Doctor insights on:
Brca Test Results
34yr old sister had a brca test done. Her results came back as positive for one copy of c.6937+594t> g mutation in brca 2 gene. What does this mean?
? deleterious, now U: The testing report should specify if this is a "deleterious" mutation. If it is, then it is present throughout all her breast tissue increasing her risk of a second/subsequent breast cancer. It also confers a significant risk of ovarian cancer. As a 1st degree relative, you would have a 50% chance of carrying the same mutation and should be tested for this specific mutation. ...Read more
Mutation=cancer risk: People with mutations in the brca1 or brca2 gene are at higher risk of developing certain cancers. With a mutation, the lifetime risk of breast cancer is 41 to 90%, and ovarian cancer is 8 to 62%. Pancreatic and prostate cancer are more common as well. If you are a woman and test positive, you will have to consider having your ovaries and breasts removed. Genetic counseling is key! ...Read moreSee 1 more doctor answer
No: It's not the test that's the big deal, it's what one does with the information. Understanding what a positive and negative test means and what the decision options based on each are something that should be discussed and planned for before testing is sent. Without knowing family genetic status a neg. Test may not mean much. Thus, testing should start with an affected indiv. 1st if possible. ...Read moreSee 5 more doctor answers
Risk reduction: The "best" option is a personal choice. Options to lower breast cancer risk for patients with a BRCA1 or BRCA2 mutation include: -bilateral mastectomy which removes most but not all of the breast cells, and reduces risk the most (by 90-95%) -breast MRI and mammogram does not reduce risk but finds breast cancer early when it is more treatable -chemoprevention to prevent getting breast cancer ...Read moreSee 2 more doctor answers
What does angelina jolie's brca test, double mastectomy and oophorectomy mean for the average woman?
For the AVERAGE...: ...Risk woman, it should create awareness about: getting routine screening, knowing your family history well, and living a healthy lifestyle. It should not: make people want genetic tests without reason or make women ask for mastectomies out of fear. Of course, it is important to know if your risk is average or high in order to make the right decisions. Talk to your gyn about this. ...Read moreSee 2 more doctor answers
Yes: BRCA testing can be performed from either blood or saliva. A significant amount of DNA needs to be present for adequate testing so most companies require more than a finger stick blood draw. Usually a single blood tube containing 3 ccs of blood is adequate ...Read moreSee 2 more doctor answers
Please I need help...i want to know the cost of brca gene mutation? And does the test found in all the countaries
Variably expensive: These are very expensive tests and they are not necessary or indicated unless you have a close family history of breast cancer. Even then, having the mutation does not mean that you will definitely have cancer. Better to do annual mammograms and self exams. The tests are available in the US and many other countries but not everywhere and may cost US$2000-4000 ...Read more
What are the pros and cons of getting the brca breast genetic test, if you are just curious about your risks?
$$$$: First and foremost, it is not a good idea to get brca tested if you do not have a strong family history of breast +/-ovarian ca, since the probability is very low and insurance will not cover this ~$3000 test. If you do qualify, it is wise to understand your options if you are brca (+) before the test--there is no point in knowing this if you do not feel comfortable with the options at present. ...Read moreSee 3 more doctor answers
Hi, can you recommend a company that can test me for the brca 1 and 2, that offers international service? My mother died from ovarian cancer at age 57
Not that simple: Just your mother's ovarian cancer is not enough to qualify, for genetic screening. Have to meet other criteria myriad genetic lab has patent on brca I & ii testing, through your doctor out side usa can be tested, by contacting mblom@myriod. Com and it is expensive (most of med insurances will not cover). ...Read more
No one on family has any type of cancer except one great aunt breast cancer @ 71 I am Ashkenazic Jew should I get brca test?
What will do with: The result? Given your family history, you are not likely to have BRCA gene. However, before getting tested, you need to ask yourself, what will you do with the results? Will you get bilateral mastectomy if it is positive? For good health - Have a diet rich in fresh vegetables, fruits, whole grains, low fat milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more
Mother diagnosis with breast cancer at 54, maternal grandmother diagnosis with pancreatic ca at 69. Dr's won't do brca test because there is no other breast/ovarian ca in my family. What do I do? I'm so worried.
Breast cancer: BRCA refers to a set of genes that have been associated to confer a higher risk of developing certain cancers. It was first identified in women with a higher risk of developing breast cancer hence the acronym BRCA. It is associated with breast cancer, ovarian cancer and peritoneal cancer. It can be associated with breast cancer in males as well. ...Read moreSee 3 more doctor answers
Yes: Many studies have been published demonstrating this option to be safe, both for treatment of breast cancer and prevention in women with brca mutations. No surgery will take the risk of subsequent breast cancer down to zero--there is always some breast tissue left behind, albeit microscopic. Therefore, it stands to reason that the more left behind, the higher the risk; yet, it remains quite low. ...Read moreSee 2 more doctor answers
If I end up finding out I am brca + I am 50 is it too late for hysterectomy cause I read need done by 40?
Not too late: It is not too late but you need to consult with an oncologist to find the best surgical options and treatment for you. ...Read more
It is an option...: ...But not the only one. Any person with an inherited cancer trait or a strong family history of cancer should discuss their management with a specialist in cancer genetics. No such thing as one size fits all. Good news is that by knowing you have a mutation, you have the tactical advantage. Best to you. ...Read moreSee 2 more doctor answers
Genetic Counseling: Have you met with a genetic counselor? If not, I strongly recommend this. Testing brca-2 (+) puts you at an increased risk for breast and ovarian cancer (as well as ca of the stomach, pancreas, gallbladder, bile ducts, and melanoma). Options include surgical prophylaxis (mastectomy, oophorectomy), chemoprevention, and close surveillance. These decisions are best made with a professional. ...Read moreSee 2 more doctor answers