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Doctor insights on: Brittle Bone Disease Collagen Vascular Diseases

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Where do collagen vascular diseases show up?

Where do collagen vascular diseases show up?

Different areas: Collagen vascular diseases or multi-system diseases are just that. They are a group of diseases characterized by autoimmune aberrations. Varied organ systems can be involved - skin, joints or any internal organs - heart, kidneys, blood or nervous system. The way a disease presents itself depends on which areas are involved. See you doctor or rheumatologist. ...Read more

Dr. Christopher Bibb
42 doctors shared insights

Collagen Vascular Disease (Definition)

Collagen vascular diseases are a variety of conditions that involve disorders of collagen. Collagen is a tough, glue-like protein that makes up 30% of body protein. It shapes the structure of tendons, bones, and connective tissues. Problems with the immune system can affect these structures, and lead to conditions such as Rheumatoid Arthritis, Scleroderma, and ...Read more


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What's the significance of collagen vascular diseases?

Can be autoimmune: Collagen vascular disease encompasses a series of autoimmune illnesses such as lupus, rheumatoid arthritis, polymyositis and scleroderma to name a few. Each of these can have variations on their diagnostic categories. These were first named becuase there were similar changes in the soft tissues and blood vessels when biopsies were done in people with a collagen vascular diseases. ...Read more

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What are the concerns with having collagen vascular diseases?

DIFFICULT ANSWER: Collagen vasular diseases include a broad spectrum of illnesses. As a rheumatologist, we do our best to isolate what collagen vasular disease a patient has. The term, collagen vascular disease does not descibe one disease but rather the whole practice of rheumatology. I figure your doctor may have found an abnormal boold test which may or may not be significant. I need more information to help you. ...Read more

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Can I get my baby tested for brittle bone disease?

Can I get my baby tested for brittle bone disease?

Severe cases evident: The more severe cases are evident before birth by ultrasound & or neonatal x-rays.Classification of lesser forms are based on age of first symptoms or specialized testing. My last case involved a skin biopsy and analysis of enzyme production in a specialty lab. Have your dr locate a genetics department at a med school or children's hospital if you want to pursue this testing. They can set it up. ...Read more

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With brittle bone disease and kidney failure, is this fatal?

With brittle bone disease and kidney failure, is this fatal?

Not necessarily,: If kidney failure means on dialysis it is worse than if not on dialysis. At any rate need to control your phosphate levels and take your meds as prescribed to control you bone disease so no hip fracture will occur which will increase mortality. Control phosphate by no dairy products and control bean/ legume intake. Also, no cola including dr. Pepper, but root beer is okay. ...Read more

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Hypermobile, poor healing, broken bones from cycle accidents. Need tests for brittle bone disease?

Hypermobile, poor healing, broken bones from cycle accidents. Need tests for brittle bone disease?

Collagen issue: Sounds more like a collagen issue. Unfortunately there not a treatment for poor collagen like there is for osteo-porosis. Still worth getting bone density, electrolytes, and hormones checked. (thyroid, para thyroid). ...Read more

Dr. Linda DiMeglio
70 doctors shared insights

Brittle Bone Disease (Definition)

Osteogenesis imperfecta is a condition causing extremely fragile bones. Osteogenesis imperfecta (OI) is a congenital disease, meaning it is present at birth. It is frequently caused by defect in the gene that produces type 1 collagen, an important building block of bone. There are many different defects that can affect this gene. The severity of OI depends on ...Read more


Dr. Tiffanie Noonan
95 doctors shared insights

Osteogenesis Imperfecta (Definition)

Osteogenesis imperfecta is a condition causing extremely fragile bones. Osteogenesis imperfecta (OI) is a congenital disease, meaning it is present at birth. It is frequently caused by defect in the gene that produces type 1 collagen, an important building block of bone. There are many different defects that can affect this gene. The severity of OI depends on ...Read more