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Doctor insights on: Bortezomib

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Dr. Theodore Davantzis
15 Doctors shared insights

Bortezomib (Overview)

Bortezomib is an asthma beta receptor stimulator which is a kind of asthma drug (lung drug).


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What effects can I expect from velcade (bortezomib) chemotherapy?

What effects can I expect from velcade (bortezomib) chemotherapy?

Several: Low blood pressure, peripheral neuropathy (numbness and/or tinging) of the fingers and/or toes, nausea, diarrhea and low blood counts are the most common side-effects of bortezomib. There are many less common side-effects. ...Read more

Dr. Theodore Davantzis
15 Doctors shared insights

Bortezomib (Overview)

Bortezomib is an asthma beta receptor stimulator which is a kind of asthma drug (lung drug).


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The doctor prescribed melpalan, velcade (bortezomib) and dexamethasone for 78 yrs old male with multiple myeloma. He later increase the dose of melphalan from 10 mg to 14 mg despite the treatment progress. Is this warranted considering high AST and alt?

The doctor prescribed melpalan, velcade (bortezomib) and dexamethasone for 78 yrs old male with multiple myeloma. He later increase the dose of melphalan from 10 mg to 14 mg despite the treatment progress. Is this warranted considering high AST and alt?

Speak with physician: The best advice at this point is to speak with the treating physician and ask for an explanation regarding the increase in the medication given the progression of disease on the current treatment. If you are not satisfied with the explanation then by all means seek a second opinion consultation. At times, changes in regimens are easily explained; don't be afraid to ask. ...Read more

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Is neuropathy as a side effect of velcade (bortezomib) transient or durable despite continuation of the treatment

Is neuropathy as a side effect of velcade (bortezomib) transient or durable despite continuation of the treatment

Can be transient: Velcade (bortezomib) can cause peripheral neuropathy. If it causes painful neuropathy or interferes with activity the dose is often decreased. Most of the time if the dose is adjusted or held then the neuropathy improves. But in some patients there can be long-lasting neuropathy. ...Read more

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What side effects can I expect from velcade (bortezomib)?

Neuropathy, etc.: Velcade (bortezomib) or Bortezomib frequently causes a sensory neuropathy with tingling, numbness, pain or a combination in the feet and hands. Thrombocytopenia or low platelets can occur but resolves easily with stopping the drug as does low white count. Giving it under the skin rather than intravenously lessens many side effects especially neuropathy. Beware also of shingles which Acyclovir may prevent. ...Read more

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How much is velcade (bortezomib)?

Expensive: A single vial (3.5 mg) of velcade (bortezomib) costs around $1, 500.00. Each cycle of treatment (3 weeks duration) will use about 3-4 vials depending on patient's weight or size. Thus, $ 4, 500-6, 000 per cycle. The duration of treatment can take 4 cycles initially and then continued weekly doses for up to 6 - 8 months. Total cost for treatment could get up to $70-80k not including doctor fees and administration. ...Read more

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How much is velcade (bortezomib)?

Expensive: A single vial (3.5 mg) of velcade (bortezomib) costs around $1, 500.00. Each cycle of treatment (3 weeks duration) will use about 3-4 vials depending on patient's weight or size. Thus, $ 4, 500-6, 000 per cycle. The duration of treatment can take 4 cycles initially and then continued weekly doses for up to 6 - 8 months. Total cost for treatment could get up to $70-80k not including doctor fees and administration. ...Read more

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What happens when velcade (bortezomib) stops working?

What happens when velcade (bortezomib) stops working?

Ask your docotor!: I am sure there are other medicines that can be used in its place. Depending on what type of cancer you have there are back up options of other drugs which can be used. Velcade (bortezomib) may no longer be useful to you once it stops working. ...Read more

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What side effects can I expect from velcade (bortezomib)?

Neuropathy, etc.: Velcade (bortezomib) or Bortezomib frequently causes a sensory neuropathy with tingling, numbness, pain or a combination in the feet and hands. Thrombocytopenia or low platelets can occur but resolves easily with stopping the drug as does low white count. Giving it under the skin rather than intravenously lessens many side effects especially neuropathy. Beware also of shingles which Acyclovir may prevent. ...Read more

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What effects can I expect from velcade (bortezomib) chemotherapy?

Several: Low blood pressure, peripheral neuropathy (numbness and/or tinging) of the fingers and/or toes, nausea, diarrhea and low blood counts are the most common side-effects of bortezomib. There are many less common side-effects. ...Read more

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I need to find out whether doctors in the united states are using velcade (bortezomib).?

I need to find out whether doctors in the united states are using velcade (bortezomib).?

Absolutely: Velcade (bortezomib) is available in the us for treatment of multiple myeloma and mantle cell non-hodgkin lymphoma. It can now be given either intravenously or subcutaneously which lessens many of its side effects. ...Read more

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What are some of the side-effects of velcade (bortezomib) when treating myeloma patients.

What are some of the side-effects of velcade (bortezomib) when treating myeloma patients.

Quite a few: 1. Velcade (bortezomib) can affect nerves. It mainly manifests as numbness an pain in hands and feet. Risk increased with prolonged use and when using the drug twice a week. Risk can be decreased by using it subcutaneously (instead of in a vein) and using it once a week. 2. Many patients report diarrhea on velcade (bortezomib). 3. Velcade (bortezomib) can cause blood counts to go down. ...Read more

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Why can't someone have velcade (bortezomib) if they previously had prostate cancer?

