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Doctor insights on: Breast Cancer Her2 Neu Positive

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Dr. Liawaty Ho Dr. Ho
4 doctors agreed:
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Chemotherapy hormone receptor positive node breast cancer?

Dr. Liawaty Ho Dr. Ho
4 doctors agreed:
Chemotherapy hormone receptor positive node breast cancer?

D/W oncologist: Treatment will depend not only the stage but also the biology of the cancer- whether it is estrogen positive, her2neu positive, whether it is lymph node positive or not. Also depends on your preference and overall health condition. Different test like oncotype dx, mammaprint can give you more info-re- recurrence risk of cancer and will be helpful in choosing the right therapy for you.D/w your md. ...Read more

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Dr. Barry Rosen
4,435 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Anyone have stage 1 breast cancer with her2/neu positive er/pr negative?

Anyone have stage 1 breast cancer with her2/neu positive er/pr negative?

Yes: Breast cancers can be highly variable from one person to the next. Cell types and dna evaluations can be performed now that can help direct the best treatments for each person. Her-2 breast cancers may be best treated with specialized chemotherapy agent heceptin. ...Read more

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What is estrogen receptor positive breast cancer?

What is estrogen receptor positive breast cancer?

One with receptors.: These are tumors with estrogen receptors on them. This makes them susceptable to some chemotherapeutic agents, like tamoxifen. ...Read more

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My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?

My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?

No its medullary: a quote from Lancethttp://www.ncbi.nlm.nih.gov/pubmed/9167459: "The occurrence of invasive lobular carcinoma and invasive ductal carcinoma was not significantly different between carriers of BRCA1 or BRCA2 mutations and controls. Medullary or atypical medullary carcinoma was, however, found more often in BRCA1 (13%, p ...Read more

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Stage 3 breast cancer her2 positive how many herceptin (trastuzumab) cycle she must undergo?

Stage 3 breast cancer her2 positive how many herceptin (trastuzumab) cycle she must undergo?

Up to 1 year's worth: Herceptin (trastuzumab) can be given together with initial chemotherapy for the first 4-6 months then subsequently by itself for a total of 1 year. If chemotherapy was given first without Herceptin (trastuzumab) then Herceptin (trastuzumab) can be given for a full year by itself. The usual cycle runs every 3 weeks (17-18 cycles in one full year). ...Read more

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O had surgery for positive breast cancer. Is sentinel lymph node biopsy accurate for breast cancer surgery. Node was negative.

O had surgery for positive breast cancer. Is sentinel lymph node biopsy accurate for breast cancer surgery. Node was negative.

Yes they are: by now sentinel lymph node are the standard of care for breast cancer surgery and staging, and yes they are very accurate. node is negative is a very good news that will make the cancer early stage and hopefully cureable ...Read more

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Is chemotherapy required for stage 1A IDC breast cancer, tumor size 1.1 cm, ER & PR positive, HER2 negative, nuclear grade 1. Patient is 42 years old.

Is chemotherapy required for stage 1A IDC breast cancer, tumor size 1.1 cm, ER & PR positive, HER2 negative, nuclear grade 1. Patient is 42 years old.

Borderline call!: Your breast tumor is quite small, so it has >90% odds that it can be safely treated with surgery, without any chemotherapy required. You may ask your doctor for treating you with tamoxifen which is a antihormone type of medication, commonly used as the treatment for tumors that are ER positive. Good luck ...Read more

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If report reads: estrogen reactor weakly positive, progesterone negative, her2 negative &invasive ductal carcinoma. Is this a triple negative cancer?

If report reads: estrogen reactor weakly positive, progesterone negative, her2 negative &invasive ductal carcinoma. Is this a triple negative cancer?

