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Doctor insights on: Can A Ca 125 Test Have A False Negative

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Dr. Jane Van Dis Dr. Van Dis
Obstetrics & Gynecology
14 years in practice
Sanford School of Medicine of the University of South Dakota
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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal

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Dr. Julie Abbott
127 Doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


Dr. Katherine Sutherland Dr. Sutherland
Gynecology
39 years in practice
Stanford University School of Medicine
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Can a fibroid and a cyst come up on a ca 125 test?

Yes: Fibroids, benign cysts, endometriomas, and endometriosis can all result in a positive ca-125 test. Ca-125 is not a good screening test for ovarian cancer because there are so many causes of false positives. And furthermore, 50% of st 1 ovarian cancer may have a negative ca-125. Nonetheless, if you have a positive ca-125 and an ovarian cyst, it will probably need to be explored.

Dr. Richard Orr Dr. Orr
Surgery - Oncology
40 years in practice
University of South Florida College of Medicine
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Can an ovarian cyst raise a ca-125 test?

Yes: Many benign conditions can cause a mild to moderate elevation in ca-125. Talk it over with your doctor.

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Dr. Christian Schultheis Dr. Schultheis
Internal Medicine - Hematology & Oncology
20 years in practice
American University of the Caribbean
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I had a ca 125 test done. Came back at 66 (no history of cancer). Ultrasound normal. Dr. Says no further evaluation needed. Is this true? I am 45

Agree: You should have never had that test done (ca-125) without a diagnosis of ovarian cancer. It is a nonspecific test. But I agree, no further testing necessary. Routine follow up with your pcp and gynecologist. Hope this helps.

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Dr. Andrew Turrisi Dr. Turrisi
Radiation Oncology
43 years in practice
Georgetown University School of Medicine
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I had a ca 125 test done (no previous history of cancer)that came back as a 66. Ultrasound came back normal. Dr. Said no further evaluation is needed. True?

I had a ca 125 test done (no previous history of cancer)that came back as a 66. Ultrasound came back normal. Dr. Said no further evaluation is needed. True?

A CA 125: Test should never be ordered out of the blue, especially in a young woman with no cancer history. It increases the cost of health care, leads to unnecessary testing and worry. Despite good intent, this is bad practice.

Dr. Gurmukh Singh Dr. Singh
Pathology
45 years in practice
University of Pune, Armed Forces Medical College
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Certain food affect ca125 tests?

Not likely: Ca 125 test looks for a particular glycoprotein in blood and diet is not likely to affect the results.

Dr. Mazen Ghani Dr. Ghani
Radiology
20 years in practice
Central University of the East School of Medicine (UCE)
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What is the ca-125 test?

What is the ca-125 test?

CA-125: Cancer antigen 125 (ca-125) is a protein found on the surface of many ovarian cancer cells. It also can be found in other cancers and in small amounts in normal tissue. A ca-125 test measures the amount of this protein in the blood and can be used as a tumor marker.

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Dr. Hamidreza Sanatinia Dr. Sanatinia
Internal Medicine - Hematology & Oncology
22 years in practice
Tufts University School of Medicine
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How often should one have the ca 125 test done?

Screening? No: Ca 125 is not a screening test. It can be elevated for reasons other than cancer. It should be used for follow up of certain cancers ie ovarian cancer. Even then, it is done periodically as part of surveillance strategy. Also used to help the clinician decide if a patient who is on chemotherapy is responding or not & some oncologists obtain them per 'cycle' of chemotherapy i.e. Every 3-4 wks.

Dr. Gurmukh Singh Dr. Singh
Pathology
45 years in practice
University of Pune, Armed Forces Medical College
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What do you suggest if my ca-125 test came back at 132. I'm scared?

Need for: Investigation. An elevated CA 125 does not necessarily mean cancer. All is suggests is that further investigation is needed. Consult this site for more info. Http://www. Nlm. Nih. Gov/medlineplus/ency/article/007217.htm

Dr. Lewis Hassell Dr. Hassell
Pathology
35 years in practice
University of Utah School of Medicine
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My ca-125 test came back at 132. I'm scared? What do these results mean?

CA-125: This marker is elevated significantly at this value. It's greatest specificity for ovarian cancer is in post-menopausal women, but a variety of things that irritate the lining of the abdomen and even chest, can elevate it mildly. So things like appendicitis, endometriosis, and even diverticulosis can also result in high levels. But, getting checked out for what is behind this is a good idea.

