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Doctor insights on: Ca 125 Normal Level

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Dr. Steven Griggs
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


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Is a ca 125 level of 18 normal for a 38 year old female? Range is <36.

Yes: Ca 125 is not a good screening test. See this site for more info. http://www.medicinenet.com/ca_125/article.htm. ...Read more

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2 ovarian cyst, one 8 CM and the other 6cm. Had vus done, low level echos. Going back in 2 months for review. Ca-125 in normal limits. Concered?

2 ovarian cyst, one 8 CM and the other 6cm. Had vus done, low level echos. Going back in 2 months for review. Ca-125 in normal limits.  Concered?

Low degree of concer: Most common cause of such benign cysts are functional cysts that are very common in reproductive age females. Unless, presenting with symptoms (pain, nausea, vomiting, fever etc), your physician may opt to follow them with a repeat us in 3-6 months. Unless you have strong family hx of cancer, or personal hx of cancer, there is a low level of suspicion for ovarian cancer. ...Read more

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How concerned should I be if my ca125 level was not ordered this year?

How concerned should I be if my ca125 level was not ordered this year?

None to minimal: If the ca-125 was going to be used simply as another blood test for example in a yearly physical, you should not be terribly concerned at all. My answer is different however, if you have a history of a disease such as ovarian cancer and that it should be checked. I also might order it if you have a strong family history of ovarian cancer for example. If not you should not be concerned. ...Read more

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What does ca 125 level 600 mean?

High: It's quite elevated, why was it done? Your doc needs to discuss this results with you in the context in which it was ordered. ...Read more

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Ca125 level is a marker for which tumor?

Ca125 level is a marker for which tumor?

Ovarian: It is neither sensitive nor specific for screening. However, its recurrence after removal of a tumor that produces it suggests recurrence. ...Read more

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I had the ca-125 test done and it came back with a level 25. Should i be concerned?

Yes and No: Ca-125 is a test for follow-up after diagnosis and with the treatment of ovarian cancer. It is elevated in many other diseases.The test should not be used for a fishing expedition because it would be misleading and concerning for a patient like you. Why was the test done in the first place? Do you have cancer? In any case a 25 level could be normal? What was the normal range.In the lab? ...Read more

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Should ca-125 be within normal range (<35) for a healthy person or should it be zero?

Should ca-125 be within normal range (<35) for a healthy person or should it be zero?

Ca 125: The "normal" ca125 was established for post-menopausal women at <35 (any value 0-35). Most premenopausal women will also have values in this range but not always since there are many benign reasons it can fluctuate. Some "healthy" women of all ages will have a level above 35! this is one of the reasons it is not effective as a screening test. ...Read more

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