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Doctor insights on: Brca Gene For Breast Cancer

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About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?

About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?

50:50 inheritance: Any child of a brca carrier has a 50:50 chance of inheriting that mutation. If they have inherited the mutation, they have a 50-80% chance of developing breast cancer, and an increeased risk of several other cancers. For more information, check this link: http://www. Cancer. Gov/cancertopics/factsheet/risk/brca. ...Read more

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Dr. Barry Rosen
4,316 Doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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How many relatives need to have had breastcancer before you should get genetic testing for the BRCA genes? My mother contracted breast cancer, I am 40

How many relatives need to have had breastcancer before you should get genetic testing for the BRCA genes? My mother contracted breast cancer, I am 40

See genetics: Most breast cancer is NOT due to an inherited risk, but rather occurs by chance. Family history that suggests an inherited risk, such as changes in the BRCA1 gene or BRCA2 gene, include multiple relatives with cancer over more than one generation and younger ages of onset. If you are concerned about an inherited risk, see a geneticist who can assess your family history. ...Read more

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If two members of my immediate family developed breast cancer, should I get tested for the brca gene?

If two members of my immediate family developed breast cancer, should I get tested for the brca gene?

Possibly: It's always better to test the family members who have breast cancer if possible. If they are first degree relatives (mother, daughter or sister) and one was under age 50 at diagnosis, you might meet criteria for brca testing. It's best to meet with a genetic counselor who can help guide you and your family so the correct people are tested. There are non-brca mutations as well. ...Read more

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When I have my daughter tested for brca gene? My husband's sister was diagnosed with stage 3 breast cancer.  no other history of b.C. In our families.

When I have my daughter tested for brca gene? My husband's sister was diagnosed with stage 3 breast cancer.  no other history of b.C. In our families.

Not now: If your sister in law had cancer before age 45 or had a triple negative cancer before age 60, she fits nccn criteria for brca testing even without family history. She needs to test first and if positive, your husband should test and if he is positive, then you test your girl. Cancer can jump an individual but the gene cannot. Hope all goes well with all in the family. ...Read more

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My mother had breast cancer at 54 and her cousin was diagnosed at 45. Is this likely caused by the brca gene? My insurance won't pay for it.

My mother had breast cancer at 54 and her cousin was diagnosed at 45. Is this likely caused by the brca gene? My insurance won't pay for it.

BRCA: Probably not. The patient to be tested is the cousin due to age at diagnosis. You do not qualify because you're risk of having the gene is so low. That's a good thing! ...Read more

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My great grandmother & her sisters all had breast cancer. Her daughter did not, but she died young & only had my dad. Should I get tested for BRCA gene?

My great grandmother & her sisters all had breast cancer. Her daughter did not, but she died young & only had my dad. Should I get tested for BRCA gene?

It's your call: It might be worth doing if the women with breast cancer got it quite early in their lives AND you want to get prophylactic surgery early rather than simply keep up ordinary anti-cancer surveillance. ...Read more

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If negative for brca gene, yet father had prostate cancer, is his daughter still at risk for breast cancer? I heard they were linked.

If negative for brca gene, yet father had prostate cancer, is his daughter still at risk for breast cancer? I heard they were linked.

Not elevated risk: In families who DO have a BRCA mutation, the breast and prostate cancers can be linked. However both are very common cancers, so they can be seen within families even if BRCA negative. The average lifetime risk of breast cancer for any given woman is 12.5%. You can do a search for the Gail Risk Model to get a little better idea of your own personal risk. ...Read more

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My mother was diagnosed with breast cancer at 54, grandmother had pancreatic cancer at 70 and great aunt had colon cancer at 65. No one else has cancer in my large family. Could I have the brca gene?

My mother was diagnosed with breast cancer at 54, grandmother had pancreatic cancer at 70 and great aunt had colon cancer at 65. No one else has cancer in my large family. Could I have the brca gene?

Very Low Risk: The risk of having a brca mutation can be estimated at: http://www. Myriadpro. Com/brca-risk-calculator/calc. Html. A woman with ashkenazi jewish heritage and this family history would have about an 8% chance of having a brca mutation. Without ashkenazi heritage the risk drops to 1.5%. The best way to know for sure would be to have your mother see a genetic counselor and consider having testing. ...Read more

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Can all breast cancer patients carry the brca genes?

Can all breast cancer patients carry the brca genes?

No!: Many patients with breast cancer have no genetic predisposition or risk for breast cancer. However, there are several genetic markers which increase the risk of developing breast cancer over a person's lifetime. ...Read more

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What are the statistics of the brca/breast cancer gene?

Low incidence: Approximately 1 in 40 ashkenazi jewish women have a brca mutation. It also is seen in other isolated populations. A brca1 mutation can be inherited from a mother or father and is associated with up to a 80% lifetime risk of breast cancer and a 40 % risk of ovarian cancer options include increased surveillance chemo prevention or risk reduction surgery. ...Read more

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Mother had lobular breast cancer at 52-- post menopause. Negative for brca genes, atm, p53, cdh1, etc. Is there a strong likelihood i'll get it a well?

Mother had lobular breast cancer at 52-- post menopause. Negative for brca genes, atm, p53, cdh1, etc. Is there a strong likelihood i'll get it a well?

