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Doctor insights on: Can A Ca 125 Test Have A False Negative

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Dr. Julie Abbott
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


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Can a fibroid and a cyst come up on a ca 125 test?

Yes: Fibroids, benign cysts, endometriomas, and endometriosis can all result in a positive ca-125 test. Ca-125 is not a good screening test for ovarian cancer because there are so many causes of false positives. And furthermore, 50% of st 1 ovarian cancer may have a negative ca-125. Nonetheless, if you have a positive ca-125 and an ovarian cyst, it will probably need to be explored. ...Read more

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Can an ovarian cyst raise a ca-125 test?

Can an ovarian cyst raise a ca-125 test?

Ovarian cyst: An ovarian cyst can raise the ca 125, but depending on the age, an elevated ca 125 and an ovarian cyst/mass/tumor/growth (all interchangeable names) can be worrisome. ...Read more

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I had a ca 125 test done. Came back at 66 (no history of cancer). Ultrasound normal. Dr. Says no further evaluation needed. Is this true? I am 45

Agree: You should have never had that test done (ca-125) without a diagnosis of ovarian cancer. It is a nonspecific test. But i agree, no further testing necessary. Routine follow up with your pcp and gynecologist. Hope this helps. ...Read more

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I had a ca 125 test done(no previous history of cancer)that came back as a 66. Ultrasound came back normal. Dr. Said no further evaluation is needed. True?

I had a ca 125 test done(no previous history of cancer)that came back as a 66. Ultrasound came back normal. Dr. Said no further evaluation is needed. True?

A CA 125: Test should never be ordered out of the blue, especially in a young woman with no cancer history. It increases the cost of health care, leads to unnecessary testing and worry. Despite good intent, this is bad practice. ...Read more

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Certain food affect ca125 tests?

Not likely: Ca 125 test looks for a particular glycoprotein in blood and diet is not likely to affect the results. ...Read more

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What is the ca-125 test?

What is the ca-125 test?

CA-125: Cancer antigen 125 (ca-125) is a protein found on the surface of many ovarian cancer cells. It also can be found in other cancers and in small amounts in normal tissue. A ca-125 test measures the amount of this protein in the blood and can be used as a tumor marker. ...Read more

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How often should one have the ca 125 test done?

Screening? No: Ca 125 is not a screening test. It can be elevated for reasons other than cancer. It should be used for follow up of certain cancers ie ovarian cancer. Even then, it is done periodically as part of surveillance strategy. Also used to help the clinician decide if a patient who is on chemotherapy is responding or not & some oncologists obtain them per 'cycle' of chemotherapy i.e. Every 3-4 wks. ...Read more

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What do you suggest if my ca-125 test came back at 132. I'm scared?

Need for: investigation. An elevated CA 125 does not necessarily mean cancer. All is suggests is that further investigation is needed. Consult this site for more info. http://www.nlm.nih.gov/medlineplus/ency/article/007217.htm ...Read more

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My ca-125 test came back at 132. I'm scared? What do these results mean?

CA-125: This marker is elevated significantly at this value. It's greatest specificity for ovarian cancer is in post-menopausal women, but a variety of things that irritate the lining of the abdomen and even chest, can elevate it mildly. So things like appendicitis, endometriosis, and even diverticulosis can also result in high levels. But, getting checked out for what is behind this is a good idea. ...Read more