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Doctor insights on: Ca 125 Blood Test Ovarian Cancer

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Why is the ca-125 blood test for ovarian cancer not part of a yearly checkup?

Why is the ca-125 blood test for ovarian cancer not part of a yearly checkup?

Not beneficial: The ca125 test is not used for screening for ovarian cancer because it does not work in the general female population. The ca125 can be abnormal in situations without any cancer and most importantly using this test does not save any lives like in the case of maamograms for breast cancer. ...Read more

Dr. Barry Rosen
4,298 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Why is the ca-125 blood test to check for ovarian cancer not part of a woman's checkup?

Why is the ca-125 blood test to check for ovarian cancer not part of a woman's checkup?

Not useful: It is neither sensitive nor specific for ovarian cancer and is not useful as a screening test. If elevated at diagnosis of ovarian cancer, it is useful in following the progress of tumor and response to treatment. ...Read more

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Is it possible to have ovarian cancer and have a normal ca 125 blood test?

Is it possible to have ovarian cancer and have a normal ca 125 blood test?

Yes.: Ca125 can vary from person to person and can change under various circumstances not related to cancer. It is more useful as a way to track disease progression or treatment success. ...Read more

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Does a ca125 blood test check for cancers other than ovarian cancer?

Yes: There are other cancers that will have a positive ca-125. They include cancer of the pancreas, stomach, esophagus, liver, breast, colon, or lung. Cancer of the lining of the abdominal cavity, and cancer of the fallopian tubes or lining of uterus. ...Read more

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Can a woman have a normal ca125 blood test and still have ovarian cancer?

Can a woman have a normal ca125 blood test and still have ovarian cancer?

Ovarian cancer: Yes. Only 85% of ovarian cancers have an elevated ca 12 at presentation. Therefore, 15 of every 100 women with a diagnosis of ovarian cancer have a ca 125 within the normal range. Ca 125 is not a diagnostic test. But is used to follow the progress of chemotherapy. ...Read more

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I have a 2.8cm ovarian cyst. I have the brca1 mutated gene. My ca125 blood test came back normal. Could it still be early stage of ovarian cancer?

Rare: Ovarian cysts are of concern when over 5 cm. If the small cyst is not complex it is usually followed by ultrasound. Ca 125 has no diagnostic implication but is only of value for monitoring. Brca1 suggests the cyts should be followed. ...Read more

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Any reliable blood test for ovarian cancer?

Any reliable blood test for ovarian cancer?

NO: There is no good / reliable blood test for ovarian cancer as a screening test. However, if you have ovarian cancer , a cancer marker- ca-125, in majority times is elevated in ovarian cancer and this can be used to monitor response to treatment. ...Read more

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Any good easy blood test to screen for ovarian cancer yet?

Any good easy blood test to screen for ovarian cancer yet?

No: Some may offer a ca-125 blood test as a screening for ovarian cancer. Unfortunately, while ca-125 is found in 80-90% of ovarian cancer patients, it is not very specific (meaning it is elevated in a number of conditions) and is not found in early cancers. It is better used as a method of following cancer treatment and progression, once it is diagnosed. ...Read more

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What the test for ovarian cancer? Ultrasound or blood test

What the test for ovarian cancer? Ultrasound or blood test

Several tests done.: Pain and bloating can be signs of ovarian cancer, but they can be just from a painful period. Ovarian cancer would be more likely in older women, like 40+ years, and most likely in women 70+ years. Other tests, like pelvic exam, ca-125, and transvaginal ultrasound would be needed. The ultimate way to know is surgery to see if it is in fact, a tumor of something else. ...Read more

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Can they detect ovarian cancer through a blood test?

Can they detect ovarian cancer through a blood test?

Backward: There is no screening test for ovca. However, if you have ovarian cancer, a ca-125 level may or may not be elevated. If it is, it may be one thing monitired for response. Getting ca-125, an expensive blood test of unproven value before knowing you have the cancer is inded backward, costly, non-specific and can led to unnecessary worry. ...Read more

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What do doctors look for in an ovarian cancer blood test?

