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Doctor insights on: Ca125 Ovarian Cancer

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How accurate is ca125 test for ovarian cancer?

How accurate is ca125 test for ovarian cancer?

99% when cancer: Ca-125 is 99% accurate if an ovarian cyst or tumor happens to be cancer. The problem with this blood test is that it is very inaccurate when there is no cancer (called a false positive), sometimes up to 45%. This is why ob/gyns do not use this test as a screening test, or at patient request. ...Read more

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Dr. Barry Rosen
4,214 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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How reliable is the ca125 test for ovarian cancer?

How reliable is the ca125 test for ovarian cancer?

CA 125: Ca 125 is not a reliable test to look for ovarian cancer. It is used in follow up of a woman with ovarian cancer or similar cancers. ...Read more

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Can a woman have a normal ca125 blood test and still have ovarian cancer?

Can a woman have a normal ca125 blood test and still have ovarian cancer?

Ovarian cancer: Yes. Only 85% of ovarian cancers have an elevated ca 12 at presentation. Therefore, 15 of every 100 women with a diagnosis of ovarian cancer have a ca 125 within the normal range. Ca 125 is not a diagnostic test. But is used to follow the progress of chemotherapy. ...Read more

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Does a ca125 blood test check for cancers other than ovarian cancer?

Yes: There are other cancers that will have a positive ca-125. They include cancer of the pancreas, stomach, esophagus, liver, breast, colon, or lung. Cancer of the lining of the abdominal cavity, and cancer of the fallopian tubes or lining of uterus. ...Read more

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My ca125 levels are slightly elevated and there is a solid mass on my ovary, should I be concerened that it is ovarian cancer?

Depends: Ask your gyn. A solid mass is concerning, but your age, menopausal status, and the ultrasound characteristics are important as well. Elevated ca-125 suggests ovarian cancer, but may be somewhat elevated in many benign conditions, as well, including endometriosis. All of this needs a discussion with your gyn and a possible referral to a gyn oncologist - who are the real experts in this area. ...Read more

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Wife complete debulking for stge 4 ovarian cancer. No l-nodes involved. All cancer removed. Ca125 44 at diagnosis. Ca125 is 3 after 6 rds of chemo. What questions should I ask onc re: prognosis?

High Risk: It sounds like she has had a good respons but she is high risk. You need to continue to have her monitored no matter what the numbers show. Her risk of recurrence is high just based on the staging. Her oncologist is the expert in this field. Support gourps may help as well. Good luck. ...Read more

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Mom has stg 4 ovarian cancer with recurrence. Is now on avastin (bevacizumab). She feels good, ascetis has gone down, however ca125 has gone from 211 to 3000. Why?

Mom has stg 4 ovarian cancer with recurrence. Is now on avastin (bevacizumab). She feels good, ascetis has gone down, however ca125 has gone from 211 to 3000. Why?

Good question: Why? It is definitely something her oncologist should be concerned about and should try to answer the question. Your mom should get some evaluation done-i.e. Some imaging studies- like ct and or pet scan to answer the question and to see whether Avastin (bevacizumab) alone perhaps is not enough. ...Read more

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I am worried I have ovarian cancer. I have had some pelvic pain for three months. I've had ultrasound , ca125 and MRI scan. All show nothing. ?

Ovarian cancer: Although there is no screening test for ovarian cancer, you have had tests that would help show it if it is present. There are many more common causes of pain (endometriosis, adhesions, interstitial cystitis ...) which are much more likely. ...Read more

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Finished chemo for stage iiia ovarian cancer in oct 2013. Ca125 was 8 6wks ago and 20 now have large right groin node. Is the ca125 jump a lot? Can incisional hernia cause lymph node to swell?

Seek medical exam: Your oncologist needs to know about this groin node if you have not yet told him.Since your ca 125 is still in the normal range, i would not draw any conclusions but your doctor needs to examine you and guide you. It is best not to follow your disease with ca125 right now as it will likely have such fluctuatiosns, causing you to be nervous and anxious, yet it does not help in making treatment decis. ...Read more

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Dr. Gurmukh Singh
480 doctors shared insights

Ovarian Cancer (Definition)

It is a cancer which arises from the ovary. This cancer is typically silent, producing little or no symptoms till it spreads, first into the pelvic area and later into the peritoneal cavity leading to fluid accumulation(ascites) which is often the first symptom. Despite its late presentation, there is a reasonable treatment for it, with some long term survivors even ...Read more


Dr. Julie Abbott
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more