Top 20 Doctor insights on: Breast cancer genes brca1 and brca2

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How are brca1 and brca2 related to the development of breast cancer?

How are brca1 and brca2 related to the development of breast cancer?

Very high risk: Patients who are brca positive have a very high risk of developing breast cancer. They can have an 80-90% risk (over lifetime) of developing 1 breast cancer, 50-65% chance of developing a 2nd breast cancer and a 40-50% risk of developing ovarian cancer.
Please see this link for more details:
http://www. Cancer. Gov/cancertopics/factsheet/risk/brca. ...Read more

Dr. Barry Rosen
4,342 Doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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I was told that if someone was treated for breast cancer 20yrs ago with tamoxifen, that they did not carry the BRCA1 & BRCA2 mutations? Is this true?

I was told that if someone was treated for breast cancer 20yrs ago with tamoxifen, that they did not carry the BRCA1 & BRCA2 mutations? Is this true?

BRCA test was not av: BRCA test is not often done, unless there is strong family history of breast Cancer in multiple members. This test was not available 20 years back, so it would not have been done. But it is not to be done except in selected cases where we suspect it may be abnormal. ...Read more

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About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?

About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?

50:50 inheritance: Any child of a brca carrier has a 50:50 chance of inheriting that mutation. If they have inherited the mutation, they have a 50-80% chance of developing breast cancer, and an increeased risk of several other cancers. For more information, check this link: http://www. Cancer. Gov/cancertopics/factsheet/risk/brca. ...Read more

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What's cause and effect of brca1 gene on breast cancer?

What's cause and effect of brca1 gene on breast cancer?

Genetic mutation: Genetic mutation in long arm of chromosome 17 in brca 1, in 13 brca 2, instead of normal protective proteins which control abnormal growth of cell, repair broken down dna, maintain genetic stability, the abnormal proteins fail to protect, and responsible for 40% inherited breast cancers, 80% of breast & ovarian cancers. ...Read more

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What kind of mutation is present in the brca1 gene in the breast cancer families?

What kind of mutation is present in the brca1 gene in the breast cancer families?

Loss of function: Brca 1 and 2 genes encode proteins than normally repair our dna. When the genes are mutated, the protein they normally make does not work correctly, leading to loss of the ability to fix other dna mutaions, and development of tumors. ...Read more

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What is the life expectancy of a 54yr woman with Stage 4 Breast cancer, metastasized to bones, brain and spinal fluid? BRCA2 positive

What is the life expectancy of a 54yr woman with Stage 4 Breast cancer, metastasized to bones, brain and spinal fluid? BRCA2 positive

Mets of Breast cance: It depends on treatment so far...This is not a good prognosis. It is all about managing quality of life and options. No one knows of course, life expectancy but in my opinion quality of life is MOST important ...Read more

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My mom has 3rd breast cancer recurrence but is brca1/2 negative. Am I high risk for breast cancer?

My mom has 3rd breast cancer recurrence but is brca1/2 negative. Am I high risk for breast cancer?

Yes you are: Breast cancer does have some hereditary tendency. So sisters and daughters of a breat cancer patients have a small increase in their risk for developing breast cancer. Yet >90% of the time there is no relationship to such an occurrence. So you need to be vigilant but not worry much about it. Just learn about breast self examination and do annual mammograms beginning at age 40 yr. ...Read more

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36 year-old woman whose mother was diagnosed with breast cancer at age 34 and a PALB2 mutation wonders if mastectomy is needed to lower her risk.....?

36 year-old woman whose mother was diagnosed with breast cancer at age 34 and a PALB2 mutation wonders if mastectomy is needed to lower her risk.....?

No!: Although the PALB2 mutation increases risk, preventive mastectomy is not recommended. There are other ways to decrease your risk including taking raloxifene or tamoxifen. See a medical oncologist to discuss this (and a genetic counselor!) ...Read more

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Can all breast cancer patients carry the brca genes?

Can all breast cancer patients carry the brca genes?

No!: Many patients with breast cancer have no genetic predisposition or risk for breast cancer.

However, there are several genetic markers which increase the risk of developing breast cancer over a person's lifetime. ...Read more

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What are the statistics of the brca/breast cancer gene?

Low incidence: Approximately 1 in 40 ashkenazi jewish women have a brca mutation. It also is seen in other isolated populations. A brca1 mutation can be inherited from a mother or father and is associated with up to a 80% lifetime risk of breast cancer and a 40 % risk of ovarian cancer
options include increased surveillance chemo prevention or risk reduction surgery. ...Read more

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I was wondering is breast cancer a gene or chromosomal disorder?

