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Doctor insights on: Can A Person With Alpha Thalassemia Marry Someone With Beta Thalassemia Safely

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Can a person with alpha thalassemia marry someone with beta thalassemia safely?

Can a person with alpha thalassemia marry someone with beta thalassemia safely?

Yes: Marriage is no problem. Getting pregnant, however, may not be recommended if they have moderate or severe thalassemia. If they have only "trait", they will be fine if their children only inherit "no trait" or "trait from either mom or dad". If a child inherits "trait" from both mom and dad, the child might have a problem. A geneticist and hematologist can give more details for individual cases. ...Read more

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Dr. William Singer
30 doctors shared insights

Hemoglobin H Disease (Definition)

Hemoglobin H disease (alpha thalassemia) is a blood disease where one of the molecules that helps carry oxygen in the blood cell is missing. This causes a ...Read more


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Can an alpha thalassemia carrier marry a beta thalassemia carrier?

Of course you can: A person can marry anyone they like. From a thalassemia perspective, and assuming your Alpha thal trait is in cis, your child has a 50/50 chance of being Alpha thal trait vs. Normal and a 50/50 chance of being beta thal trait vs. Normal. Given there is consideration of inheriting two distinct trait states, it would be prudent to sit with a genetic counselor to understand the implications clearly. ...Read more

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Is it possible to have both alpha thalassemia and beta thalassemia?

Traits, yes: Because the Alpha and beta thalassemia gene mutations are common, it is possible for a baby to inherit one from mom and another from dad. The child could be "trait" in both Alpha and beta, or less likely, be "disease" in one and "trait" in the other. It is hard to imagine being "disease" in both and still survive. ...Read more

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What is the difference between alpha and beta thalassemia? are both the symptoms the same?

What is the difference between alpha and beta thalassemia?  are both the symptoms the same?

Similar but differen: Alpha and beta thalassemia are distinct and different disorders since they diminish the production of distinct and different globin polypeptide chains and particularly in the homozygous state that has distinct and different consequences. Alpha and Beta Thal minor are similar Alpha Thal major is not compatable with life and results in miscarriage. Beta Thal major requires prolonged treatments etc. ...Read more

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Should you go ahead and get the h1n1 vaccine for your child if they have alpha beta thalassemia minor?

Should you go ahead and get the h1n1 vaccine for your child if they have alpha beta thalassemia minor?

Yes: Thalassemia minor is not a problem with any of the routine childhood or adult vaccinations. The vaccine benefits, and any uncommon side effects, should be the same in normal people as in thalassemia carriers. ...Read more

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Can a person wtih alpha thalassemia trait donate blood?

Can a person wtih alpha thalassemia trait donate blood?

Maybe: A person with Alpha thalassemia trait may be not anemic or mildly anemic. If he is not anemic, he can be a blood donor. However, since he has a more difficult time making hemoglobin (to make new red blood cells), he may not wish to be a blood donor. ...Read more

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How was alpha thalassemia named?

Conventional: As scientists investigated hemoglobin, the complicated compound in red blood cells that carries oxygen, they learned that it was made up of 5 parts; 4 of these are 2 copies each of 2 different proteins. They named these Alpha chains and beta chains. If you inherit a condition where the Alpha chains are produced in smaller amounts than normal, you have Alpha thalassemia. ...Read more

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Can alpha thalassemia be dominant?

Not quite: People normally have 4 Alpha globulin genes. A mutation in 1, 2, 3, or all 4 genes leads to the 4 levels of Alpha thalassemia. The genetics of the disorder is not all-or-none, not dominant-recessive. Instead, the more mutations, the worse the disease. One mutation = silent carrier (no symptoms), 2 muta. = Alpha trait (mild symptoms), 3 muta. = HGB h (moderate symptoms), 4 muta. = bart's (deaths). ...Read more

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What is alpha thalassemia disorder?

Hemoglobin problem: Alpha thal is caused by mutations that effect the production of a part of the hemoglobin molecule (Alpha chain). There are 4 genes involved in this production. Mutations can occur in 1 to 4 of these genes. The disease is more problematic the more genes are mutated. This disease is inherited from parents. ...Read more

Dr. Michael Engel
270 doctors shared insights

Thalassemia (Definition)

Thalassemia is sever anemia,it ...Read more