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Doctor insights on: Ca 125 Over 1400

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Dr. Bernard Seif
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


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What if your ca125 test is 125?

What if your ca125 test is 125?

Not a lot: This test can be elevated for several reasons: heart failure, ovarian cancer, and multiple other causes. Without a diagnosis of ovarian cancer all it means is there are a lot of questions. This test should not be ordered without a diagnosis or a very high suspicion of ovarian cancer. Hope this helps. ...Read more

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What is the ca-125 test?

CA-125: Cancer antigen 125 (ca-125) is a protein found on the surface of many ovarian cancer cells. It also can be found in other cancers and in small amounts in normal tissue. A ca-125 test measures the amount of this protein in the blood and can be used as a tumor marker. ...Read more

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What causes my ca 125 to go up?

Many causes: It is commonly elevated in ovarian cancer. But it can go up from any reason which causes irritation of the peritoneal lining of your abdomen which includes some benign conditions too. It depends on the level and also if it is going up steadily or staying elevated but stable and not increasing. Your gynecologist can help you to sort it out. ...Read more

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What does ca 125 level 600 mean?

High: It's quite elevated, why was it done? Your doc needs to discuss this results with you in the context in which it was ordered. ...Read more

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What is the significance of ca-125?

Ovarian Cancer: It is a tumor marker for ovarian, endometrium, fallopian tube, lung, breast and gastrointestinal tract cancers. It is commonly used to follow ovarian cancer in response to therapeutic treatments and can be positive in nearly 80% of cases. It is not specific to cancer, however, and can be elevated in benign abdominal problems too such as endometriosis. ...Read more

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Ca125 level is a marker for which tumor?

Ovarian: It is neither sensitive nor specific for screening. However, its recurrence after removal of a tumor that produces it suggests recurrence. ...Read more

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Is 80.04 result of my ca 125 can be cured?

Cannot tell: More information is needed to recommend possibility of cure. Please re-ask the question with what diagnosis included and any previous treatment. ...Read more

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How often should one have the ca 125 test done?

Screening? No: Ca 125 is not a screening test. It can be elevated for reasons other than cancer. It should be used for follow up of certain cancers ie ovarian cancer. Even then, it is done periodically as part of surveillance strategy. Also used to help the clinician decide if a patient who is on chemotherapy is responding or not & some oncologists obtain them per 'cycle' of chemotherapy i.e. Every 3-4 wks. ...Read more

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I'm concerned about high ca 125? What should I do?

Incomplete info: Why did you have the test done? All lab results need to be interpreted in the clinical context and the doctor who ordered the test is usually in the best position to do that. Ca 125 is not a good test to diagnose a primary illness. ...Read more

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Ca 125 was 0 50 4 months before and now it is 5 6 is it a danger ?

Need more info: A rising ca125 in a patient with a prior history of ovarian cancer is concerning and work up with ct scans etc is required. In patients with no cancer history this is not a useful test. ...Read more

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What do you suggest if my ca-125 test came back at 132. I'm scared?

Need for: investigation. An elevated CA 125 does not necessarily mean cancer. All is suggests is that further investigation is needed. Consult this site for more info. http://www.nlm.nih.gov/medlineplus/ency/article/007217.htm ...Read more

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Is a ca 125 level of 18 normal for a 38 year old female? Range is <36.

Yes: Ca 125 is not a good screening test. See this site for more info. http://www.medicinenet.com/ca_125/article.htm. ...Read more

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My ca-125 test came back at 132. I'm scared? What do these results mean?

CA-125: This marker is elevated significantly at this value. It's greatest specificity for ovarian cancer is in post-menopausal women, but a variety of things that irritate the lining of the abdomen and even chest, can elevate it mildly. So things like appendicitis, endometriosis, and even diverticulosis can also result in high levels. But, getting checked out for what is behind this is a good idea. ...Read more

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I had the ca-125 test done and it came back with a level 25. Should i be concerned?

Yes and No: Ca-125 is a test for follow-up after diagnosis and with the treatment of ovarian cancer. It is elevated in many other diseases.The test should not be used for a fishing expedition because it would be misleading and concerning for a patient like you. Why was the test done in the first place? Do you have cancer? In any case a 25 level could be normal? What was the normal range.In the lab? ...Read more

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Should ca-125 be within normal range (<35) for a healthy person or should it be zero?

Should ca-125 be within normal range (<35) for a healthy person or should it be zero?

Ca 125: The "normal" ca125 was established for post-menopausal women at <35 (any value 0-35). Most premenopausal women will also have values in this range but not always since there are many benign reasons it can fluctuate. Some "healthy" women of all ages will have a level above 35! this is one of the reasons it is not effective as a screening test. ...Read more

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Ca-125 was elevated at 40? Once told by gyno that I have precancerous cells. Should this combination worry me?

Yes!: Ca125 is a cancer marker. If elevated is something to worry , even though its not specific. If you were told to have a precancerous lesion , wherever it was, needs to be reevaluated. ...Read more

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Ca125 result is 20 which is within normal range >35. What is the perfect range. Is a result of 20 indicative of endometriosis at all?

It does not help: CA 125 is a useless test unless it is elivated above 35. Furthermore it does not pin point to an exact diagnosis as it can be raised in many different abdominal conditions including Infections, cancer and endometriosis. You will have to rely on your doctor's assessment of your symptoms and physical/pelvic examination and judgement. ...Read more

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Her last CA 125 obtained yesterday is 1066 I wanna know what will be the next step for her management especially last ca125 was around 250 ?

Needs further testin: A rising CA125 requires further investigation to rule out a Gynecologic cancer especially Ovarian Cancer. The best test to start with is a recheck of CA125 (unless done in the last 2-3 weeks). An Ultrasound of the abdomen and Pelvis can assess the Ovarian areas for any tumor/cyst on the Ovaries. A CT scan of the abdomen/Pelvis is another alternative if the CA 125 reading is going up higher. ...Read more