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Doctor insights on: C Diff Antigen Positive Toxin Negative

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Should u be on treatment if u tested positive for c diff toxin b & antigen by pcr. But have no diaherra?

Should u be on treatment if u tested positive for c diff toxin b & antigen by pcr. But have no diaherra?

C.diff: Asymptomatic carrier state is known to occur with c.Diff. Carriers actively excrete bacteria in stool. However there is not enough studies that treating asymptomatic carriers have any benefit. Hence, the current recommendation is not to treat. You can try using probiotics to improve colonic flora and possibly eliminate the c.Diff though this has not proven to always happen. ...Read more

Toxin (Definition)

Poisonous substance produced within living cells or organisms;man-made substances created by artificial processes are thus excluded. The term was first used by organic chemist ludwig brieger (1849–1919). For a toxic substance not produced within living organisms, "toxicant" and "toxics" are also sometimes used.[citation needed]. Toxins can be small ...Read more


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Clostridium difficile toxin b gene present clostridium dificile antigen presen. Would u no how severe the c diff is?

Clostridium difficile toxin b gene present
clostridium dificile antigen presen. Would u no how severe the c diff is?

Have diarrhea or no?: C.Difficile is pathogenic in older children & adults (whose colonic microflora are altered by antibiotics, chemotherapy, salmonella/shigella). C.Diff causes diarrhea w/pseudomembranous & other colitis, complicates inflammatory bowel disease, causes fulminant transmural extension, perforation with peritonitis, toxic megacolon. Treatment, & confirmation of post-treatment eradication, is recommended. ...Read more

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Had clostridium difficile, toxin a and b. Was cured and test show all are negative. Diarrea continues what can I do?

Retest: If you had confirmed c diff and diarrhea has returned following treatment then you likely have recurrence. The stool studies are not 100% accurate. ...Read more

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No diaherra but positive for c diff toxin b. Do i need treatment? Most i get is mild cramps. & slight temp. 99.8. For a bit then normal

No diaherra but positive for c diff toxin b. Do i need treatment? Most i get is mild cramps. & slight temp. 99.8. For a bit then normal

Doctors advice: Not sure where the disconnect is here. We are not here to provide treatment or to interfere with the doctor providing you care. Asking us the asme question over and over is unnecessary. Take the medicine your physician recommends and be done with this. You have an infection and a fever! ...Read more

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If i'm a carrier of c diff & had a stool test done. Would toxins show up in test? I no most docs are carriers. Would they test positive if tested.

Don't worry: Clostridium difficile is ubiquitous, many (maybe most) people have a few of these among the hundreds of different species in the gut, and trying to detect (let alone treat) these people serves no public good and generates only fear and superstition. Cdc guidelines http://www.Cdc.Gov/hai/pdfs/cdiff/cohen-idsa-shea-cdi-guidelines-2010.Pdf. ...Read more

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I was told the c diff toxin screen came back positive. I don't have diarrhea or other symptoms. They still want to treat me with antibiotics. Can us b?

I was told the c diff toxin screen came back positive. I don't have diarrhea or other symptoms. They still want to treat me with antibiotics. Can us b?

Carrier: Carriers of c diff, even though they have no symptoms, can transmit the infection. Unless they are in a hospital or nursing home, they often are not treated but advised to be very careful about hygiene after bowel movements. A consultant in infectious diseases can advise you best on whether you should be treated. ...Read more

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How many days after being off treatment can u get retested for clostridium difficile colitis to see if positive or negative.

Usually not: Re-tested as a matter of routine. If you are not better after the prescribed course of treatment then see your doctor or gastroenterologist asap for a re-evaluation of your condition. Don't wait to get more ill or dehydrated. ...Read more

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What other way can a baby be positive for toxigenic c. Diff, if mother is negative and if he hasnt been on antibiotic?

What other way can a baby be positive for toxigenic c. Diff, if mother is negative and if he hasnt been on antibiotic?

Cl. difficile: This organism may have been acquired in the colon during hospitalization at time of delivery, somebody in family may be carrying it and transmitted it, or the testing of the mother is not accurate. ...Read more

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I have diarrhea, bleeding, abd pain/bloating, nausea 1 yr. Norm upper/lower GI, neg ova/parasite tests, positive c diff. Can c diff last that long?

I have diarrhea, bleeding, abd pain/bloating, nausea 1 yr. Norm upper/lower GI, neg ova/parasite tests, positive c diff. Can c diff last that long?

