Doctor insights on:
Breast Cancer Brca Gene
Breast Cancer (Female) (Definition)
Breast cancer results when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. The growth occurs initially inside the ducts but eventually breaks outside into the breast tissue and ultimately spreads both to the lymph nodes in the armpit and via the bloodstream to other parts of the body. Because of the promoting affect of estrogen almost all breast cancer occurs in women and is a rarity in men. The unregulated growth is due to both inherited and acquired genetic defects. It is the most common malignancy in women but it often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast on an annual basis. ...Read more
Low incidence: Approximately 1 in 40 ashkenazi jewish women have a brca mutation. It also is seen in other isolated populations. A brca1 mutation can be inherited from a mother or father and is associated with up to a 80% lifetime risk of breast cancer and a 40 % risk of ovarian cancer options include increased surveillance chemo prevention or risk reduction surgery. ...Read moreSee 2 more doctor answers
If two members of my immediate family developed breast cancer, should I get tested for the brca gene?
Possibly: It's always better to test the family members who have breast cancer if possible. If they are first degree relatives (mother, daughter or sister) and one was under age 50 at diagnosis, you might meet criteria for brca testing. It's best to meet with a genetic counselor who can help guide you and your family so the correct people are tested. There are non-brca mutations as well. ...Read moreSee 2 more doctor answers
When I have my daughter tested for brca gene? My husband's sister was diagnosed with stage 3 breast cancer. no other history of b.C. In our families.
Not now: If your sister in law had cancer before age 45 or had a triple negative cancer before age 60, she fits nccn criteria for brca testing even without family history. She needs to test first and if positive, your husband should test and if he is positive, then you test your girl. Cancer can jump an individual but the gene cannot. Hope all goes well with all in the family. ...Read moreSee 2 more doctor answers
My mother had breast cancer at 54 and her cousin was diagnosed at 45. Is this likely caused by the brca gene? My insurance won't pay for it.
If negative for brca gene, yet father had prostate cancer, is his daughter still at risk for breast cancer? I heard they were linked.
Not elevated risk: In families who DO have a BRCA mutation, the breast and prostate cancers can be linked. However both are very common cancers, so they can be seen within families even if BRCA negative. The average lifetime risk of breast cancer for any given woman is 12.5%. You can do a search for the Gail Risk Model to get a little better idea of your own personal risk. ...Read moreSee 1 more doctor answer
My mother was diagnosed with breast cancer at 54, grandmother had pancreatic cancer at 70 and great aunt had colon cancer at 65. No one else has cancer in my large family. Could I have the brca gene?
Very Low Risk: The risk of having a brca mutation can be estimated at: http://www.Myriadpro.Com/brca-risk-calculator/calc.Html. A woman with ashkenazi jewish heritage and this family history would have about an 8% chance of having a brca mutation. Without ashkenazi heritage the risk drops to 1.5%. The best way to know for sure would be to have your mother see a genetic counselor and consider having testing. ...Read moreSee 2 more doctor answers
About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?
50:50 inheritance: Any child of a brca carrier has a 50:50 chance of inheriting that mutation. If they have inherited the mutation, they have a 50-80% chance of developing breast cancer, and an increeased risk of several other cancers. For more information, check this link: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read moreSee 2 more doctor answers
How many relatives need to have had breastcancer before you should get genetic testing for the BRCA genes? My mother contracted breast cancer, I am 40
See genetics: Most breast cancer is NOT due to an inherited risk, but rather occurs by chance. Family history that suggests an inherited risk, such as changes in the BRCA1 gene or BRCA2 gene, include multiple relatives with cancer over more than one generation and younger ages of onset. If you are concerned about an inherited risk, see a geneticist who can assess your family history. ...Read moreSee 2 more doctor answers
Mother had lobular breast cancer at 52-- post menopause.Negative for brca genes, atm, p53, cdh1, etc. Is there a strong likelihood i'll get it a well?
Possible: Various causes result in breast cancer in a family. If BRACA is neg then there is no genetic relationship to getting the Ca. Exposure to the MMTV virus probably results in 80% chance of having a tumor. Also recognized that endogenous sequences of virus can be passed and when proper reorganization of the sequences takes place, the viral genome can induce cancer. ...Read moreSee 1 more doctor answer
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more