Doctor insights on:
Brca Breast Cancer
Low incidence: Approximately 1 in 40 ashkenazi jewish women have a brca mutation. It also is seen in other isolated populations. A brca1 mutation can be inherited from a mother or father and is associated with up to a 80% lifetime risk of breast cancer and a 40 % risk of ovarian cancer options include increased surveillance chemo prevention or risk reduction surgery. ...Read moreSee 2 more doctor answers
Breast cancer results when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. The growth occurs initially inside the ducts but eventually breaks outside into the breast tissue and ultimately spreads both to the lymph nodes in the armpit and via the bloodstream to other parts of the body. Because of the promoting affect of estrogen almost all breast cancer occurs in women and is a rarity in men. The unregulated growth is due to both inherited and acquired genetic defects. It is the most common malignancy in women but it often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more
70 yo female w/osteoporosis and family hx of BRCA breast cancer. Ok to Denosumab and Reloxifene therapy together??
Yes it is OK: You can take these medicines together. There is no significant interaction or harm. So relax and take them as advised by your doctor. ...Read more
About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?
50:50 inheritance: Any child of a brca carrier has a 50:50 chance of inheriting that mutation. If they have inherited the mutation, they have a 50-80% chance of developing breast cancer, and an increeased risk of several other cancers. For more information, check this link: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca. ...Read moreSee 2 more doctor answers
Mother had breast cancer at 54 and her cousin had it at 48.BRCA negative and breast cancer panel negative (breastnext).How likely is it I'll get it?
High Risk: Although genetic testing was negative, you are still at elevated risk. Other factors could help determine statistical risk, but, not as accurate in a 25 yo. I would recommend establishing a relationship w OBGYN +/- a high risk breast program. A yearly breast exam is important. A baseline mammogram at 35 yr and yearly mammograms from age 40 yr would be appropriate. ...Read moreSee 1 more doctor answer
My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?
No its medullary: a quote from Lancethttp://www.ncbi.nlm.nih.gov/pubmed/9167459: "The occurrence of invasive lobular carcinoma and invasive ductal carcinoma was not significantly different between carriers of BRCA1 or BRCA2 mutations and controls. Medullary or atypical medullary carcinoma was, however, found more often in BRCA1 (13%, p ...Read more
Depends: Many people have a distant relative who had breast cancer late in life and that is not an indication for brca testing. There are certain criteria like very young breast cancer, male breast cancer, triple negative breast cancer before age 60, and others. Visit your family doc or gyn to see if you need a referral to a genetics health professional for testing. ...Read moreSee 2 more doctor answers
No one on family has any type of cancer except one great aunt breast cancer @ 71 I am Ashkenazic Jew should I get brca test?
What will do with: the result? Given your family history, you are not likely to have BRCA gene. However, before getting tested, you need to ask yourself, what will you do with the results? Will you get bilateral mastectomy if it is positive? For good health - Have a diet rich in fresh vegetables, fruits, whole grains, low fat milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more
My mom had lobular breast cancer at 54 and her paternal cousin had breast cancer at 48. Everyone is brca negative. Is this likely hereditary?
Hard to tell...: ...without more info. BRCA 1 and 2 are not the only genes known to increase the risk for cancer and there are probably others we do not know anything about. Someone in the family (preferably your mom or her cousin) should visit a genetic counselor (if they have not yet done so) to see what other genes need to be tested if necessary and what else they can do to reduce their risk. ...Read more
At what age should you be screened for breast cancer or cervical cancer if grandmother and aunt had each at early age in 30s/40s? Brca testing?;
See genetics: Early age breast cancer might signal an inherited gene mutation such as the BRCA1 or BRCA2 gene, for which screening would begin around the age of 25. See a geneticist to assess risk for an inherited cancer syndrome. Cervical cancer screening begins by age 21. Family history may be a sign of shared environmental or lifestyle factors but inherited risk unlikely; tell your GYN the family history. ...Read moreSee 2 more doctor answers
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more