Yes!: If you have above symptoms and past history of C Diff- sometimes it can be antibiotic resistant strain . You should be retested and seek medical attention ASAP! Besides it nutrition is very important: eat daily high dose probiotic food ( KEFIR, Greek plain Yogurt, Danactive, Lassi) and pod supplement as VSL#3 450-900 billions bacteria. Keep hydrated. Don't procrastinate to see doctor. ...Read more

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Hepb surface antigen positive, confirmatory test negative, antibody and core negative, should I worry?

Hepb surface antigen positive, confirmatory test negative, antibody and core negative, should I worry?

Possibly: Do not understand how initial test was positive and "confirmatory" test negative. Need to repeat these, although you may be in the "window" period, when antigen is being consumed by forming antibody and neither is measurable. Wait 3 months and retest antibody titers. By then you may be hepb antibody and core antibody positive, in which case you are immune. ...Read more

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My hepb surface antigen is positive but hepb sag confirmation is negative also anti core and antibody negative , what does it mean?

Hepatitis B immunity: It sure sounds like you were immunized against hepatitis b. This began happening in the early 1980s for all children in america. Given your age it was most likely one of the pediatric vaccinations you got. ...Read more

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Is it possible to test positive for hiv 25 days after possible exposure? I had an antigen and antibodies test done which came back negative.

Is it possible to test positive for hiv 25 days after possible exposure? I had an antigen and antibodies test done which came back negative.

Too soon to rule out: A negative result at this stage does not exclude HIV infection. It some times take unto a year for antibody test to turn positive. You should get HIV nucleic acid test done about 3 months after the exposure and if that is negative you are essentially without HIV. ...Read more

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My hep b surface antigen is positive but conformation test is negative, also all other test hsbc antibody and core negative , is it a false report?

My hep b surface antigen is positive but conformation test is negative, also all other test hsbc antibody and core negative , is it a false report?

Hepatitis B: R u certain the positive test was surface antigen & not surface antibody? The data u give don't fit the typical test results (see image). Perhaps the results were incorrectly reported to u. Check with doc who ordered tests. ...Read more

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Hi please help, hepb surface antigen positive, hep b surface antigen confirmatory negative, antibody negative and anti core negative.What does it mean?

Hepatitis B testing: You should have it rechecked. Hbsag or surface antigen tests are the same, not like in HIV which has screening and confirmatory test. Normally, in the window period after an acute infection, all test for surface antigen or its antibodies are negative except for antibody to core antigen. Hbsag or surface antigen appears right after infection or exposure and disappears in recovery. ...Read more

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Can I test neg to hep b virus n test positive to hep b antigen? And why

Can I test neg to hep b virus n test positive to hep b antigen? And why

Restate: Restate question. hepatitis B antibody which is positive after vaccine or have recovered developing immunity to the infection which means you have immunity.Hepatiis B antigenand hepatitis core antibody are positive during infection.After acute hepatitis B infection about 10 to 20% of people develop a chronic hepatitis B infection. You can do a HealthTap visit with copy of your lab for diagnosis ...Read more

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Dengue ns1 antigen is non reactive but dengue igm is positive and igg is negative. what does this mean?

Dengue ns1 antigen is non reactive but dengue igm is positive and igg is negative. what does this mean?

Plan: For professional answer these results need to be discussed with doctor, who knows your medical history and symptoms. Specific antibodies various on different stage of disease. ...Read more

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I am pregnant 7 month. I check my blood. Result come anti HIV positive. After i check p24 antigen. P24 antigen result come negative. So i had HIV ?

I am pregnant 7 month. I check my blood.
Result come anti HIV positive. After i check p24 antigen. P24 antigen result come negative. 
So i had HIV ?

...: Given your test results are unclear, and that you are pregnant, it would be best to ask your doctor about getting tested for presence of HIV in your blood through a test called HIV RNA viral load. This checks to see if there is direct evidence of the virus and tells how much virus is in body (if any). ...Read more

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I tested negative for hep b antigen after 100 days french kiss exposure and positive for antibody 70 QN due vaccination baby is it conclusive thanks?

I tested negative for hep b antigen after 100 days french kiss exposure and positive for antibody 70 QN due vaccination baby is it conclusive thanks?

