Doctor insights on:
Bortezomib Allergy In Children
Allergies occur when your immune system is triggered by envirionmental factors it should ignore--for example, pollen in the air, or dander on a cat or dog--and creates cells to fight against them. An allergic reaction typically causes itching, congestion, or drainage, and ...Read more
Expensive: A single vial (3.5 mg) of velcade (bortezomib) costs around $1, 500.00. Each cycle of treatment (3 weeks duration) will use about 3-4 vials depending on patient's weight or size. Thus, $ 4, 500-6, 000 per cycle. The duration of treatment can take 4 cycles initially and then continued weekly doses for up to 6 - 8 months. Total cost for treatment could get up to $70-80k not including doctor fees and administration. ...Read more
Neuropathy, etc.: Velcade (bortezomib) or Bortezomib frequently causes a sensory neuropathy with tingling, numbness, pain or a combination in the feet and hands. Thrombocytopenia or low platelets can occur but resolves easily with stopping the drug as does low white count. Giving it under the skin rather than intravenously lessens many side effects especially neuropathy. Beware also of shingles which Acyclovir may prevent. ...Read more
Quite a few: 1. Velcade (bortezomib) can affect nerves. It mainly manifests as numbness an pain in hands and feet. Risk increased with prolonged use and when using the drug twice a week. Risk can be decreased by using it subcutaneously (instead of in a vein) and using it once a week. 2. Many patients report diarrhea on velcade (bortezomib). 3. Velcade (bortezomib) can cause blood counts to go down. ...Read more
They can!: Velcade is also called bortezomib. It is a drug used to treat multiple myeloma and mantle cell lymphoma. Previous treatment for prostate cancer does not make someone unable to receive Velcade, but the side effects from prior cancer treatment might. Velcade causes neuropathy. If someone has neuropathy from prior cancer treatment, it might not be possible to give Velcade. ...Read more
Is neuropathy as a side effect of velcade (bortezomib) transient or durable despite continuation of the treatment
Can be transient: Velcade (bortezomib) can cause peripheral neuropathy. If it causes painful neuropathy or interferes with activity the dose is often decreased. Most of the time if the dose is adjusted or held then the neuropathy improves. But in some patients there can be long-lasting neuropathy. ...Read more
Minimal: It us a fairly well tolerated drug. Its main side effect is neuropathy which can menifest as tingling, numbness of the toes and fingers and lead to weakness in the hands if the drug is continued for long time. But it does recover after stopping or change over to once weekly use. ...Read more
What's the reason for fever with low hemoglobin for 79 yrs old male with multiple myeloma if disease is under control after a year of velcade&melfalan?
Myeloma, treatment: 1) fever - may be from infection with risk from myeloma itself and therapy. Bortezomib (velcade) can increase risk of herpes zoster (shingles). 2) anemia (low hemoglobin) can be from mulitple myeloma and/or the therapies uesd to control it. Check in with your physician. If confusing a repeat bone marrow biopys and other tests may be needed. ...Read more
Is it necessary to take dexa along with Velcade (bortezomib) same day for multiple myeloma patient of 80 yrs as acute diarrhea is encountered after every dose?
See below: Velcade may produce diarrhea, but DEX usually not. Velcade and DEX have been given same day only for the convenience, and I see no reason to try to give them on separate days. Alternatively, one can reduce the dose of Velcade or try anti-diarrhea agent prophylactively, such as imodium (loperamide). Diarrhea needs to be treated with antidiarrhea agents and electrolytes monitoring. ...Read more
Multiple myeloma patient relapsed after Velcade, Revlimid (lenalidomide) and Carfilzomib. Any hope. Patient is 80 yrs old?
Pomalidomide: May try pomalidomide or re-treat with valcade or clinical trial if PS remains good. No sufficient data after carfilzomib failure. ...Read more
My father 80 yrs is under treatment with Velcade (bortezomib) for multiple myeloma a After 2 cycles he is facing acute diarrhea after every injection kindly guide?
