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Doctor insights on: C3 And C4 Complement Levels

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Dr. Dan Fisher
Board Certified, Internal Medicine
22 years in practice
78M people helped
1

1
Have borderline low C3 and C4 complement levels and low 1:80 titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?

Dr. Dan Fisher
Board Certified, Internal Medicine
22 years in practice
78M people helped
Have borderline low C3 and C4 complement levels and low 1:80  titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?

Atypical for what?: Rheumatic disease generally requires a cluster of suggestive symptoms which is supported by lab studies. I do not know your symptoms, but your labs are not particularly suggestive of anything. ...Read more

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Dr. Jane van Dis
Board Certified
13 years in practice
44M people helped
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Dr. Jane van Dis
Board Certified
13 years in practice
44M people helped
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Complement Levels (Definition)

Total complement activity (CH50, CH100) looks at the overall activity of the complement system. Typically, other tests that are more specific for the suspected disease are performed first. C3 and C4 are the most commonly measured complement components. A complement test may be used to monitor patients with an autoimmune disorder and to see if treatment for their condition is working. For example, patients with active lupus erythematosus may have lower-than-normal levels of the complement ...Read more


Dr. Dan Fisher
Board Certified, Internal Medicine
22 years in practice
78M people helped
2

2
Have borderline low C3 and C4 complement levels and low 1:80 titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?

Dr. Dan Fisher
Board Certified, Internal Medicine
22 years in practice
78M people helped

Atypical for what?: Rheumatic disease generally requires a cluster of suggestive symptoms which is supported by lab studies. I do not know your symptoms, but your labs are not particularly suggestive of anything. ...Read more

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Dr. Jane van Dis
Board Certified
13 years in practice
44M people helped
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Dr. Jane van Dis
Board Certified
13 years in practice
44M people helped
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Dr. Ronald Krauser
Board Certified, Rheumatology
47 years in practice
66M people helped
3

3
What illness could explain ELEVATED C3 and C4 complement serum levels in the presence of angioedema? ANA and Rheum Arth Factor both negative.

Dr. Ronald Krauser
Board Certified, Rheumatology
47 years in practice
66M people helped
What illness could explain ELEVATED C3 and C4 complement serum levels in the presence of angioedema? ANA and Rheum Arth Factor both negative.

See details: Elevated levels mean nothing. The test were done to see in the C4 level was low and therefore would suggest hereditary angioedema.. ...Read more

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Dr. Marsha Davis
Board Certified, Internal Medicine
23 years in practice
66M people helped
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Dr. Jane van Dis
Board Certified
13 years in practice
44M people helped
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Dr. Carla Enriquez
Board Certified, Adolescent Medicine
45 years in practice
19M people helped
5

5
My C4 complement level is low and C3 complement is at the low end of the range (90, ref range 90-180). What could this mean?

Dr. Carla Enriquez
Board Certified, Adolescent Medicine
45 years in practice
19M people helped

May be significant : Low Complement levels may be nonspecific markers for autoimmune disorders. Other symptoms and clinical findings are needed to be able to adequately answer your question. ...Read more

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Dr. Stevan Cordas
Board Certified, Internal Medicine
52 years in practice
6M people helped
6

6
Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels?...Or would low C3 or C4 show up on ch50 test?

Dr. Stevan Cordas
Board Certified, Internal Medicine
52 years in practice
6M people helped
Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels?...Or would low C3 or C4 show up on ch50 test?

CH50: Ch50 measures the terminal or classical pathway. Deficiency of this test requires further investigation. Low c3 and c4 levels suggest activation of the classical pathway. Low c3 and normal c4 levels suggest activation of the alternate pathway. C4 could be low with a normal ch50. ...Read more

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Dr. Pavel Conovalciuc
Board Certified, Family Medicine
18 years in practice
58M people helped
7

7
I have normal levels of complement C2 and c4. C3 level is low. Ch50 is high-normal(57 u/ml)-(all are serum tests)-what are the possible causes?

Dr. Pavel Conovalciuc
Board Certified, Family Medicine
18 years in practice
58M people helped

Labwork: Proper medicine would be not to treat lab values but the patient. Based on the lab values you provided it is impossible to suggest any kind of diagnosis. We would need to know your presentation and other labwork that was done in order to help you sort it out. ...Read more

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Dr. Ed Friedlander
Board Certified, Pathology
39 years in practice
137M people helped
8

8
Could my severe vitamin d deficiency be the cause of my extremely high complement ch50 level? C3 and C4 are normal.

Dr. Ed Friedlander
Board Certified, Pathology
39 years in practice
137M people helped
Could my severe vitamin d deficiency be the cause of my extremely high complement ch50 level?  C3 and C4 are normal.

No: I'd ignore the high ch50 levels. This is a lab test that's hard to do and even harder to interpret. ...Read more

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Dr. Neal Birnbaum
Board Certified, Rheumatology
46 years in practice
143K people helped
9

9
What does it mean if my complement C3 serum was 4 points low on a scale of 90-180 and my C4 was normal? Could there be something wrong?

Dr. Neal Birnbaum
Board Certified, Rheumatology
46 years in practice
143K people helped
What does it mean if my complement C3 serum was 4 points low on a scale of 90-180 and my C4 was normal? Could there be something wrong?

Probably nothing: Decreased complement levels are seen in patients with active lupus. However, very minor abnormalities occur frequently, even in perfectly healthy individuals. These lab values must be viewed in the context of other lab studies and the clinical picture. Ask the physician who ordered the complement studies for his/her opinion as to the clinical relevance of this isolated lab abnormality. ...Read more

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Dr. John Chiu
Board Certified, Allergy and Immunology
52 years in practice
21M people helped
10

10
Complement C3 & C4 tests done 3 times. C3 normal but twice C4 was borderline normal or borderline low, 3rd time it was well within range. deficiency?

Dr. John Chiu
Board Certified, Allergy and Immunology
52 years in practice
21M people helped

Why the tests?: If the values were either borderline low or borderline normal, then one would call the value low normal. Whether it means anything or not would depends on whether you have a disease condition associated with complement consumption. A low C4 is usually found in patients with hereditary angioedema. ...Read more

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Dr. Jane van Dis
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