Top
20
Doctor insights on: C4 Complement High

Share
1

1
2yr old had blood work done in Dec & in Feb results are saying she had a high C3, C4 Complement & high C-Reactive protein & ES rate what's wrong?

2yr old had blood work done in Dec & in Feb results are saying she had a high C3, C4 Complement & high C-Reactive protein & ES rate what's wrong?

Abnormal labs: These lab results could mean different things depending on her symptoms I would suggest a follow up visit with the ordering doctor to discuss these results. Read more

Complement (Definition)

The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more


2

2
What could high immunoglobulin IG m and complement C4 mean?

What could high immunoglobulin IG m and complement C4 mean?

May be significant: Immunogloblin m (igm) is one of the 5 classes of proteins that have antibodies. C4 is part of the complement cascade, a series of proteins that are important in immunity and inflammation. Elevation of both may occur in various diseases. The significance of the specific values for you depends on what your clinical problem is. Therefore, I can not be more specific as to what it means for you. Read more

3

3
What does it mean when you have high levels of complement c4 and sedimentation rate westergren?

What does it mean when you have high levels of complement c4 and sedimentation rate westergren?

Complement C4/ESR: Complement C4 and the erythrocyte sedimentation rate are usually high in conditions which cause acute or chronic inflammation. These are often measured in autoimmune diseases and rheumatoid arthritis, but they can be elevated in many other conditions, including cancer and heart attacks. The results need to be interpreted by your physician. Good luck. Read more

4

4
What means very high CH50 complement? Mine is 277 CAE, C3 and C4 normal. Ref ranges for lab are only greater than 60, but I read high could be pathologis

What means very high CH50 complement? Mine is 277 CAE, C3 and C4 normal. Ref ranges for lab are only greater than 60, but I read high could be pathologis

How do you feel?: The complement system is a chaotic system -- like the butterfly effect. Most-impacted by this is CH40. The CH50 test is subject to so many variables and artifacts that as long as you feel reasonably well and don't have some bizarre, mysterious illness, I wouldn't give an elevated value a second thought. Read more

5

5
I have normal levels of complement C2 and c4. C3 level is low. Ch50 is high-normal (57 u/ml)- (all are serum tests)-what are the possible causes?

Labwork: Proper medicine would be not to treat lab values but the patient. Based on the lab values you provided it is impossible to suggest any kind of diagnosis. We would need to know your presentation and other labwork that was done in order to help you sort it out. Read more

6

6
High positive ANA for years and now tested elevated complement C4 and C3 but all other autoimmune antibodies are still negative. What could that be?

High positive ANA for years and now tested elevated complement C4 and C3 but all other autoimmune antibodies are still negative. What could that be?

Inflammation: Complement is a phase reactant which means it will go up with any type of inflammation. It is not specific for any one problem. A low complement is of more concern. These lab texts could mean you will eventually develop an autoimmune disease or other disease process associated with ANA. They slso may never amount to anything. Read more

8

8
Esr, c3, c4, total hemolytic complement are all high, negative ana, malar rash, could it be lupus?

Esr, c3, c4, total hemolytic complement are all high, negative ana, malar rash, could it be lupus?

Very unlikely: Only a few patients with a malar rash on their cheeks have lupus. You have had appropriate laboratory tests and none are suggestive of lupus except the elevated esr, which is a very nonspecific measure of inflammation. See a dermatologist if you have done already done so. Read more

See 1 more doctor answer
10

10
Went for urinalysis test - all ok but complement C3 & C4 serum low and total IgA high. Hv hep c n cirohsis, low bp, taking diuretic. Pl advice?

Seriously sick: You know this. I'm glad you are alcohol-free. If you are a candidate for one of the new treatments to try to eliminate hepatitis c, please consider trying. The high IgA and the lowish complement components fit with your progressing liver disease. Your physician can advise you about medication. If the virus is eliminated, your liver will largely heal. Best wishes. Read more

12

12
Complement C4 is. 12 (normal is. 14 -.54) is it worth getting repeated.

Complement C4 is. 12 (normal is. 14 -.54) is it worth getting repeated.

Depends: Complement C4 being low could indicate an issue with activation of the complement system such as after infection. It could also be related to liver disease, genetic deficiency of complement, vasculitis, lupus, or even could possibly just be a low-normal value for you. So I would repeat testing only if you have other medical concerns that are currently being evaluated. Read more

See 1 more doctor answer
13

13
Anyone have lupus or know any information on C4 complement?

Anyone have lupus or know any information on C4 complement?

Low levels = bad: Rheumatologists measure C4 and C3 levels in lupus because low levels are seen in active disease. Read more

See 2 more doctor answers
14

14
My C4 complement level is low and C3 complement is at the low end of the range (90, ref range 90-180). What could this mean?

May be significant: Low Complement levels may be nonspecific markers for autoimmune disorders. Other symptoms and clinical findings are needed to be able to adequately answer your question. Read more

See 1 more doctor answer
15

15
What does it mean if my complement C3 serum was 4 points low on a scale of 90-180 and my C4 was normal? Could there be something wrong?

What does it mean if my complement C3 serum was 4 points low on a scale of 90-180 and my C4 was normal? Could there be something wrong?

Probably nothing: Decreased complement levels are seen in patients with active lupus. However, very minor abnormalities occur frequently, even in perfectly healthy individuals. These lab values must be viewed in the context of other lab studies and the clinical picture. Ask the physician who ordered the complement studies for his/her opinion as to the clinical relevance of this isolated lab abnormality. Read more

See 1 more doctor answer
16

16
Repeated blood tests show I have VERY low complement C3 @ 41 and not sure is C4 @ 12 is also considered low. What tests should be done next?

Repeated blood tests show I have VERY low complement C3 @ 41 and not sure is C4 @ 12 is also considered low. What tests should be done next?

Any symptoms?: Why were these tests done? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it needs to be kept in mind that complement proteins are labile and if the blood specimen is not handled properly, it may give inaccurate results. Would be prudent to get retested at a reputable lab. Read more

See 1 more doctor answer
17

17
Complement C3 & C4 tests done 3 times. C3 normal but twice C4 was borderline normal or borderline low, 3rd time it was well within range. Deficiency?

Why the tests?: If the values were either borderline low or borderline normal, then one would call the value low normal. Whether it means anything or not would depends on whether you have a disease condition associated with complement consumption. A low C4 is usually found in patients with hereditary angioedema. Read more

18

18
I have complement C3 n C4 deficient, ivr beem diagnosed with adult stills d. N fibro? Is deficiency in those to really rare?

I have complement C3 n C4 deficient, ivr beem diagnosed with adult stills d. N fibro? Is deficiency in those to really rare?

Not simple.: No association between still's & these complement deficiencies. C2 and C4 partial and complete defifiencies are not rare, affecting 1/200 people each. People with C2 and C4 deficiencies are more prone to diseases in the lupus family. C3 deficiencies are exceedingly rare and pose grave immune problems. The problem with low c2, c4, and C3 may reflect consumption of complement by vasculitis. Fms not! Read more

See 1 more doctor answer
20

20
Complement C3 and C4 tests done 3 times due to lupus symptoms. C3 always normal but C4 borderline low twice, now normal. Is this a deficiency?

Complement C3 and C4 tests done 3 times due to lupus symptoms. C3 always normal but C4 borderline low twice, now normal. Is this a deficiency?

Disease activity: I assume that the diagnosis of sLE has been confirmed. The concentration of C4 is much lower than C3. As C4 is ow normal, there is no deficiency. When sLE is active, C4 concentration may decrease because of it being used up by immune complexes in the blood. When disease activity lessens, less C4 is being used. Read more