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Doctor insights on: Brca1 And Brca2 Breast Cancer

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How are brca1 and brca2 related to the development of breast cancer?

How are brca1 and brca2 related to the development of breast cancer?

Very high risk: Patients who are brca positive have a very high risk of developing breast cancer. They can have an 80-90% risk (over lifetime) of developing 1 breast cancer, 50-65% chance of developing a 2nd breast cancer and a 40-50% risk of developing ovarian cancer. Please see this link for more details: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read more

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Dr. Barry Rosen
4,287 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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I was told that if someone was treated for breast cancer 20yrs ago with tamoxifen, that they did not carry the BRCA1 & BRCA2 mutations? Is this true?

I was told that if someone was treated for breast cancer 20yrs ago with tamoxifen, that they did not carry the BRCA1 & BRCA2 mutations? Is this true?

BRCA test was not av: BRCA test is not often done, unless there is strong family history of breast Cancer in multiple members. This test was not available 20 years back, so it would not have been done. But it is not to be done except in selected cases where we suspect it may be abnormal. ...Read more

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What is the life expectancy of a 54yr woman with Stage 4 Breast cancer, metastasized to bones, brain and spinal fluid? BRCA2 positive

What is the life expectancy of a 54yr woman with Stage 4 Breast cancer, metastasized to bones, brain and spinal fluid? BRCA2 positive

Mets of Breast cance: It depends on treatment so far...This is not a good prognosis..it is all about managing quality of life and options. No one knows of course, life expectancy but in my opinion quality of life is MOST important ...Read more

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About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?

About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?

50:50 inheritance: Any child of a brca carrier has a 50:50 chance of inheriting that mutation. If they have inherited the mutation, they have a 50-80% chance of developing breast cancer, and an increeased risk of several other cancers. For more information, check this link: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read more

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Whats cause and effect of brca1 gene on breast cancer?

Whats cause and effect of brca1 gene on breast cancer?

Genetic mutation: Genetic mutation in long arm of chromosome 17 in brca 1 , in 13 brca 2, instead of normal protective proteins which control abnormal growth of cell , repair broken down dna, maintain genetic stability, the abnormal proteins fail to protect, and responsible for 40% inherited breast cancers, 80% of breast & ovarian cancers. ...Read more

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My mom has 3rd breast cancer recurrence but is brca1/2 negative. Am I high risk for breast cancer?

My mom has 3rd breast cancer recurrence but is brca1/2 negative. Am I high risk for breast cancer?

Yes you are: Breast cancer does have some hereditary tendency. So sisters and daughters of a breat cancer patients have a small increase in their risk for developing breast cancer. yet >90% of the time there is no relationship to such an occurrence. So you need to be vigilant but not worry much about it. Just learn about breast self examination and do annual mammograms beginning at age 40 yr. ...Read more

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What kind of mutation is present in the brca1 gene in the breast cancer families?

What kind of mutation is present in the brca1 gene in the breast cancer families?

Loss of function: Brca 1 and 2 genes encode proteins than normally repair our dna. When the genes are mutated, the protein they normally make does not work correctly, leading to loss of the ability to fix other dna mutaions, and development of tumors. ...Read more

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36 year-old woman whose mother was diagnosed with breast cancer at age 34 and a PALB2 mutation wonders if mastectomy is needed to lower her risk.....?

36 year-old woman whose mother was diagnosed with breast cancer at age 34 and a PALB2 mutation wonders if mastectomy is needed to lower her risk.....?

You need testing: If your mother was a BRCA carrier then it is important that you get tested. Since you know that she has a PLAB2 mutation then your testing can even be more precise. If you are a carrier then see an experienced breast surgeon. They can calculate your lifetime risk as well as your 5 year risk to help you make your decisions regarding mastectomy and ovary removal ...Read more

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How common is breast cancer?

How common is breast cancer?

Pretty common : Estimated new cases and deaths from breast cancer in the United States in 2012: new cases: 226, 870 (female); 2, 190 (male) and 39, 510 (female); 410 (male) deaths. Lifetime risk is 1 to 8. Risk is higher with the increased of age. ...Read more

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Dr. Barry Rosen
1,356 doctors shared insights

Breast Cancer (Definition)

Occurs when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. Often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more


Brca2 Gene (Definition)

This is a normal gene that makes a protein for basic cell functions. It was the second gene discovered that is often mutated in people at extra risk for breast cancer, and depending on the mutation these people often have increased risk of ovarian cancer as well. A person with a family history may be tested for the mutation and make ...Read more