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Doctor insights on: C3 And C4 Complement Levels

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Have borderline low C3 and C4 complement levels and low 1:80 titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?

Have borderline low C3 and C4 complement levels and low 1:80  titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?

Atypical for what?: Rheumatic disease generally requires a cluster of suggestive symptoms which is supported by lab studies. I do not know your symptoms, but your labs are not particularly suggestive of anything. ...Read more

Dr. Ronald Krauser
13 doctors shared insights

Complement Levels (Definition)

Total complement activity (CH50, CH100) looks at the overall activity of the complement system. Typically, other tests that are more specific for the suspected disease are performed first. C3 and C4 are the most commonly measured complement components. A complement test may be used to monitor patients with an autoimmune disorder and to see if treatment for their condition is working. For example, patients with active lupus erythematosus may have lower-than-normal levels of the complement ...Read more

Dr. Maziar Rezvani
Board Certified, Allergy and Immunology
15 years in practice
767.0K people helped
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Dr. Maziar Rezvani
Board Certified, Allergy and Immunology
15 years in practice
767.0K people helped
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Vitamin D (Tip)

Vitamin D

Myth: vitamin d deficiency does not occur in young individuals. Fact: it can happen at any age. ...See more

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My C4 complement level is low and C3 complement is at the low end of the range (90, ref range 90-180). What could this mean?

My C4 complement level is low and C3 complement is at the low end of the range (90, ref range 90-180). What could this mean?

Lower immune system: Suggests that your immune system may not work optimally. You may be more inclined to infections. Some people also may have autoimmune disorders so you may want to consider having basic testing done for Lupus and similar type of diseases by simple blood tests. Although Lupus does require more than just a blood test to Diagnose. It has many criteria to look at. ...Read more

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Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels?...Or would low C3 or C4 show up on ch50 test?

Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels?...Or would low C3 or C4 show up on ch50 test?

CH50: Ch50 measures the terminal or classical pathway. Deficiency of this test requires further investigation. Low c3 and c4 levels suggest activation of the classical pathway. Low c3 and normal c4 levels suggest activation of the alternate pathway. C4 could be low with a normal ch50. ...Read more

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Chronic Back Pain (Tip)

Chronic Back Pain

Vitamin d deficiency can present with back pain. Vitamin d supplement can help improve symptoms. ...See more

Board Certified, Allergy and Immunology
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I have normal levels of complement C2 and c4. C3 level is low. Ch50 is high-normal(57 u/ml)-(all are serum tests)-what are the possible causes?

Labwork: Proper medicine would be not to treat lab values but the patient. Based on the lab values you provided it is impossible to suggest any kind of diagnosis. We would need to know your presentation and other labwork that was done in order to help you sort it out. ...Read more

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Could my severe vitamin d deficiency be the cause of my extremely high complement ch50 level? C3 and C4 are normal.

Could my severe vitamin d deficiency be the cause of my extremely high complement ch50 level?  C3 and C4 are normal.

No: I'd ignore the high ch50 levels. This is a lab test that's hard to do and even harder to interpret. ...Read more

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Preventing Prostate Cancer (Tip)

Preventing Prostate Cancer

Make sure your estrogen level is low and have adequate Progesterone level. ...See more

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What does it mean if my complement C3 serum was 4 points low on a scale of 90-180 and my C4 was normal? Could there be something wrong?

What does it mean if my complement C3 serum was 4 points low on a scale of 90-180 and my C4 was normal? Could there be something wrong?

Probably nothing: Decreased complement levels are seen in patients with active lupus. However, very minor abnormalities occur frequently, even in perfectly healthy individuals. These lab values must be viewed in the context of other lab studies and the clinical picture. Ask the physician who ordered the complement studies for his/her opinion as to the clinical relevance of this isolated lab abnormality. ...Read more

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Complement (Definition)

Complement is a component of the immune system. It is one of the back bones of the immune system that helps fight infections. Complement deficiencies can lead to infections and some complement deficiencies can even led to a disease involving life threatening swelling reactions. ...Read more

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Dr. Maziar Rezvani
Board Certified, Allergy and Immunology
15 years in practice
767.0K people helped
Continue
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