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Doctor insights on: C3 And C4 Complement Levels

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Have borderline low C3 and C4 complement levels and low 1:80 titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?

Have borderline low C3 and C4 complement levels and low 1:80  titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?

Atypical for what?: Rheumatic disease generally requires a cluster of suggestive symptoms which is supported by lab studies. I do not know your symptoms, but your labs are not particularly suggestive of anything. ...Read more

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Dr. Jack Mutnick
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Dr. Warren Foster
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Complement Levels (Definition)

Total complement activity (CH50, CH100) looks at the overall activity of the complement system. Typically, other tests that are more specific for the suspected disease are performed first. C3 and C4 are the most commonly measured complement components. A complement test may be used to monitor patients with an autoimmune disorder and to see if treatment for their condition is working. For example, patients with active lupus erythematosus may have lower-than-normal levels of the complement ...Read more


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Have borderline low C3 and C4 complement levels and low 1:80 titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?

Atypical for what?: Rheumatic disease generally requires a cluster of suggestive symptoms which is supported by lab studies. I do not know your symptoms, but your labs are not particularly suggestive of anything. ...Read more

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Dr. Jack Mutnick
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11 years in practice
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My C4 complement level is low and C3 complement is at the low end of the range (90, ref range 90-180). What could this mean?

May be significant : Low Complement levels may be nonspecific markers for autoimmune disorders. Other symptoms and clinical findings are needed to be able to adequately answer your question. ...Read more

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Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels?...Or would low C3 or C4 show up on ch50 test?

Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels?...Or would low C3 or C4 show up on ch50 test?

CH50: Ch50 measures the terminal or classical pathway. Deficiency of this test requires further investigation. Low c3 and c4 levels suggest activation of the classical pathway. Low c3 and normal c4 levels suggest activation of the alternate pathway. C4 could be low with a normal ch50. ...Read more

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Dr. Jack Mutnick
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I have normal levels of complement C2 and c4. C3 level is low. Ch50 is high-normal(57 u/ml)-(all are serum tests)-what are the possible causes?

Labwork: Proper medicine would be not to treat lab values but the patient. Based on the lab values you provided it is impossible to suggest any kind of diagnosis. We would need to know your presentation and other labwork that was done in order to help you sort it out. ...Read more

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What does it mean if my complement C3 serum was 4 points low on a scale of 90-180 and my C4 was normal? Could there be something wrong?

What does it mean if my complement C3 serum was 4 points low on a scale of 90-180 and my C4 was normal? Could there be something wrong?

Probably nothing: Decreased complement levels are seen in patients with active lupus. However, very minor abnormalities occur frequently, even in perfectly healthy individuals. These lab values must be viewed in the context of other lab studies and the clinical picture. Ask the physician who ordered the complement studies for his/her opinion as to the clinical relevance of this isolated lab abnormality. ...Read more

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Complement C3 & C4 tests done 3 times. C3 normal but twice C4 was borderline normal or borderline low, 3rd time it was well within range. deficiency?

Why the tests?: If the values were either borderline low or borderline normal, then one would call the value low normal. Whether it means anything or not would depends on whether you have a disease condition associated with complement consumption. A low C4 is usually found in patients with hereditary angioedema. ...Read more

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Complement (Definition)

The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more


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Dr. Jack Mutnick
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