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Doctor insights on: Brittle Bone Disease

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Dr. Linda DiMeglio
70 doctors shared insights

Brittle Bone Disease (Overview)

Osteogenesis imperfecta is a condition causing extremely fragile bones. Osteogenesis imperfecta (OI) is a congenital disease, meaning it is present at birth. It is frequently caused by defect in the gene that produces type 1 collagen, an important building block of bone. There are many different defects that can affect this gene. The severity of OI depends on the specific gene defect.


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What is the official name for brittle bone disease?

What is the official name for brittle bone disease?

Brittle Bone Disease: Brittle bone disease is known as osteogenesis imperfecta. There are several different forms of oi. ...Read more

Dr. Linda DiMeglio
70 doctors shared insights

Brittle Bone Disease (Overview)

Osteogenesis imperfecta is a condition causing extremely fragile bones. Osteogenesis imperfecta (OI) is a congenital disease, meaning it is present at birth. It is frequently caused by defect in the gene that produces type 1 collagen, an important building block of bone. There are many different defects that can affect this gene. The severity of OI depends on the specific gene defect.


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Living with Coronary Artery Disease (Checklist)

Take meds as prescribed
Once
Exercise daily as recommended by your doctor or trainer
daily
Limit meat, dairy, and fats as much as possible
Once
Eat whole grains only - not white bread
Once
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Hypermobile, poor healing, broken bones from cycle accidents. Need tests for brittle bone disease?

Hypermobile, poor healing, broken bones from cycle accidents. Need tests for brittle bone disease?

Collagen issue: Sounds more like a collagen issue. Unfortunately there not a treatment for poor collagen like there is for osteo-porosis. Still worth getting bone density, electrolytes, and hormones checked. (thyroid, para thyroid). ...Read more

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Living with Sickle Cell Disease (Checklist)

Keep doctor's appointments
Once
Go to lab appointments
Once
Keep oxygen up by maintaining low weight, no smoking
Once
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Can you tell me how is brittle bone disease being treated with stem cells?

Clinical trials: Mesenchymal stem cells which can be isolated from bone marrow and other tissues are being infused into patients with osteogenesis imperfecta (oi) to see if they can cause normal bone growth. Active clinical trial here: http://clinicaltrials.Gov/ct2/show/nct01061099?Cond=%22osteogenesis+imperfecta%22;rank=1 more general info here: http://ghr.Nlm.Nih.Gov/condition/osteogenesis-imperfecta. ...Read more

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What is the treatment for brittle bone disease?

What is the treatment for brittle bone disease?

Symtomtic treatment: We have to treat people according the fractures they have. ...Read more

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Living with Celiac Disease (Checklist)

Schedule a visit with a dietitian
Once
When eating out, inform your waitstaff you are intolerant of gluten
Once
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Is brittle bone disease genetic?

Usually: Osteogenesis imperfecta is a disorder of brittle bones. There is an abnormality in collagen 1 function, and so you are not able to make bones or other connective tissue structures correctly. This is why people often have "blue sclera" because the collagen is abnormal. Most cases are genetic, but a new mutation (not inherited) can be seen (about 35%). ...Read more

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Dr. Oscar Novick
95 doctors shared insights

Osteogenesis Imperfecta (Definition)

Osteogenesis imperfecta is a condition causing extremely fragile bones. Osteogenesis imperfecta (OI) is a congenital disease, meaning it is present at birth. It is frequently caused by defect in the gene that produces type 1 collagen, an important building block of bone. There are many different defects that can affect this gene. The severity of OI depends on ...Read more


Bone (Definition)

Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more