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Doctor insights on: C2 Complement Component

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I have anemia, vitamin d deficient, positive ANA test, high sed rate, body aches, complement component c3c is 220, c4c is 51, c-reactive is .97explain?

I have anemia, vitamin d deficient, positive ANA test, high sed rate, body aches, complement component c3c is 220, c4c is 51, c-reactive is .97explain?

More than one issue: You did not state your age or gender and it is difficult to tie all the findings together without a physical examination. Vitamin d is the easiest to deal with, about 1/3 of the population has low vit d levels, and you can correct that with an over the counter supplement. Rest of the finding suggest and autoimmune process, but you need to consult a physician for a thorough evaluation. ...Read more

Complement (Definition)

The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more


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I have anemia, vitamin d deficient, positive ANA test, high sed rate, body aches, complement component c3c is 220, c4c is 51, c-reactive is .97explain?

More than one issue: You did not state your age or gender and it is difficult to tie all the findings together without a physical examination. Vitamin d is the easiest to deal with, about 1/3 of the population has low vit d levels, and you can correct that with an over the counter supplement. Rest of the finding suggest and autoimmune process, but you need to consult a physician for a thorough evaluation. ...Read more

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I have normal levels of complement C2 and c4. C3 level is low. Ch50 is high-normal(57 u/ml)-(all are serum tests)-what are the possible causes?

I have normal levels of complement C2 and c4.  C3 level is low.  Ch50 is high-normal(57 u/ml)-(all are serum tests)-what are the possible causes?

Labwork: Proper medicine would be not to treat lab values but the patient. Based on the lab values you provided it is impossible to suggest any kind of diagnosis. We would need to know your presentation and other labwork that was done in order to help you sort it out. ...Read more

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Anyone have lupus or know any information on C4 complement?

Anyone have lupus or know any information on C4 complement?

Low levels = bad: Rheumatologists measure c4 and c3 levels in lupus because low levels are seen in active disease. ...Read more

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I have complement C3 n C4 deficient, ivr beem diagnosed with adult stills d. N fibro? Is deficiency in those to really rare?

I have complement C3 n C4 deficient, ivr beem diagnosed with adult stills d. N fibro? Is deficiency in those to really rare?

Not simple.: No association between still's & these complement deficiencies. C2 and c4 partial and complete defifiencies are not rare, affecting 1/200 people each. People with c2 and c4 deficiencies are more prone to diseases in the lupus family.C3 deficiencies are exceedingly rare and pose grave immune problems. The problem with low c2, c4, and c3 may reflect consumption of complement by vasculitis. Fms not! ...Read more

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Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels?...Or would low C3 or C4 show up on ch50 test?

Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels?...Or would low C3 or C4 show up on ch50 test?

CH50: Ch50 measures the terminal or classical pathway. Deficiency of this test requires further investigation. Low c3 and c4 levels suggest activation of the classical pathway. Low c3 and normal c4 levels suggest activation of the alternate pathway. C4 could be low with a normal ch50. ...Read more

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What is the definition or description of: complement?

What is the definition or description of: complement?

Complement System: The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by natural "tick-over" of C3. ...Read more

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What foods complement each other well nutritionally?

What foods complement each other well nutritionally?

Whole foods: If you want the best nutritionally rich diet, stick with whole foods, fruits, vegetables, nuts, seeds, and grain. Avoid animal protein and dairy. ...Read more

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Can you tell me about immunobiology - complement cascade?

Textbook: This is a subject which should be studied with a textbook. Briefly complement is a system whereby the body kills off offenders. However there are check-and-balance system to make sure that it does not go too far leading to unwanted tissue damages. ...Read more