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Doctor insights on: Ca 125 Elevated Endometriosis

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Dr. Ira Katz
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


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Ca125 result is 20 which is within normal range >35. What is the perfect range. Is a result of 20 indicative of endometriosis at all?

It does not help: CA 125 is a useless test unless it is elivated above 35. Furthermore it does not pin point to an exact diagnosis as it can be raised in many different abdominal conditions including Infections, cancer and endometriosis. You will have to rely on your doctor's assessment of your symptoms and physical/pelvic examination and judgement. ...Read more

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CA 125=54 and endometriosis ..any relation? Anything to worry as I am very stressed out

Unrealted: Ca125 is a carbohydrate tumor marker seen in many cases of ovarian Cancer. It is not specific to cancer and can be elevated in ovarian inflammation and alcohol cirrhosis. its value is in monitoring ovarian Ca so that rising levels on chemo mean failure while decreasing levels during chemo means response. It should not be used for diagnosis. ...Read more

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I have an endometriosis cyst on both or sometimes only on one side of my ovaries, do I need to go for a check up for my ca-125 every single year?

Complicated: Ca-125 can be useful to follow endometriosis, especially to see how one therapy versus another is working. There is no strict rule as to how often to check it. Generally that is individualized for each patient. ...Read more

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I had a CA-125 done for ovarian cysts (10.5cm and 4cm) Test came back 190. Had another test weeks later and new u/s. Cyst is now 8.4 and CA-125 is 110. Is this even possible? Cysts are hypoechoic cystic lesions possibly endometriomas & endometriosis.

CA-125 testing: CA- 125 testing is notoriously inaccurate when it comes to testing for ovarian cancer especially when endometriosis is a part of the equation. IF there is continued concern most MD's will take a "look/see" with the laparoscope and confirm a definitive diagnosis. ...Read more

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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I have an hemmorghagic cyst on my left ovary. I had the ca125 test done. It was 55 does this mean I have cancer? I do have endometriosis

I have an hemmorghagic cyst on my left ovary. I had the ca125 test done. It was 55 does this mean I have cancer? I do have endometriosis

No: It is just a test, it is not a diagnostic one- just a test. You should be re-tested- if you are worried the ovary can always come out and be looked at under a microscope. ...Read more

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Dr. Michael Traub
1,198 doctors shared insights

Endometriosis (Definition)

An abnormal condition where some endometrial tissue, which is lining tissue of the uterus, is located outside the uterus. The displaced tissue, just like the tissue lining the uterus, bleeds during each menstrual cycle. Endometriosis can be very painful, and can result ...Read more