Even a weak ER+: Makes this better prognosis, and depending on other factors (oncotype, size, nodes) invite the use of tamoxifen or Arimidex (anastrozole) or Letrozole after chemo. All triple negative is not the same. Best wishes. ...Read more

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Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Get Oncotype: In order to answer this question, more details are needed (size of tumor, lymph node involvement, etc). A test that will help to decide if you need chemotherapy or not is the oncotype dx. I highly recommend you speak with your oncologist and even consider a 2nd opinion. ...Read more

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32 YO, triple positive, grade 3, stage 1B breast cancer. TCH chemotherphy, had dbl mastectomy. What is survival rate?

32 YO, triple positive, grade 3, stage 1B breast cancer. TCH chemotherphy, had dbl mastectomy.  What is survival rate?

Need Clarification!: Are you sure your breast cancer was triple positive(or was it triple Negative)??? TCH is commonly used chemotherapy for triple negative, so please double check and let us know. Then we can give you survival figures. In general, small tumors(Stage 1 and stage 2) have very good survival rate and high cure rates. ...Read more

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What is the her2- positive breast cancer survival rate?

What is the her2- positive breast cancer survival rate?

Very high!: The five year survival rate for all breast cancer is over 90%. Her2+ cancers used to have the worst prognosis, but Herceptin (trastuzumab) changed that. Now they have a very good prognosis if they are caught at an early stage (stage 1 or 2). The stage really determines the prognosis, so without that information i can't give you a number. But I am happy for my patients with a her2+ cancer-- many treatments! ...Read more

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Is there a benefit to chemotherapy in hormone receptor positive, node positive postmenopausal breast cancer?

Is there a benefit to chemotherapy in hormone receptor positive, node positive postmenopausal breast cancer?

Often: There is increasing data based on the oncotype DX test in women with 1-3 positive notes that shows that some women will not get much benefit from chemo and some will get a great deal. It can be useful in cases where a woman is reluctant to take chemo. This is done on tissue that has been already removed. Most oncologists believe that women who have multiple positive nodes should get chemotherapy. ...Read more

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43 yo female 1.5 CM stage 1 breast ca, idc, er/pr+, node neg, lumpectomy with neg margins, no lvi, oncotype score 11. Chemo+rt+tamoxifen or no chemo?

43 yo female 1.5 CM stage 1 breast ca, idc, er/pr+, node neg, lumpectomy with neg margins, no lvi, oncotype score 11. Chemo+rt+tamoxifen or no chemo?

ARR - non-binary: Using adjvuant online! and making some assumptions for missing data: there is a 25% risk of relapse, tamoxifen absolute risk reduction (arr) is 9%, chemo arr 14%, combo (chemo+tam) is 18% arr. Combo-chemo is 18-14% is 4% absolute benefit from chemo. This low benefit is confirmed with oncotype DX recurrence score (low risk). So, the decision is non-binary, but rather about the arr benefit. ...Read more

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Treatment for her2 breast cancer?

Treatment for her2 breast cancer?

Herceptin (trastuzumab): The local treatment option (breast conservation versus mastectomy) are the same. The diff comes with systemic therapy. Her2+ cancers are more aggressive but this is counteracted by the biological (antibody) herceptin (trastuzumab). This is generally given with chemo. Since this is the case, it may often given before surgery (neoadj) to gain additional prognostic info and shrink the primary. ...Read more

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My mom has 3rd breast cancer recurrence but is brca1/2 negative. Am I high risk for breast cancer?

My mom has 3rd breast cancer recurrence but is brca1/2 negative. Am I high risk for breast cancer?

Yes you are: Breast cancer does have some hereditary tendency. So sisters and daughters of a breat cancer patients have a small increase in their risk for developing breast cancer. yet >90% of the time there is no relationship to such an occurrence. So you need to be vigilant but not worry much about it. Just learn about breast self examination and do annual mammograms beginning at age 40 yr. ...Read more

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Tell me the metastatic triple negative breast cancer survival rates?

Tell me the metastatic triple negative breast cancer survival rates?

Depends: Survival rates depend on multiple factors; age, response to treatment, stage of disease, your overall health. This is a conversation best had with your medical oncologist. ...Read more

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Family history breast cancer, even Mom. 2 cousins got breast cancer but tested negative BRAC1/2. Should I get test. Cancer on both sides family?

