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Doctor insights on: C1 Esterase Inhibitor

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Can you tell me in myasthenia gravis why do you give an acetylcholine esterase inhibitor instead of a direct receptor agonist?

Can you tell me in myasthenia gravis why do you give an acetylcholine esterase inhibitor instead of a direct receptor agonist?

Because...: If you provide an agonist your muscles will contract continually. The acetylcholine esterase inhibitor prolongs the life of acetylcholine released naturally from your motor nerves so you only have muscle contraction when your brain orders it. ...Read more

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C1 Esterase Inhibitor Panel had two functional and one protein level. The protein level was 11 (20-40 ml/dL). What does that mean? Other two normal.

C1 Esterase Inhibitor Panel had two functional and one protein level. The protein level was 11 (20-40 ml/dL). What does that mean? Other two normal.

Makes no sense: C1INH assays may show low C1INH (which you appears to have) or normal C1INH level with impaired functioning if you are looking for the typical cases of hereditary edema. If the quantity is low, there cannot be normal functioning. If you do have HAE, treatment should be started promptly to prevent throat swelling. ...Read more

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Can CH50 & C1 Esterase Inhibitor be WNL with decreased C3/C4 levels? I've been diagnosed with Anemia, Gatroparesis, SLE & MCTD to date

Can CH50 & C1 Esterase Inhibitor be WNL with decreased C3/C4 levels? I've been diagnosed with Anemia, Gatroparesis, SLE & MCTD to date

Yes, 2 different : Conditions, and low C3/C4 is due to complement consumption in autoimmune diseases as SLE or MCTD. CH50 is the mean of hemolytic complement, and is low in complement defiency, rare, while C1 Esterase is deficient manly in Hereditary Angioedema, all not related to SLE / MCTD, wish you all the best ...Read more

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Can you tell me in myasthenia gravis why do you give an acetylcholine esterase inhibitor instead of a direct receptor agonist?

Because...: If you provide an agonist your muscles will contract continually. The acetylcholine esterase inhibitor prolongs the life of acetylcholine released naturally from your motor nerves so you only have muscle contraction when your brain orders it. ...Read more

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If u get a steroid tendon inj & r taking a cyp450 3a4 inhibitor at the same time is it like getting 3 steroid injections?

If u get a steroid tendon inj & r taking a cyp450 3a4 inhibitor at the same time is it like getting 3 steroid injections?

No: It is still one steroid injection. Biotransformation in liver is important for drugs given trough mouth, im and IV since those effect depend on concentration of drug in blood. Liver (and p450 enzyme system) has relatively little effect on drugs injected in joints, epidural space, tendons, body cavities. ...Read more

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Can you tell me what the ACE inhibitor is?

Can you tell me what the ACE inhibitor is?

Type of BP med: An ace inhibitor, or angiotensin-converting enzyme inhibitor, is a type of blood pressure medication to control high blood pressure. ...Read more

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Why do lipase inhibitors not stop 100% of the fat?

Why do lipase inhibitors not stop 100% of the fat?

Not enough amounts: Quantity and concentration related, and you get nasty foul smelling greasy stools. ...Read more

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Are 'aromatase inhibitors' healthy to take regularly?

Are 'aromatase inhibitors' healthy to take regularly?

Maybe but for what?: All medications, prescription & otc, as well as all dietary supplements, have potential side effects. There is no free lunch, no side effect free pill, whether medication or supplement. Aromatase inhibitors are approved for use in breast cancer in which case the potential risk of liver damage, hypertension, etc probably outweighs risk of recurrent breast cancer. So talk to your doc re what's right. ...Read more

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Is the selective norepinephine reuptake inhibitor, reboxetine, effective?

Is the selective norepinephine reuptake inhibitor, reboxetine, effective?

Evidence says not: One meta-analysis* (a study pooling results from multiple other studies) suggested that reboxetine is ineffective & may be harmful. *(eyding d et. Al. "Reboxetine for acute treatment of major depression: systematic review &meta-analysis of published &unpublished placebo &selective serotonin reuptake inhibitor controlled trials."bmj. 2010; 341:c4737). ...Read more

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Any over-the-counter aromatase inhibitors?

No: There are no over the counter aromatase inhibitors. They are only available by prescription. ...Read more

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Why pde5 inhibitor cannot taken with nitrate? Thanks

Why pde5 inhibitor cannot taken with nitrate? Thanks

Severe Interaction: This combination phosphodiesterase inhibitor (pde5) + nitrate has been shown to cause a drastic drop in blood pressure (hypotension) a medical emergence that can result to death. Really deaths have been reported with this combination. Pde5 (some drugs in this class include viagra, (sildenafil) cialis, levitra). ...Read more

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When should someone take selective serotonin re-uptake inhibitors?

