Doctor insights on:
C Kit Mutation Cell Based
In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more
Can one's DNA change during life? Does that mean that different cells in my body might currently have mutations from one another?
Unregulated growth: The "cell clock" is often referred to as the cell cycle. Think of this as a series of stop and go lights during the lifetime of a cell. Mutations can change a "stop light" to a "green light" resulting in unregulated growth of cells. That unregulated growth can result in the cancer. ...Read more
Thyroseq v2 was mutations NOT detected but analysis limited due to low amount of thyroid epithelial cells.So this test was useless?
Totally: B"sd absolutely right - genetic studies should only be done on an appropriate tissue specimen. To my knowlege, specimens are screened for adequacy before such testing. If the biopsy was indicated in the first place then it must be repeated - usually after an appropriate interval to allow the "needled" tissue to heal. ...Read more
Thyroseq neg for mutations But interpret with caution due to marginally low expression of thyroid cell specific markers.Odds higher for benign nodule?
Is it safe to use kojic acid soap? I've heard that it can cause cell mutation on some mammals. I would plan to use it once a day each night.
Sickle cell anemia: There are many different types of sickle cell anemia. How bad someone's disease is depends on which part of africa their family originally came from and whether the sickle cell gene is combined with any other hemoglobin mutations. For instance, sickle cell + hemoglobin c or sickle cell + thalassemia often gives the patient milder disease than plain sickle cell anemia. ...Read more
It doesn't appear so: I can find no reports of an association between sickle cell anemia and jak2 mutations. Jak2 is a gene involved in promoting growth of red blood cells. The confusion may have arisen from some reports suggesting that stimulators of jak2 might be useful in gene therapy treatments for sickle cell disease. ...Read more
Kras ?Adenocarcinoma? Mutation? New trial drugs with Ins. & Tissue Eval. What is the doctor really saying to 70 year NSCLC pat.9 month ..meets w/new cell grow
Describing the Tumor: So it sounds like the oncologist has really just given you a lot of descriptors to help describe the tumor. The idea is that if we know this information we can select therapies that are more likely to work. For example, whether a patient has a k-ras mutation helps predict whether a tumor may be resistant to a certain drug. ...Read moreSee 2 more doctor answers
Important gene...: Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin. Hemoglobin allows red blood cells to carry oxygen from your lungs to all parts of your body. In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. These abnormal red blood cells lead to the various symptoms of the disease. ...Read moreSee 1 more doctor answer
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