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Doctor insights on: Breast Cancer Gene Expression

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Gene expression profiling predicts clinical outcome of breast cancer?

Gene expression profiling predicts clinical outcome of breast cancer?

We're Getting There: In the past, we used anatomic staging alone (tumor size, lymph node involvement) to guide rx. Gene profiling allows us a completely separate measure of prognosis, and, more importantly, can predict who may or may not benefit from different chemotherapy agents. In the future, we will hopefully be able to tailor our rx to the specific cancer being treated: the elusive personalized medicine. ...Read more

Dr. Barry Rosen
4,316 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Describe microrna gene expression deregulation in human breast cancer?

Describe microrna gene expression deregulation in human breast cancer?

Can't do in 400: The study of micro-rnas is cutting-edge and extremely arcane and you need to go directly to pubmed or one of the other big ways to access the scientific data. If someone is offering a breast cancer treatment to re-regulate your micro-rna's, call your district attorney. Glad you have an inquiring mind and i wish you luck with your project. ...Read more

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Diagnosing Breast Lumps (Checklist)

Do a breast self exam after your period ends
monthly
Check daily in shower after soaping up
daily
Learn the architecture of your breasts by repetition
once
Observe skin around nipples
once
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Gene expression profiling predicts clinical outcome of breast cancer?

We're Getting There: In the past, we used anatomic staging alone (tumor size, lymph node involvement) to guide rx. Gene profiling allows us a completely separate measure of prognosis, and, more importantly, can predict who may or may not benefit from different chemotherapy agents. In the future, we will hopefully be able to tailor our rx to the specific cancer being treated: the elusive personalized medicine. ...Read more

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Describe microrna gene expression deregulation in human breast cancer?

Can't do in 400: The study of micro-rnas is cutting-edge and extremely arcane and you need to go directly to pubmed or one of the other big ways to access the scientific data. If someone is offering a breast cancer treatment to re-regulate your micro-rna's, call your district attorney. Glad you have an inquiring mind and i wish you luck with your project. ...Read more

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Managing Pain from Cancer (Checklist)

Ask oncologist to refer you to cancer pain specialist
Once
Ask pain specialist about both interventional and medication options
Once
If pancreatic cancer, ask about a celiac plexus block
Once
If neuropathy, request trial of ketamine-based topical creams
Once
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Is breast cancer caused by a mutation in the gene or by a problem with the gene expression?

Is breast cancer caused by a mutation in the gene or by a problem with the gene expression?

Gene mutation: If not a genetically inherited , environmental conditions initiate the induction of the breast lesion. The most common mutation occurs with the long terminal repeat of the MMTV virus enters the Wnt-1 gene. This produces an over expression of B-catenin which results in transformation. EBV infection probably needed for FGARAT production that acts to overexpress telomerase inducing immortality. ...Read more

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What happens during the breast cancer gene test?

What happens during the breast cancer gene test?

Blood test: It is a blood test to look for the rare brca gene to see if there are increased ridks of breast or ovarian cancer. Is only found in 5% of women for increased breast cancer risk. See: http://www.Mayoclinic.Com/health/brca-gene-test/my00322. ...Read more

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Living with Skin Cancer (Checklist)

Avoid sun exposure between 10 am and 2 pm
daily
Apply sunscreen
2x day
Wear a hat outdoors on sunny days
daily
See dermatologist for check ups
2x year
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What's your opinion on the "breast cancer gene test"?

What's your opinion on the "breast cancer gene test"?

BRAC Analysis: As many as 10-15% of breast cancers in the us are believed to be hereditary. These are linked to mutations of a particular group of genes called the brca genes. There is a simple blood test to check to see if someone has a brca mutation. I advise my interested patients to see a genetic counselor to fully understand the ramifications of this test before having it done. ...Read more

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What is the hereditary breast cancer gene?

What is the hereditary breast cancer gene?

Mutations to: Brca1 and brca2 is associated with the most common inheritable breast cancer. ...Read more

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Hereditary breast cancer gene, what is it?

Hereditary breast cancer gene, what is it?

Wsh I had more space: BRCA 1 and 2 are important genes that have the purpose of repairing damaged DNA and destroying the one that can't be repaired, amongst other things. When they get mutated (or changed) in specific places, they quit working so the damaged DNA is left in there, resulting in the development of cancer. ...Read more

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Can all breast cancer patients carry the brca genes?

Can all breast cancer patients carry the brca genes?

No!: Many patients with breast cancer have no genetic predisposition or risk for breast cancer. However, there are several genetic markers which increase the risk of developing breast cancer over a person's lifetime. ...Read more

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What are the statistics of the brca/breast cancer gene?

Low incidence: Approximately 1 in 40 ashkenazi jewish women have a brca mutation. It also is seen in other isolated populations. A brca1 mutation can be inherited from a mother or father and is associated with up to a 80% lifetime risk of breast cancer and a 40 % risk of ovarian cancer options include increased surveillance chemo prevention or risk reduction surgery. ...Read more

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I'm doing a project and need a gene sequence for Breast cancer in chromosome 1.

I'm doing a project and need a gene sequence for Breast cancer in chromosome 1.

Gene sequencing cos: There are a number of gene sequencing companies that may be able to help you. EG, 23andme, and DNA4life ...Read more

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Do you think I should get mammograms earlier or be tested for the breast cancer gene?

Do you think I should get mammograms earlier or be tested for the breast cancer gene?

If you are: 45, you should already be getting mammograms according to ACS guidelines. If you have a strong family history, genetic testing might be appropriate, but talk to your doctor about it. ...Read more

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What can my girlfriend do if she is found positive for the breast cancer gene?

What can my girlfriend do if she is found positive for the breast cancer gene?

Difficult: To answer here. Review with her family doctor for referrals. See a medical geneticist. If truly concerned see a medical oncologist to see if there are medications (anti-estrogen hormones) to try. If very concerned or very high risk, sometimes mastectomy and plastic surgery reconstruction is considered. ...Read more

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I was wondering is breast cancer a gene or chromosomal disorder?

I was wondering is breast cancer a gene or chromosomal disorder?

Yes and No: I think you are really asking if breast cancer is hereditary, meaning is it past from a parent it is possible to inherit a predisposition to breast cancer. There are a few genes known to cause this like brca 1 ; 2 and tests can be done for them. On the other hand all breast cancers have genetic abnormalities. These changes however were not inherited but happened in the patient. ...Read more

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What do you suggest if my mum died of breast cancer, will my sister have the gene?

What do you suggest if my mum died of breast cancer, will my sister have the gene?

Not necessarily: Most breast cancers are not caused by an inherited mutation in a gene like BRCA ("the gene"). You should talk to your family doc or GYN and see if they recommend a consultation with a specialist in risk assessment and cancer genetics. Best to you and be safe. ...Read more

Dr. Barry Rosen
1,365 doctors shared insights

Breast Cancer (Definition)

Occurs when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. Often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more


Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more