Dr. Helmy Guirgis Dr. Guirgis
Internal Medicine - Hematology & Oncology
42 years in practice
Creighton University School of Medicine
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I had the ca-125 test done and it came back with a level 25. Should I be concerned?

Yes and No: Ca-125 is a test for follow-up after diagnosis and with the treatment of ovarian cancer. It is elevated in many other diseases. The test should not be used for a fishing expedition because it would be misleading and concerning for a patient like you. Why was the test done in the first place? Do you have cancer? In any case a 25 level could be normal? What was the normal range. In the lab?

Dr. John Geisler Dr. Geisler
Gynecology - Oncology
23 years in practice
Indiana University School of Medicine
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Is 15 a normal ca-125 blood test?

Is 15 a normal ca-125 blood test?

CA 125: Yes, there are 2 main ca 125 scales depending on the manufacturer of the test. 1-20 and 1-35. However, ca 125 is not a good screening test just looking for cancer.

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Dr. Christian Schultheis Dr. Schultheis
Internal Medicine - Hematology & Oncology
20 years in practice
American University of the Caribbean
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What if your ca125 test is 125?

Not a lot: This test can be elevated for several reasons: heart failure, ovarian cancer, and multiple other causes. Without a diagnosis of ovarian cancer all it means is there are a lot of questions. This test should not be ordered without a diagnosis or a very high suspicion of ovarian cancer. Hope this helps.

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Dr. Gurmukh Singh Dr. Singh
Pathology
45 years in practice
University of Pune, Armed Forces Medical College
14

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I did the ca125 test. How accurately does it show cancer?

Not a diagnostic: Marker for cancer. Ca 125 is not a good test for making a diagnois of cancer. It is more useful for monitoring the course of a cancer associated with elevated ca 125 levels.

Dr. Joseph Woods Dr. Woods
Pathology
24 years in practice
State University of New York Upstate Medical University
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Could you please tell me if a ca125 blood test is high do I need tahbso?

Could you please tell me if a ca125 blood test is high do I need tahbso?

Not always.: If this test is high, it could mean endometrial cancer, fallopian tube cancer, lung cancer, breast cancer and gastrointestinal cancer. This can also indicate benign conditions, like endometriosis, other ovary disorders, and pregnancy, as well as any inflammatory condition in the abdiminal area. This is a big reason why it is used with other tests in evaluation and to follow treatment response.

Dr. Gurmukh Singh Dr. Singh
Pathology
45 years in practice
University of Pune, Armed Forces Medical College
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Can I eat before ca-125 lab test?

Yes: Many lab tests are done in a fasting state, however, ca-125 is not affected by eating. Due to variations from lab to lab, it is important to have the test in the same level for follow-up studies.

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Dr. Sewa Legha Dr. Legha
Internal Medicine - Oncology
46 years in practice
Punjab University, Christian Medical College
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Is fasting necessary before a ca 125 blood test?

Is fasting necessary before a ca 125 blood test?

No: I tis only important to fast when eating can alter a blood test result, which is the case when you check blood sugar and blood fats like cholesterol.

Dr. Myron Arlen Dr. Arlen
Surgery - Oncology
60 years in practice
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I recently found out that she had cysts in her ovaries, and had a ca125 test.?

No concern: Cysts of the ovary are common. If they are not complex but greater than 5cm, . Removal suggested under 5 cm can be watched. Ca 125 isa carbohydrate marker noted in tumors and inflammatory conditions. Since it is elevated in inflammatory pelvic disease it has no importance in benign disease. And can only be used for monitoring.

Dr. Myron Arlen Dr. Arlen
Surgery - Oncology
60 years in practice
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What to do if my friend recently found out that she had cysts in her ovaries, and had a ca125 test.?

Watch: Cysts in ovaries not uncommon and can be defined as simple or complex or even converting by a solid component. Ca125 means Carbohydrate antibody 125. Sugar markers like Ca125, Ca 19.9 Ca 17.1a have no diagnositic capabilities since they are elevated in inflammatory conditions. Ca monclonals can only be measured safely in known conditions of cancer to see progression or not.

Dr. David Fein Dr. Fein
Preventive Medicine
years in practice
University of Texas Southwestern Medical School at Dallas
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What is the ca-125 test for ovarian cancer?

What is the ca-125 test for ovarian cancer?

Measures a protein: The ca-125 test is a blood test that detects a protein in the blood that is produced by malignant ovarian cells. It is used to help determine if an ovarian cancer patient has had a relapse, or to help differentiate a cyst found by sonogram or ct. The most important point: it should never be used as a yearly screening test, and should not be requested by patients as a screening test.