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Can A Ca 125 Test Have A False Negative
Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?
Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normalSee 1 more doctor answer
Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more
Yes: Fibroids, benign cysts, endometriomas, and endometriosis can all result in a positive ca-125 test. Ca-125 is not a good screening test for ovarian cancer because there are so many causes of false positives. And furthermore, 50% of st 1 ovarian cancer may have a negative ca-125. Nonetheless, if you have a positive ca-125 and an ovarian cyst, it will probably need to be explored.
I had a ca 125 test done. Came back at 66 (no history of cancer). Ultrasound normal. Dr. Says no further evaluation needed. Is this true? I am 45
I had a ca 125 test done (no previous history of cancer)that came back as a 66. Ultrasound came back normal. Dr. Said no further evaluation is needed. True?
A CA 125: Test should never be ordered out of the blue, especially in a young woman with no cancer history. It increases the cost of health care, leads to unnecessary testing and worry. Despite good intent, this is bad practice.
Screening? No: Ca 125 is not a screening test. It can be elevated for reasons other than cancer. It should be used for follow up of certain cancers ie ovarian cancer. Even then, it is done periodically as part of surveillance strategy. Also used to help the clinician decide if a patient who is on chemotherapy is responding or not & some oncologists obtain them per 'cycle' of chemotherapy i.e. Every 3-4 wks.
Need for: Investigation. An elevated CA 125 does not necessarily mean cancer. All is suggests is that further investigation is needed. Consult this site for more info. Http://www. Nlm. Nih. Gov/medlineplus/ency/article/007217.htm
CA-125: This marker is elevated significantly at this value. It's greatest specificity for ovarian cancer is in post-menopausal women, but a variety of things that irritate the lining of the abdomen and even chest, can elevate it mildly. So things like appendicitis, endometriosis, and even diverticulosis can also result in high levels. But, getting checked out for what is behind this is a good idea.
Yes and No: Ca-125 is a test for follow-up after diagnosis and with the treatment of ovarian cancer. It is elevated in many other diseases. The test should not be used for a fishing expedition because it would be misleading and concerning for a patient like you. Why was the test done in the first place? Do you have cancer? In any case a 25 level could be normal? What was the normal range. In the lab?
Not a lot: This test can be elevated for several reasons: heart failure, ovarian cancer, and multiple other causes. Without a diagnosis of ovarian cancer all it means is there are a lot of questions. This test should not be ordered without a diagnosis or a very high suspicion of ovarian cancer. Hope this helps.See 1 more doctor answer
Not a diagnostic: Marker for cancer. Ca 125 is not a good test for making a diagnois of cancer. It is more useful for monitoring the course of a cancer associated with elevated ca 125 levels.
Not always.: If this test is high, it could mean endometrial cancer, fallopian tube cancer, lung cancer, breast cancer and gastrointestinal cancer. This can also indicate benign conditions, like endometriosis, other ovary disorders, and pregnancy, as well as any inflammatory condition in the abdiminal area. This is a big reason why it is used with other tests in evaluation and to follow treatment response.
Yes: Many lab tests are done in a fasting state, however, ca-125 is not affected by eating. Due to variations from lab to lab, it is important to have the test in the same level for follow-up studies.See 2 more doctor answers
No concern: Cysts of the ovary are common. If they are not complex but greater than 5cm, . Removal suggested under 5 cm can be watched. Ca 125 isa carbohydrate marker noted in tumors and inflammatory conditions. Since it is elevated in inflammatory pelvic disease it has no importance in benign disease. And can only be used for monitoring.
What to do if my friend recently found out that she had cysts in her ovaries, and had a ca125 test.?
Watch: Cysts in ovaries not uncommon and can be defined as simple or complex or even converting by a solid component. Ca125 means Carbohydrate antibody 125. Sugar markers like Ca125, Ca 19.9 Ca 17.1a have no diagnositic capabilities since they are elevated in inflammatory conditions. Ca monclonals can only be measured safely in known conditions of cancer to see progression or not.
Measures a protein: The ca-125 test is a blood test that detects a protein in the blood that is produced by malignant ovarian cells. It is used to help determine if an ovarian cancer patient has had a relapse, or to help differentiate a cyst found by sonogram or ct. The most important point: it should never be used as a yearly screening test, and should not be requested by patients as a screening test.
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