In peripheral neuropathy with thalidomide, is lenalidomide a good alternative for newly diagnosed multiple myeloma with velcade (bortezomib) dexamethasone?
Mult. Myeloma relapsed after treatment with velcade (bortezomib), (bortezomib) melphalan&dexamethasone. Melphalan stopped in dec, velcade (bortezomib) in april. Now takes carfilzomib& dexamethasone fever39.5. No infections. What causes fever?
The doctor prescribed melpalan, velcade (bortezomib) and dexamethasone for 78 yrs old male with multiple myeloma. He later increase the dose of melphalan from 10 mg to 14 mg despite the treatment progress. Is this warranted considering high AST and alt?
Speak with physician: The best advice at this point is to speak with the treating physician and ask for an explanation regarding the increase in the medication given the progression of disease on the current treatment. If you are not satisfied with the explanation then by all means seek a second opinion consultation. At times, changes in regimens are easily explained; don't be afraid to ask. ...Read more
Exposure + Genes: One needs both a genetic component and "exposure" to a said allergen to develop an allergy. There is a growing support over the past 20 years, that growing up in an environment which is "too clean" can also lead to development of allergies down the road. Either way, allergies are on the rise. ...Read more
Nut allergy: Maybe. Your children may have inherited genes from you that make them more likely to develop an allergy, but they do not inherit a specific allergy to a food e.g. Nuts. The children have to be exposed to food proteins in the diet, before an allergy can develop. Once one develops an allergy then they are always allergic and need proper medical attention to prevent severe problems. ...Read more
Allergy tests: There are several types of testing. Some involve certain types of blood tests. Another method is to do a series of skin tests done by pricking the skin and applying different allergens. Other tests are provocative tests that can involve challanging the patient with allergic materials. Testing should be done by doctors specializing in allergy to obtain the best results. ...Read more
Skin & blood tests: Prick testing with allergenic extracts or fresh foods can help confirm allergy, as can blood tests for specific ige antibodies (rast-type tests). However, both types of testing can produce false positive results, and confirmation with food challenges may be needed. ...Read more
Not exactly: The ability to react to certain proteins in an allergic way is passed on from parents to their children, but a specific allergy is not. So if a mom is allergic to pollen and the dad is allergic to fire ants, their child may develop allergies but it may be to a food instead. If 1 parent has allergies, the child is 50% likely to develop allergies, but it's a 75% chance if both parents are allergic. ...Read more
Can I as a 46 year old, take children's Benadryl. It's all I have in the house and my allergies are terrible.
Okay to use: Okay to use children's Benadryl. Dosage will be 20 ml (4 teaspoons) per dose. ...Read more
Where can I find a statistic for the number of children who died from allergies causing anaphylaxis in the u.S.?
Only overall numbers: The incidence of anaphylaxis in children is unknown. Estimates of anaphylactic deaths (from drugs, foods, insect stings, and latex) in the us are 0.002 percent annually (2 per 100, 000): 500 fatalities from penicillin anaphylaxis; 40 fatalities from bee stings; 125-150 from food anaphylaxis. ...Read more
My husband has nut and fish allergies. I have 4 children, 2 without allergies should I get rest of kids tested before giving them these foods?
I give my 17mnth old 1/2 teaspoon of children's zyrtec (cetirizine) for allergies but some days it's not enough. Can I increase the dose or try something differ t?
Do not increase: A 17 month old should not have allergies to inhaled items like dust or pollen. Zyrtec (cetirizine) could cause drowsiness and I would avoid long term use of zyrtec (cetirizine) in your child. If your child has a runny or stuffy nose that is unresponsive to zyrtec (cetirizine) then see your doctor to make sure there isn't an infection brewing. ...Read more
Yes: Not all of the food allergies are created equal. Food allergies like dairy, egg, wheat tend to be outgrown. Tree nut and peanut are less likely (although recent studies suggest that 20-30% outgrow the peanut allergy). Environmental allergies tend to "grow on you" with time. Note: the allergy test may remain positive despite the child having outgrown the allergy. Consult with an allergist. ...Read more