one from mom and another from dad. The child could be "trait" in both Alpha and beta, or less likely, be "disease" in one and "trait" in the other. It is hard to imagine being "disease" in both and still survive. ...Read more

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Dr. Chad Levitt
33 doctors shared insights

Alpha Thalassemia (Definition)

A blood disorder that reduces the production of hemoglobin (the protein in red blood cells that carries oxygen to ...Read more


Dr. Craig MacArthur
67 doctors shared insights

Beta Thalassemia (Definition)

A blood disorder that reduces ...Read more