Depression: These medications are usually a first line medication for depression although they have other uses. ...Read more

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Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

TCA/SSRI: Both are, depending on what they are prescribed for. The difference is in tolerability & side-effects. ...Read more

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What is an inhibitor for the cyp2c8 (mainly involved in actos (pioglitazone) metabolism)?

What is an inhibitor for the cyp2c8 (mainly involved in actos (pioglitazone) metabolism)?

Liver enzyme: The cyp2c8 enzyme contributes to the metabolism of many drugs. This enzyme consists of less than 10% of the total cytochrome components in the liver, though has also been found in other organs. Even if inhibited, other pathways are available to metabolize drugs which helps the body avoid toxic build- up of drug metabolites. ...Read more

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Why do ACE inhibitors cause hyperkalemia?

Why do ACE inhibitors cause hyperkalemia?

Block aldosterone: The primary mechanism of action of an ace inhibitor is to interrupt the renin angiotensin system. One of the results is reduced aldosterone synthesis. Aldosterone is an important hormone responsible for regulating potassium excretion by the kidney. Thus blocking aldosterone reduces the capacity of the kidney to excrete potassium. ...Read more

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How do ACE inhibitors reverse microalbuminuria?

How do ACE inhibitors reverse microalbuminuria?

Unclear: I don't believe that the mechanism is well understood but they do act on the renal glomerulus, improving membrane integrity, reducing protein leakage, and thus do help microalbumenuria. In addition, they also lower blood pressure which is also beneficial. ...Read more

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Asthma question. How do leukotriene inhibitors work?

Asthma question. How do leukotriene inhibitors work?

Prevention: Leukotriene is one of chemical mediators responsible for airway inflammation and bronchospasm leading to airway obstruction when asthma flares up. Singulair (montelukast) and accolate, known as leukotriene inhibitors, therefore prevent or reduce flare-ups. ...Read more

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Is there any hair inhibitor cream or lotion exits that actually works? Like kalo, hair away?

Grooming: Unfortunately the doctors here on health tap do not endorse or promote any products. And, second, one does not go to the doctor to learn how to groom. Maybe your girlfriends will have some opinions on this. But, medicine will remain neutral on your question. ...Read more

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What are proton pump inhibitors?

What are proton pump inhibitors?

Acid blockers : They block the formation of acid in the stomach. ...Read more

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What do proton pump inhibitors do?

What do proton pump inhibitors do?

PPI's treat ulcers: Antacids neutralize acid that has already been produced, & as such has value in providing immediate relief of indigestion. H2 blockers & proton pump inhibitors block acid production & are best used to heal peptic disease & address acid reflux. Ppi's also protect against nsaid-related injury. ...Read more

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Protein pump inhibitor side effects?

Protein pump inhibitor side effects?

Nausea diarrhea : There are many like all drugs. They are not to be used for long term. ...Read more

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Can I use lipase inhibitors for weight loss?

Can I use lipase inhibitors for weight loss?

Can, but: Lipase inhibitors may be used as one item loss, keeping in mind the side effects, such as diarrhea, anal leakage, bloating, mal-absorption of fat soluble vitamins etc. Better option is to limit caloric intake and increase physical activity. ...Read more

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Can you tell me about hiv-1 protease inhibitor?

Can you tell me about hiv-1 protease inhibitor?

See below: Please consult this site for information on this topic.
http://www.webmd.com/hiv-aids/protease-inhibitors-pis-for-hiv ...Read more

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Will tnf-alpha inhibitor work against boneloss?

Will tnf-alpha inhibitor work against boneloss?

In rheum. arthritis?: Osteoporosis is a known complication of rheumatoid arthritis (ra). The bone loss is related to features of the patient (usually a postmenopausal woman), corticosteroid therapy, and the underlying arthritis disease. May have a beneficial effect on bone loss through the medication's strong anti-inflammatory effect. ...Read more

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How are lipase inhibitors used for weight loss?

How are lipase inhibitors used for weight loss?

Orlistat: Orlistat is lipase inhibiter and is used to lose weight in over weight individuals with low fat, low calorie diet and exercise. So fat is in not absorped in its entirity and is passed undigested in stools. So total calorie absorption is reduced and because of the side effects which are not pleasant people cut down on their fat intake and that helps too. ...Read more

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How do I ween myself off proton pump inhibitors?

How do I ween myself off proton pump inhibitors?

Weening: Possibly start by going every other day for 1-2 weeks, then 1 every 2 days for 1-2 weeks. If you get rebound reflux, you can use Pepcid (famotidine) or Tums as needed. Finally, you may be able to be off it. Also, if you can change your diet and eat smaller meals that may help some. Always refer to your physician for proper instructions. ...Read more