Doctor insights on:
Ca 125 Stress Influence
Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?
Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normalSee 1 more doctor answer
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Unrealted: Ca125 is a carbohydrate tumor marker seen in many cases of ovarian Cancer. It is not specific to cancer and can be elevated in ovarian inflammation and alcohol cirrhosis. Its value is in monitoring ovarian Ca so that rising levels on chemo mean failure while decreasing levels during chemo means response. It should not be used for diagnosis.
Not a lot: This test can be elevated for several reasons: heart failure, ovarian cancer, and multiple other causes. Without a diagnosis of ovarian cancer all it means is there are a lot of questions. This test should not be ordered without a diagnosis or a very high suspicion of ovarian cancer. Hope this helps.See 1 more doctor answer
Many causes: It is commonly elevated in ovarian cancer. But it can go up from any reason which causes irritation of the peritoneal lining of your abdomen which includes some benign conditions too. It depends on the level and also if it is going up steadily or staying elevated but stable and not increasing. Your gynecologist can help you to sort it out.
Ovarian Cancer: It is a tumor marker for ovarian, endometrium, fallopian tube, lung, breast and gastrointestinal tract cancers. It is commonly used to follow ovarian cancer in response to therapeutic treatments and can be positive in nearly 80% of cases. It is not specific to cancer, however, and can be elevated in benign abdominal problems too such as endometriosis.See 1 more doctor answer
Unknown: At this point in time there is a lot of discussion about this topic and many who feel there may be some association but there has been no known proof of an association of Lyme disease and an elevated CA 125. This is still being researched and nothing that can say a definite cause and affect. Hope this helps.
Not sure: Ca 125 is used to follow response of ovarian cancer to treatment, it is not considered a good screening test for the general population (too many false positives) but is used to screen patients that cary a deleterious brca mutation. Urine ca125 is not routinely done but very elevated levels may be significant; but it doesn't correnlate with serum (http://www. Ncbi. Nlm. Nih. Gov/pubmed/7944239#).See 1 more doctor answer
Not a diagnostic: Marker for cancer. Ca 125 is not a good test for making a diagnois of cancer. It is more useful for monitoring the course of a cancer associated with elevated ca 125 levels.
Not always.: If this test is high, it could mean endometrial cancer, fallopian tube cancer, lung cancer, breast cancer and gastrointestinal cancer. This can also indicate benign conditions, like endometriosis, other ovary disorders, and pregnancy, as well as any inflammatory condition in the abdiminal area. This is a big reason why it is used with other tests in evaluation and to follow treatment response.
No diagnosis: If there is a cyst of the ovary smaller than 5 cm it can be watched. If complex on sono or larger than 5 cm. biopsy indicated. Ca 125 cant be used for diagnosis. FDA has approved the Carbohydrate Antigen measurements for monitoring purposes only. Ca125 will go up in the presence of an inflammatory process and can also go to levels over 1000 associated with ascites from alcoholic cirrhosis.
Is it ovarian cyst?: The best thing to do is consult with your gynecologist /oncologist. Good luck.
Cyst needs study: Fluid filled ovarian mass is a cytst either simple or complex. Simple cysts larger than 5cm need excision. Complex cysts probably should be removed. Ca 125 has little value unless lesion is malignant, has been removed and Ca 125 used for monitoring response. To treatment.
CA-125: This marker is quite non-specific for cancer, particularly in pre-menopausal women. Any things that irritate the lining of the abdomen (such as cysts, endometriosis, and non-ovarian things as well) can prompt elevations in the range you have noted. Other means of screening for cancer however are also imperfect. If you are at high risk, other follow-up may be needed.
In the peritoneal li: It arises from the irritation or growth of peritoneal lining cells. These cells also cover the ovaries. So ca 125 is often used as a test to screening for ovarian cancer. But it often raised in any conditions causing intra -abdominal irritation like in peritonitis.
Part of cell surface: Ca125 is a component of mucin, mucous like material on the surface of cells that provides lubrication and is a barrier to foreign invaders. It is found on many different types of cells, including the female organs. It is shed from tumor cells in ovarian cancer, and therefore can be measured in blood as a tumor marker, but since ca125 is on many other kinds of cells, it is not specific.
CA125 Definition: Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast et al. In 1983.
None to minimal: If the ca-125 was going to be used simply as another blood test for example in a yearly physical, you should not be terribly concerned at all. My answer is different however, if you have a history of a disease such as ovarian cancer and that it should be checked. I also might order it if you have a strong family history of ovarian cancer for example. If not you should not be concerned.
Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more