I was wondering is breast cancer a gene or chromosomal disorder?

Yes and No: I think you are really asking if breast cancer is hereditary, meaning is it past from a parent it is possible to inherit a predisposition to breast cancer. There are a few genes known to cause this like brca 1 ; 2 and tests can be done for them. On the other hand all breast cancers have genetic abnormalities. These changes however were not inherited but happened in the patient. ...Read more

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What do you suggest if my mum died of breast cancer, will my sister have the gene?

What do you suggest if my mum died of breast cancer, will my sister have the gene?

Not necessarily: Most breast cancers are not caused by an inherited mutation in a gene like BRCA ("the gene"). You should talk to your family doc or GYN and see if they recommend a consultation with a specialist in risk assessment and cancer genetics. Best to you and be safe. ...Read more

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I am about to get tested for the breast cancer gene. If positive should I get a mastectomy?

I am about to get tested for the breast cancer gene. If positive should I get a mastectomy?

That is not a: Decision that should be made by an on-line doctor who does not know you or your personal history. That is a very individual decision that should be made carefully with full information about risks with and without surgery. ...Read more

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If two members of my immediate family developed breast cancer, should I get tested for the brca gene?

If two members of my immediate family developed breast cancer, should I get tested for the brca gene?

Possibly: It's always better to test the family members who have breast cancer if possible. If they are first degree relatives (mother, daughter or sister) and one was under age 50 at diagnosis, you might meet criteria for brca testing. It's best to meet with a genetic counselor who can help guide you and your family so the correct people are tested. There are non-brca mutations as well. ...Read more

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Are there particular genes involved in breast cancer?

Are there particular genes involved in breast cancer?

Yes: There are 2 gene mutations, brca1 and brca2, which have been discovered and which substantially increase one's risk of getting breast cancer. Since breast cancer tends to run in families, there are probably many other gene mutations which haven't been discovered yet. But most women who get breast cancer do not have a family history, so it is likely that there are other factors besides genes. ...Read more

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What happens during the breast cancer gene test?

What happens during the breast cancer gene test?

Blood test: It is a blood test to look for the rare brca gene to see if there are increased ridks of breast or ovarian cancer. Is only found in 5% of women for increased breast cancer risk. See: http://www. Mayoclinic. Com/health/brca-gene-test/my00322. ...Read more

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What's your opinion on the "breast cancer gene test"?

What's your opinion on the "breast cancer gene test"?

BRAC Analysis: As many as 10-15% of breast cancers in the us are believed to be hereditary. These are linked to mutations of a particular group of genes called the brca genes. There is a simple blood test to check to see if someone has a brca mutation. I advise my interested patients to see a genetic counselor to fully understand the ramifications of this test before having it done. ...Read more

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Gene expression profiling predicts clinical outcome of breast cancer?

Gene expression profiling predicts clinical outcome of breast cancer?

We're Getting There: In the past, we used anatomic staging alone (tumor size, lymph node involvement) to guide rx. Gene profiling allows us a completely separate measure of prognosis, and, more importantly, can predict who may or may not benefit from different chemotherapy agents. In the future, we will hopefully be able to tailor our rx to the specific cancer being treated: the elusive personalized medicine. ...Read more

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Describe microrna gene expression deregulation in human breast cancer?

Describe microrna gene expression deregulation in human breast cancer?

Can't do in 400: The study of micro-rnas is cutting-edge and extremely arcane and you need to go directly to pubmed or one of the other big ways to access the scientific data. If someone is offering a breast cancer treatment to re-regulate your micro-rna's, call your district attorney. Glad you have an inquiring mind and I wish you luck with your project. ...Read more

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What is the hereditary breast cancer gene?

What is the hereditary breast cancer gene?

Mutations to: Brca1 and brca2 is associated with the most common inheritable breast cancer. ...Read more

Dr. Barry Rosen
1,378 Doctors shared insights

Breast Cancer (Definition)

Occurs when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. Often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more


Dr. Mark Hoepfner
1,061 Doctors shared insights

Breast Carcinoma (Definition)

Most breast cancers are carcinomas. This is a type of breast cancer. These cancers start in the cells that line organs and tissues. In fact, breast cancers are often a type of carcinoma called adenocarcinoma, which starts in cells that make glands (glandular tissue). Breast adenocarcinomas start in the ducts (the milk ducts) or ...Read more