Family history breast cancer, even Mom. 2 cousins got breast cancer but tested negative BRAC1/2. Should I get test. Cancer on both sides family?

Genetic counselor: You and your mom should meet with a genetic counselor. They will sit with you and discuss the family history and draw out a family tree to determine where the risk may be. Check with your local breast cancer center for a referral. ...Read more

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Does pr-negative breast cancer respond to tamoxifen?

Does pr-negative breast cancer respond to tamoxifen?

It depends.: Tamoxifen is used to treat hormone-sensitive breast cancer. This is determined by checking for estrogen receptors (er) and Progesterone receptors (pr) on the cancer. If the cancer is er+ and pr- (or vice-versa), it should respond to tamoxifen. However, if the cancer is er- and pr-, tamoxifen is not effective. ...Read more

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Survival rate for triple neg receptors for early stage breast cancer after chemo treatment? No lymph nodes involve, stage 1b, grade 2, mastec done

Survival rate for triple neg receptors for early stage breast cancer after chemo treatment?  No lymph nodes involve, stage 1b, grade 2, mastec done

Excellent: According to adjuvant online (www.Adjuvantonline.Com), you have about an 82% 10 yr survival rate based on your specific information provided. This is only an estimate since there are details I do not have such as type of chemotherapy being used. For triple negative breast cancer, these survival rates are quite excellent. ...Read more

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My mom had lobular breast cancer at 54 and her paternal cousin had breast cancer at 48. Everyone is brca negative. Is this likely hereditary?

My mom had lobular breast cancer at 54 and her paternal cousin had breast cancer at 48. Everyone is brca negative. Is this likely hereditary?

Hard to tell...: ...without more info. BRCA 1 and 2 are not the only genes known to increase the risk for cancer and there are probably others we do not know anything about. Someone in the family (preferably your mom or her cousin) should visit a genetic counselor (if they have not yet done so) to see what other genes need to be tested if necessary and what else they can do to reduce their risk. ...Read more

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Anyone have stage 1 breast cancer with her2/neu positive er/pr negative?

Yes: Breast cancers can be highly variable from one person to the next. Cell types and dna evaluations can be performed now that can help direct the best treatments for each person. Her-2 breast cancers may be best treated with specialized chemotherapy agent heceptin. ...Read more

See 1 more doctor answer
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What does it mean if I tested HER2-positive for breast cancer?

What does it mean if I tested HER2-positive for breast cancer?

Aggressive: HER2 is a gene present in many cells that sends control signals causing the cells to grow, divide, and make repairs. A normal breast cell has 2 copies of the HER2 gene. Certain breast cancers start when a cell has more than 2 copies of that gene, and start over-producing the HER2 protein. The involved tumor cells grow and divide more quickly. These tumor cells are sensitive to Herceptin (trastuzumab). ...Read more

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Is her2 better if negative or positive in regards to breast cancer?

Is her2 better if negative or positive in regards to breast cancer?

Better.: HER2 receptor testing (along with estrogen and progesterone receptor testing) is done on breast cancer tissue to help guide the oncologist for endocrine chemotherapy. It's better if tissues are positive in each case as this increases the treatment choices. If all three are negative (triple negative breast cancer), the prognosis for cure is diminished. ...Read more

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Is her2 positive or her2 negative better when dealing with breast cancer?

Time will tell: Her 2 over expressed breast cancer is considered to be more aggressive and have a higher risk of recurring. That being said, there are many more targeted agents which make this type of breast cancer more treatable and curable. ...Read more

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What is the her2- positive breast cancer survival rate?

Very high!: The five year survival rate for all breast cancer is over 90%. Her2+ cancers used to have the worst prognosis, but Herceptin (trastuzumab) changed that. Now they have a very good prognosis if they are caught at an early stage (stage 1 or 2). The stage really determines the prognosis, so without that information i can't give you a number. But I am happy for my patients with a her2+ cancer-- many treatments! ...Read more

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What do ER and her2 positive mean in relation to breast cancer?

