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Doctor insights on: Ca 125 Levels Meaning

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Dr. Thomas Fiala
114 doctors shared insights

Ca125 (Definition)

Ca125 is also known as Cancer antigen 125. Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


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Is a ca 125 level of 18 normal for a 38 year old female? Range is <36.

Yes: Ca 125 is not a good screening test. See this site for more info. http://www.medicinenet.com/ca_125/article.htm. ...Read more

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What does ca 125 level 600 mean?

High: It's quite elevated, why was it done? Your doc needs to discuss this results with you in the context in which it was ordered. ...Read more

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I had the ca-125 test done and it came back with a level 25. Should i be concerned?

Yes and No: Ca-125 is a test for follow-up after diagnosis and with the treatment of ovarian cancer. It is elevated in many other diseases.The test should not be used for a fishing expedition because it would be misleading and concerning for a patient like you. Why was the test done in the first place? Do you have cancer? In any case a 25 level could be normal? What was the normal range.In the lab? ...Read more

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Does an elevated ca 125 level always indicate that ovarian cancer is present?

Does an elevated ca 125 level always indicate that ovarian cancer is present?

No: Ca-125 may also be elevated in other cancers (i.e. Endometrial, fallopian tube, lung, breast and gastrointestinal cancers.) it can also be elevated with endometriosis or any inflammatory condition in the abdominal area. ...Read more

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2 ovarian cyst, one 8 CM and the other 6cm. Had vus done, low level echos. Going back in 2 months for review. Ca-125 in normal limits. Concered?

2 ovarian cyst, one 8 CM and the other 6cm. Had vus done, low level echos. Going back in 2 months for review. Ca-125 in normal limits.  Concered?

Low degree of concer: Most common cause of such benign cysts are functional cysts that are very common in reproductive age females. Unless, presenting with symptoms (pain, nausea, vomiting, fever etc), your physician may opt to follow them with a repeat us in 3-6 months. Unless you have strong family hx of cancer, or personal hx of cancer, there is a low level of suspicion for ovarian cancer. ...Read more

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CA 125 level in a 70yr woman who had hysterectomy with removal of ovaries+Fallopian tubes=341U/ml. Possibillity?Waiting for results of pelvic+abd u/s.

CA 125 level in a 70yr woman who had hysterectomy with removal of ovaries+Fallopian tubes=341U/ml. Possibillity?Waiting for results of pelvic+abd u/s.

Waiting is hard: Although it's hard to wait, your doctor is evaluating you for possible abdominal or pelvic cancers which can show up even after removal of the uterus, tubes, and ovaries. They may also recommend a CT (cat scan) or PET scan If the u/s isnt helpful. Best wishes for good results! ...Read more

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