Possible: Various causes result in breast cancer in a family. If BRACA is neg then there is no genetic relationship to getting the Ca. Exposure to the MMTV virus probably results in 80% chance of having a tumor. Also recognized that endogenous sequences of virus can be passed and when proper reorganization of the sequences takes place, the viral genome can induce cancer. ...Read more

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Mother had breast cancer at 54, her cousin had it at 47. Brca negative. Is this likely genetic?

Need more info: Brca 1;2 are not the only genes that can increase the risk for breast cancer so you cannot rule out an inherited trait. That said, they could be sporadic cancers too. I suggest you visit a specialist with expertise in risk assessment and genetics. He/she needs to do a full pedigree and get some personal info to estimate your cancer risk and decide if you (or your mom) need additional testing. ...Read more

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My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?

My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?

No its medullary: A quote from Lancethttp://www. Ncbi. Nlm. Nih. Gov/pubmed/9167459: "The occurrence of invasive lobular carcinoma and invasive ductal carcinoma was not significantly different between carriers of BRCA1 or BRCA2 mutations and controls. Medullary or atypical medullary carcinoma was, however, found more often in BRCA1 (13%, p ...Read more

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My mother had lobular breast cancer at 53. Does this mean ill get it? Is the lobular variety more likely genetic? I'm brca negative.

My mother had lobular breast cancer at 53. Does this mean ill get it? Is the lobular variety more likely genetic? I'm brca negative.

Probably not, no: The lobular variety has similar genetic risk as other varieties. Your mother having breast cancer does mean you have greater than average risk but it is still much more likely that you won't get it than you will. Many genes besides BRCA affect risk, but diet and lifestyle still has a greater influence on risk than genetics. See http://tinyurl. Com/zwgadg2 and http://tinyurl. Com/zg66ou7 ...Read more

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My mother had breast cancer at 54, does this mean i'll get it? Is it still more likely I won't? Brca negative.

Increased Risk: Having a mother with breast cancer doesn't mean that you will get breast cancer for sure. It does put you at increased risk of developing breast cancer. ...Read more

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I have a history of breast cancer. ..and am BRCA + I Recently noticed a dark brown spot on my upper gum it is irregular in shape. 1/4in.? ideas?

I have a history of breast cancer. ..and am BRCA + I Recently noticed a dark brown spot on my upper gum it is irregular in shape. 1/4in.? ideas?

Yes! Get checked!: Anyone with a BRCA mutation is at risk for cancer, including melanoma. This can occur on the gums as well as the skin. The irregular shape and size of 1/4 inch makes your lesion suspicious and worthy of a biopsy, especially because you are BRCA positive. Don't wait... get checked! Hope that helps! ...Read more

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Mother had breast cancer at 54 and her cousin had it at 48.BRCA negative and breast cancer panel negative (breastnext).How likely is it I'll get it?

High Risk: Although genetic testing was negative, you are still at elevated risk. Other factors could help determine statistical risk, but, not as accurate in a 25 yo. I would recommend establishing a relationship w OBGYN +/- a high risk breast program. A yearly breast exam is important. A baseline mammogram at 35 yr and yearly mammograms from age 40 yr would be appropriate. ...Read more

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If my mother had breast cancer at 53, does that mean that I'll get it too? My BRCA was negative and my breasts next panel (TP 53, ATM, STK11, etc.) was negative as well.

If my mother had breast cancer at 53, does that mean that I'll get it too? My BRCA was negative and my breasts next panel (TP 53, ATM, STK11, etc.) was negative as well.

Good question: Remember we don't know all about genes and cancer (will we ever?) so as good as a negative gene panel sounds, you cannot totally rule out an inherited component. If I was counseling you, I would need a full family history and some personal information to estimate your risk as best as humanly possible and see how best to reduce your risk. It's all about odds, dear, cancer is not a certainty 4 u. ...Read more

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My mom had lobular breast cancer at 54 and her paternal cousin had breast cancer at 48. Everyone is brca negative. Is this likely hereditary?

My mom had lobular breast cancer at 54 and her paternal cousin had breast cancer at 48. Everyone is brca negative. Is this likely hereditary?

Hard to tell...: ...without more info. BRCA 1 and 2 are not the only genes known to increase the risk for cancer and there are probably others we do not know anything about. Someone in the family (preferably your mom or her cousin) should visit a genetic counselor (if they have not yet done so) to see what other genes need to be tested if necessary and what else they can do to reduce their risk. ...Read more

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At what age should you be screened for breast cancer or cervical cancer if grandmother and aunt had each at early age in 30s/40s? Brca testing? ;

At what age should you be screened for breast cancer or cervical cancer if grandmother and aunt had each at early age in 30s/40s? Brca testing? ;

See genetics: Early age breast cancer might signal an inherited gene mutation such as the BRCA1 or BRCA2 gene, for which screening would begin around the age of 25. See a geneticist to assess risk for an inherited cancer syndrome. Cervical cancer screening begins by age 21. Family history may be a sign of shared environmental or lifestyle factors but inherited risk unlikely; tell your GYN the family history. ...Read more

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Dr. Barry Rosen
1,365 Doctors shared insights

Breast Cancer (Definition)

Occurs when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. Often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more


Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more