What do ER and her2 positive mean in relation to breast cancer?

Receptor Status: The er positive refers to the receptor status of the breast cancer. This means that the tumor has receptors to estrogen and that anti-estrogen therapy can be used to slow the growth of the tumor. Her2 is a another receptor that is a target of a chemotherapeutic agent called herceptin (trastuzumab). ...Read more

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What are the symptoms of early stage Her2 positive breast cancer?

What are the symptoms of early stage Her2 positive breast cancer?

Lump : Her2 cancers may tend to grow and spread faster than Her2 negative cancers. There are also specific medicines that can be used with Her2 positive cancers. However, there are really no symptoms specific for a Her2 cancer. Like all early stage cancers, there may be no symptoms(and the cancer is detected on mammogram or ultrasound), or there may be a palpable mass. ...Read more

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Which is easier to cure a breast cancer who is a pr/er positive and her2 negative or er/pr negative and her2 positive? Who has longer prognosis?

Which is easier to cure a breast cancer who is a pr/er positive and her2 negative or er/pr negative and her2 positive? Who has longer prognosis?

ER positive: In general, er+ has better prognostic features. However, the entire picture has to be evaluated (tumor size, lymph node involvement, distant spread) in order to determine prognosis for you. A big factor is individual biology. Tumors are different in different people, different ages and even ethnicities. Focus on following your prescribed treatment regimen and thinking positive. ...Read more

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I am 71. At age 62 I had her2 positive and ER positive breast cancer with 6 positive nodes out of 16, . What are the odds of return of breast cancer?

I am 71.  At age 62 I had her2 positive and ER positive breast cancer with 6 positive nodes out of 16, .  What are the odds of return of breast cancer?

Good odds: You are in pretty good territory 9 years after the diagnosis and treatment of breast cancer. You should have been on antiestrogen therapy for a minimum of 5 years, and probably for a full 10 years. Although breast cancer is known to occur more than 20 years after it is first diagnosed, this is unusual. ...Read more

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Her2-positive breast cancer stage 1 level 3 and 70 yrs old - how much longer can somebody expect to live?

Her2-positive breast cancer stage 1 level 3 and 70 yrs old - how much longer can somebody expect to live?

A full lifetime: Stage 1 cancer is curable with appropriate treatment. With surgery to remove the tumor, and appropriate chemotherapy including herceptin, (trastuzumab) the chance of cure is very high. In someone age 70, the doses of chemo drugs might need to be reduced, but Herceptin (trastuzumab) is not chemo. Older people do well on it! it is very unlikely she will die from breast cancer if she gets good treatment now. ...Read more

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Im a breast cancer positive, stage 1 with her2 positive, is completly necesary the chemotherapy in my case?

Im a breast cancer positive, stage 1 with her2 positive, is completly necesary the chemotherapy in my case?

Breast CA: It really depends on your risk factors and tumor characteristics. You should have a through consultation with a medical oncologist to determine the best course. ...Read more

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Stage 3 breast cancer her2 positive how many herceptin (trastuzumab) cycle she must undergo?

Up to 1 year's worth: Herceptin (trastuzumab) can be given together with initial chemotherapy for the first 4-6 months then subsequently by itself for a total of 1 year. If chemotherapy was given first without Herceptin (trastuzumab) then Herceptin (trastuzumab) can be given for a full year by itself. The usual cycle runs every 3 weeks (17-18 cycles in one full year). ...Read more

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Is chemotherapy required for stage 1A IDC breast cancer, tumor size 1.1 cm, ER & PR positive, HER2 negative, nuclear grade 1. Patient is 42 years old.

Borderline call!: Your breast tumor is quite small, so it has >90% odds that it can be safely treated with surgery, without any chemotherapy required. You may ask your doctor for treating you with tamoxifen which is a antihormone type of medication, commonly used as the treatment for tumors that are ER positive. Good luck ...Read more

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I am a 55 year old, post menopausal woman. My ER and pr are positive and her2 is negative. I have been diagnosed with stage t1n0m0 breast cancer, my tumor being 1.2 CM big. Can chemo be avoided?

