Doctor insights on:
Can A Person With Alpha Thalassemia Marry Someone With Beta Thalassemia Safely
Yes: Marriage is no problem. Getting pregnant, however, may not be recommended if they have moderate or severe thalassemia. If they have only "trait", they will be fine if their children only inherit "no trait" or "trait from either mom or dad". If a child inherits "trait" from both mom and dad, the child might have a problem. A geneticist and hematologist can give more details for individual cases. ...Read moreSee 1 more doctor answer
Yes, but unlikely: A person with beta thalassemia trait may be not anemic or mildly anemic. If he is not anemic, he can be a blood donor. However, since he has a more difficult time making hemoglobin (to make new red blood cells), he may not wish to be a blood donor. ...Read moreSee 1 more doctor answer
Safe if necessary: Blood transfusions are given only when necessary especially in the younger population or blood disorders. Transfusions are necessary for major bleeding resulting in shock, low blood pressures, or continued blood loss. All transfusions are screened and safe but there is always a 1-3% risk of a clerical error. Pts. With blood disorders face increased risk of blood transfusion reactions. ...Read moreSee 1 more doctor answer
Can a man with AC genotype marry a woman with as genotype. Both of them have o+ blood group. Thank you?
Not sure. : My understanding is that marriages are regulated in nigeria based on sickle cell genotype. This is not the case in the United States. I thought that the restriction of marriage partners was based on the presence of sickle gene (as or ss). But this would be a question for a court magistrate in nigeria. Certainly sc disease, which would be possible, can be a troublesome disease. Good luck. ...Read more
Of course: It's always wise to stay well-hydrated if you have sickle-trait. ...Read more
Of course you can: A person can marry anyone they like. From a thalassemia perspective, and assuming your Alpha thal trait is in cis, your child has a 50/50 chance of being Alpha thal trait vs. Normal and a 50/50 chance of being beta thal trait vs. Normal. Given there is consideration of inheriting two distinct trait states, it would be prudent to sit with a genetic counselor to understand the implications clearly. ...Read more
Can a father with normal blood and a mother with sickle cell trait have a child with sickle cell anemia?
Yes!: Different diseases!Get a more detailed answer ›
Can a female with Hb H disease marry someone with beta thalassemia trait? What are the possible results in terms of genetics percentages?
Sure: Anybody can marry anybody. Since HgbH disease involves the alpha genes and beta thal minor involves the beta genes, I would not be concerned. However, you might do well to be certain that neither partner carries the other person's trait as well masked by what's already diagnosed. Sit down with a competent clinical geneticist. ...Read more
Yes: Hematologists (blood specialists) evaluate persons with both sickle cell trait and Alpha thalassemia disease. The sickling should not be a problem, because the person is only sickle trait, and Alpha thal. Mutations seem to lessen the tendency of blood cells to sickle from the sickle cell mutation. Persons with both sickle trait and Alpha thal. Trait probably won't have symptoms needing treatment. ...Read moreSee 1 more doctor answer
Yes: I'm assuming that you are talking about the genetics of hemoglobin, so we'd be talking about individuals with a gene for hemoglobin a (normal hemoglobin) and hemoglobin c (more fragile hemoglobin). The possibilities for your offspring would be 25% aa; 50% ac; 25% cc (hemoglobin c). If you want more information, genetic counselors can talk to you at length about the possibilities. ...Read more
Traits, yes: Because the Alpha and beta thalassemia gene mutations are common, it is possible for a baby to inherit one from mom and another from dad. The child could be "trait" in both Alpha and beta, or less likely, be "disease" in one and "trait" in the other. It is hard to imagine being "disease" in both and still survive. ...Read moreSee 1 more doctor answer
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