CA-125,OVA1BRCA1&2: The test are not for screening patients but for risk indicators ca-125 ova1 brca1 brca2 ova1s used for early prediction of ovarian cancer.It is helpful in predicting if ovarian tumor is malignant before starting any treatment. ...Read more

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I have all the symptoms of ovarian cancer. Had a blood test and it was negative and my scan turned out negative too. So what is the matter?

I have all the symptoms of ovarian cancer. Had a blood test  and it was negative and my scan turned out negative too.  So what is the matter?

Ovarian cancer: More often than not, ovarian cancer does not have symptoms. If your scan and blood tests are negative, obviously one must consider other causes. If you separately list your symptoms here, we might be able to help. Even better might be a consult via HealthTap Prime or Healthtap Concierge. Whatever we can do to help. Good luck. ...Read more

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I may have an abnormal he 4 blood test. Do I have ovarian cancer. I have an ovarian cyst 3.4 CM which is being monitored with transvaginal ultrasounds?

I may have an abnormal he 4 blood test. Do I have ovarian cancer. I have an ovarian cyst 3.4 CM which is being monitored with transvaginal ultrasounds?

An abnormal HE-4: Is not good but what is the ca-125 or did they do an ova-1? And if you are not , you should be referred to a gyn oncologist for evaluation and is not hard to remove that ovary through the davinci or laparoscope if necessary, as at your age the ovary is worthless and hopefully it will be benign. ...Read more

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How accurate is ca125 test for ovarian cancer?

How accurate is ca125 test for ovarian cancer?

99% when cancer: Ca-125 is 99% accurate if an ovarian cyst or tumor happens to be cancer. The problem with this blood test is that it is very inaccurate when there is no cancer (called a false positive), sometimes up to 45%. This is why ob/gyns do not use this test as a screening test, or at patient request. ...Read more

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How reliable is the ca125 test for ovarian cancer?

How reliable is the ca125 test for ovarian cancer?

CA 125: Ca 125 is not a reliable test to look for ovarian cancer. It is used in follow up of a woman with ovarian cancer or similar cancers. ...Read more

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What is the ca-125 test for ovarian cancer?

What is the ca-125 test for ovarian cancer?

Measures a protein: The ca-125 test is a blood test that detects a protein in the blood that is produced by malignant ovarian cells. It is used to help determine if an ovarian cancer patient has had a relapse, or to help differentiate a cyst found by sonogram or ct. The most important point: it should never be used as a yearly screening test, and should not be requested by patients as a screening test. ...Read more

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How precise is the ca-125 test for ovarian cancer?

Other conditions too: Ca25 test can be positive in many conditions pregnancy endometriosis uterine fibroids pancreatitis liver disease normal menstruation other malignancies like lung, breast.Pacreas and GI tract cysts of the ovaries so here you have it it is not a specific test for ovarian cancer, thogh it may be positive as well. ...Read more

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How accurate is the ca-125 test for an ovarian cancer?

Not very.: Ca 125 is touted as a screening tool for ov ca but is elevated in only 50% of those with early stage disease. Approx 1% of normals have a high ca 125. Since ovarian cancer is relatively uncommon, the ability of a positive test to predict ca is about 3%. There is general consensus that ca 125 is not a good screening tool for average risk females. Consider ca 125 for those with high risk. ...Read more

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Does ca-125 test for ovarian cancer always tell you if you are cancer-free ?

Probably not.: Ca-125 is useful for diagnosis and follow up of the disease, but it by itself is not effective to screen for early-stage ovarian cancer due to its low sensitivity and specificity. Therefore, it should not be the only test to tell if cancer free. Other tsts, like transvaginal ultrasound, may be needed. ...Read more

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My ca125 levels are slightly elevated and there is a solid mass on my ovary, should I be concerened that it is ovarian cancer?

Depends: Ask your gyn. A solid mass is concerning, but your age, menopausal status, and the ultrasound characteristics are important as well. Elevated ca-125 suggests ovarian cancer, but may be somewhat elevated in many benign conditions, as well, including endometriosis. All of this needs a discussion with your gyn and a possible referral to a gyn oncologist - who are the real experts in this area. ...Read more

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Dr. Daniel Lebowitz
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


Dr. Gurmukh Singh
496 doctors shared insights

Ovarian Cancer (Definition)

A typically silend cancer which ...Read more