I am a 55 year old, post menopausal woman. My ER and pr are positive and her2 is negative. I have been diagnosed with stage t1n0m0 breast cancer, my tumor being 1.2 CM big. Can chemo be avoided?

Need Oncotype-Dx: While your prognosis is excellent, we know that some women with your stage may benefit from traditional chemotherapy in addition to an aromatase inhibitor. Nowadays, we are moving towards molecular staging over anatomic staging; oncotype-dx is a multi-gene assay that can provide information regarding your probability of recurrence; if it is high, traditional chemo will be recommended. ...Read more

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What are the odds of having stage 2B invasive ductal carcinoma her2 positive breast cancer and papillary thyroid cancer at age 40?

What are the odds of having stage 2B invasive ductal carcinoma her2 positive breast cancer and papillary thyroid cancer at age 40?

Odds are low.: But it is still possible to have both. Risk of having papillary thyroid before forty is about 13/100,000. Risk of having breast Ca is about 11/100,000. The overlap of the two independent events is slightly less than 1 in a million. ...Read more

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What is the function of HER2/neu and how is it related to breast cancer?

What is the function of HER2/neu and how is it related to breast cancer?

Growth signal: Her2 is a receptor on the surface of some breast cancers. It is like a light switch that tells the cancer to grow. Breast cancer cells that have many Her2 receptors have the light switch always turned on, telling the cells to grow. Fortunately, newer drugs block the receptor, turning off the growth switch and making these cancers very treatable. ...Read more

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Is the present of HER2 a good or bad prognosis in breast cancer?

Is the present of HER2 a good or bad prognosis in breast cancer?

Both: These tumors are on average more aggressive than their HER-negative counterparts, but also respond to herceptin (trastuzumab) which is very effective. ...Read more

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Treatment for her2 breast cancer?

Herceptin (trastuzumab): The local treatment option (breast conservation versus mastectomy) are the same. The diff comes with systemic therapy. Her2+ cancers are more aggressive but this is counteracted by the biological (antibody) herceptin (trastuzumab). This is generally given with chemo. Since this is the case, it may often given before surgery (neoadj) to gain additional prognostic info and shrink the primary. ...Read more

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Tretment of acase of breast cancer .With pulmonary hypertention. T2n0m0, pr -ve er- ve , her2/neu+3?

Tretment of acase of breast cancer .With pulmonary hypertention. T2n0m0, pr -ve er-  ve , her2/neu+3?

Treatment depends: This is a stage 1 breast cancer which can be treated with long term survival but treatment may include targeted chemotherapy that does have some risk of affecting the heart so really depends on severity of pulmonary HTN and ascertaining your ability to undergo treatment, which may include surgery, chemo, and radiation. ...Read more

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I'm er+ pr- and her2+, but been told I have triple negative breast cancer. What is that?

I'm er+ pr- and her2+, but been told I have triple negative breast cancer. What is that?

Mixed info: Triple negative refers to the phenotype that is er neg. Pr neg. And her2 neg. These are usually treated with the addition of chemo often upfront to determine which are chemo sensitive (often very much so) and which are resistant (poorer prognosis). Talk with your doctor and perhaps ask to see your path report if still unsure. ...Read more

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Dr. Mark Hoepfner
1,070 doctors shared insights

Breast Carcinoma (Definition)

Most breast cancers are carcinomas. This is a type of breast cancer. These cancers start in the cells that line organs and tissues. In fact, breast cancers are often a type of carcinoma called adenocarcinoma, which starts in cells that make glands (glandular tissue). Breast adenocarcinomas start in the ducts (the milk ducts) or ...Read more


Dr. Barry Rosen
1,397 doctors shared insights

Breast Cancer (Definition)

A condition in which cells lining the inside of the breast grow ...Read more