No risk, no worries: You are immune to hepatitis B virus (HBV) due to being vaccinated. With without vaccination, kissing rarely if ever transmits HBV so you weren't at risk anyway. And your negative HBsAg test proves you weren't infected. Your repeated questions show you're irrationally obsessed with this. Consider counseling. (Apologies if you're not same as previous questions.) ...Read more

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Hello doctor, I did a test for antibody HIV+ antigen p24 and i got 0.25 as a result, the test mentioned that (0.9<- negative) (1>=- positive) (0.9-1 b?

Hello doctor,
I did a test for antibody HIV+ antigen p24 and i got 0.25 as a result, the test mentioned that (0.9<- negative) (1>=- positive) (0.9-1 b?

Negative result: If any result less than 0.9 is negative, and the result one got is 0.25, that is a negative result (because 0.25 is less than 0.9). One should always do only safe activities (safe sex) if one worries about catching HIV, or if one gets possible exposures to HIV. ...Read more

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Erosive gastritis. h.pylori blood test positive, breath test positive, stool antigen test negative, biopsy negative. what to do ?

Erosive gastritis. h.pylori blood test positive, breath test positive, stool antigen test negative, biopsy negative.  what to do ?

Treat it: The positive H. pylori antibody test is not a reliable indicator of current infection. The gold standard for H. pylori treatment is the gastric biopsy, and this is negative in this patient. However, I am impressed by the positive breath test and erosive gastritis. I would have expected stool antigen to be positive, as it mirrors the breath test. Given the discrepant results, treat the patient. ...Read more

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Donated blood said hlab27 antigen positive PCP had blood drawn hlab27 negative. joint pain everywhere. weight gain headaches weakness tingling hands?

Donated blood said hlab27 antigen positive PCP had blood drawn hlab27 negative.  joint pain everywhere.  weight gain headaches weakness tingling hands?

Cannot be: HLA- B27 is always positive or negative. It does not change. One of the tests was wrong. Also, HLA-B27 is useless as a screening test. The symptoms need to be worked up (eg., the joint pain) and then, only the proper tests should be done depending on the symptoms. Diseases such Lyme disease or lupus cannot be checked for with labs. A history & physical are the first steps. ...Read more

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Ur thoughts? Docs said i got small case of c. Diff. Said meds will fix me. Not worried. To me they don't seem to concerned. Toxin b present.

Ur thoughts? Docs said i got small case of  c. Diff. Said meds will fix me. Not worried. To me they don't seem to concerned. Toxin b present.

C. difficile: We have responded to this at length. As indicated before, you may want to discuss this with an id doctor. Whether toxin a or b is still present (or toxin c) is unimportant if you are recovering clinically with decreased stooling and formed stools. Your symptoms suggest possible dehydration and electrolyte changes from the diarrhea. Good luck. Hope this is better soon. ...Read more

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Which c. Diff toxins are worse. Toxin a or b? Can the toxins affect your brain or other origins

Which c. Diff toxins are worse. Toxin a or b?  Can the toxins affect your brain or other origins

C diff toxins: Toxin b is much moretoxic, but doesnt seem to work if toxin ais not present. There have been no reports ofbrain involvement to my knowlege. ...Read more

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Can you get proctitis from C. diff, and what PCR testing should be done on Toxin A or B or both?

Yes: Proctitis is an inflammation of the lining of the rectum. In regards to the toxins, both are generally secreted (but B is essential for virulence). Enzyme immunoassay, polymerase chain reaction and cell cytotoxicity assays are used. If you don't have diarrhea, you don't have Cdiff..and in fact the lab won't even process the sample. Leave it up to your PCP or GI what test is appropriate. ...Read more

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Had some loose fluffy mushy bms for a week. Got tested and only thing that came back was c diff toxin b. However it don't smell. Infection or not?

C difficile: Clostridium difficile can be a potentially dangerous infection of the colon, often associated with prior use of antibiotics. It can cause a colitis or infection of the colon. Treatment is needed with antibiotics for this condition. ...Read more

Antigen (Definition)

Antigens are chemicals which upon exposure to the surface or inside of the body, will cause a reaction term allergic. Many substances will do this and allergic response is the basis for immunological protection for ...Read more


Dr. Stephen Scholand
452 doctors shared insights

Clostridium Difficile (Definition)

C. Diff, it is a spore forming bacillus that when the micro environment of the colon is modified by antimicrobials, it can germinate and elaborate a toxin causing pseudo membranous colitis, ...Read more