Doctor insights on:
Ca 125 Over 1400
Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?
Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read moreSee 1 more doctor answer
Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more
Not a lot: This test can be elevated for several reasons: heart failure, ovarian cancer, and multiple other causes. Without a diagnosis of ovarian cancer all it means is there are a lot of questions. This test should not be ordered without a diagnosis or a very high suspicion of ovarian cancer. Hope this helps. ...Read moreSee 1 more doctor answer
CA-125: Cancer antigen 125 (ca-125) is a protein found on the surface of many ovarian cancer cells. It also can be found in other cancers and in small amounts in normal tissue. A ca-125 test measures the amount of this protein in the blood and can be used as a tumor marker. ...Read moreSee 1 more doctor answer
Many causes: It is commonly elevated in ovarian cancer. But it can go up from any reason which causes irritation of the peritoneal lining of your abdomen which includes some benign conditions too. It depends on the level and also if it is going up steadily or staying elevated but stable and not increasing. Your gynecologist can help you to sort it out. ...Read more
Ovarian Cancer: It is a tumor marker for ovarian, endometrium, fallopian tube, lung, breast and gastrointestinal tract cancers. It is commonly used to follow ovarian cancer in response to therapeutic treatments and can be positive in nearly 80% of cases. It is not specific to cancer, however, and can be elevated in benign abdominal problems too such as endometriosis. ...Read moreSee 1 more doctor answer
Screening? No: Ca 125 is not a screening test. It can be elevated for reasons other than cancer. It should be used for follow up of certain cancers ie ovarian cancer. Even then, it is done periodically as part of surveillance strategy. Also used to help the clinician decide if a patient who is on chemotherapy is responding or not & some oncologists obtain them per 'cycle' of chemotherapy i.e. Every 3-4 wks. ...Read more
Incomplete info: Why did you have the test done? All lab results need to be interpreted in the clinical context and the doctor who ordered the test is usually in the best position to do that. Ca 125 is not a good test to diagnose a primary illness. ...Read more
Yes: Ca 125 is not a good screening test. See this site for more info. http://www.medicinenet.com/ca_125/article.htm. ...Read more
CA-125: This marker is elevated significantly at this value. It's greatest specificity for ovarian cancer is in post-menopausal women, but a variety of things that irritate the lining of the abdomen and even chest, can elevate it mildly. So things like appendicitis, endometriosis, and even diverticulosis can also result in high levels. But, getting checked out for what is behind this is a good idea. ...Read more
Yes and No: Ca-125 is a test for follow-up after diagnosis and with the treatment of ovarian cancer. It is elevated in many other diseases.The test should not be used for a fishing expedition because it would be misleading and concerning for a patient like you. Why was the test done in the first place? Do you have cancer? In any case a 25 level could be normal? What was the normal range.In the lab? ...Read more
Ca 125: The "normal" ca125 was established for post-menopausal women at <35 (any value 0-35). Most premenopausal women will also have values in this range but not always since there are many benign reasons it can fluctuate. Some "healthy" women of all ages will have a level above 35! this is one of the reasons it is not effective as a screening test. ...Read moreSee 1 more doctor answer
Ca-125 was elevated at 40? Once told by gyno that I have precancerous cells. Should this combination worry me?
Ca125 result is 20 which is within normal range >35. What is the perfect range. Is a result of 20 indicative of endometriosis at all?
It does not help: CA 125 is a useless test unless it is elivated above 35. Furthermore it does not pin point to an exact diagnosis as it can be raised in many different abdominal conditions including Infections, cancer and endometriosis. You will have to rely on your doctor's assessment of your symptoms and physical/pelvic examination and judgement. ...Read more
Her last CA 125 obtained yesterday is 1066 I wanna know what will be the next step for her management especially last ca125 was around 250 ?
Needs further testin: A rising CA125 requires further investigation to rule out a Gynecologic cancer especially Ovarian Cancer. The best test to start with is a recheck of CA125 (unless done in the last 2-3 weeks). An Ultrasound of the abdomen and Pelvis can assess the Ovarian areas for any tumor/cyst on the Ovaries. A CT scan of the abdomen/Pelvis is another alternative if the CA 125 reading is going up higher. ...Read more