They can!: Velcade is also called bortezomib. It is a drug used to treat multiple myeloma and mantle cell lymphoma. Previous treatment for prostate cancer does not make someone unable to receive Velcade, but the side effects from prior cancer treatment might. Velcade causes neuropathy. If someone has neuropathy from prior cancer treatment, it might not be possible to give Velcade. ...Read more

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Is neuropathy as a side effect of velcade (bortezomib) transient or durable despite continuation of the treatment

Can be transient: Velcade (bortezomib) can cause peripheral neuropathy. If it causes painful neuropathy or interferes with activity the dose is often decreased. Most of the time if the dose is adjusted or held then the neuropathy improves. But in some patients there can be long-lasting neuropathy. ...Read more

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What are the side-effects of velcade (bortezomib) in the treatment of multiple myeloma?

What are the side-effects of velcade (bortezomib) in the treatment of multiple myeloma?

Minimal: It us a fairly well tolerated drug. Its main side effect is neuropathy which can menifest as tingling, numbness of the toes and fingers and lead to weakness in the hands if the drug is continued for long time. But it does recover after stopping or change over to once weekly use. ...Read more

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What's the reason for fever with low hemoglobin for 79 yrs old male with multiple myeloma if disease is under control after a year of velcade&melfalan?

Myeloma, treatment: 1) fever - may be from infection with risk from myeloma itself and therapy. Bortezomib (velcade) can increase risk of herpes zoster (shingles). 2) anemia (low hemoglobin) can be from mulitple myeloma and/or the therapies uesd to control it. Check in with your physician. If confusing a repeat bone marrow biopys and other tests may be needed. ...Read more

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Is it necessary to take dexa along with Velcade (bortezomib) same day for multiple myeloma patient of 80 yrs as acute diarrhea is encountered after every dose?

See below: Velcade may produce diarrhea, but DEX usually not. Velcade and DEX have been given same day only for the convenience, and I see no reason to try to give them on separate days. Alternatively, one can reduce the dose of Velcade or try anti-diarrhea agent prophylactively, such as imodium (loperamide). Diarrhea needs to be treated with antidiarrhea agents and electrolytes monitoring. ...Read more

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Multiple myeloma patient relapsed after Velcade, Revlimid (lenalidomide) and Carfilzomib. Any hope. Patient is 80 yrs old?

Pomalidomide: May try pomalidomide or re-treat with valcade or clinical trial if PS remains good. No sufficient data after carfilzomib failure. ...Read more

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My father 80 yrs is under treatment with Velcade (bortezomib) for multiple myeloma a After 2 cycles he is facing acute diarrhea after every injection kindly guide?

May/ may not be rela (carisoprodol): Diarrhea is not a common side effect from Velcade. Try taking 2 tablets of Imodium (loperamide) before the next injection. It might be helpful ...Read more

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In peripheral neuropathy with thalidomide, is lenalidomide a good alternative for newly diagnosed multiple myeloma with velcade (bortezomib) dexamethasone?

In peripheral neuropathy with thalidomide, is lenalidomide a good alternative for newly diagnosed multiple myeloma with velcade (bortezomib) dexamethasone?

Possibly: Even though Lenalidomide causes less neuropathy it still occurs. Also depends on the disease. Meaning how aggressive does one need to be. Is there kidney dysfunction? Is the patient of transplant age? ...Read more

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Mult. Myeloma relapsed after treatment with velcade (bortezomib), (bortezomib) melphalan&dexamethasone. Melphalan stopped in dec, velcade (bortezomib) in april. Now takes carfilzomib& dexamethasone fever39.5. No infections. What causes fever?

Mult. Myeloma relapsed after treatment with velcade (bortezomib), (bortezomib) melphalan&dexamethasone. Melphalan stopped in dec, velcade (bortezomib) in april. Now takes carfilzomib& dexamethasone fever39.5. No infections. What causes fever?

Fever could be side: Effects of the chemotherapeutic agents and steroids considering there's no blood infection. Tylenol (acetaminophen) should help control the fever. Follow up with your oncologist. God bless you! Http://www. Livestrong. Com/article/36171-herbs-cancer/. ...Read more

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The doctor prescribed melpalan, velcade (bortezomib) and dexamethasone for 78 yrs old male with multiple myeloma. He later increase the dose of melphalan from 10 mg to 14 mg despite the treatment progress. Is this warranted considering high AST and alt?

Speak with physician: The best advice at this point is to speak with the treating physician and ask for an explanation regarding the increase in the medication given the progression of disease on the current treatment. If you are not satisfied with the explanation then by all means seek a second opinion consultation. At times, changes in regimens are easily explained; don't be afraid to ask. ...Read more

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Is neurogenic bladder a side effect of bortizomib in the treatment of of multiple myeloma?

Is neurogenic bladder a side effect of bortizomib in the treatment of of multiple myeloma?

Possible: Bortezomib, the proteosome inhibitor is licensed for use in multiple myeloma. It has also been used to treat antibody mediated transplant rejection. One side effect is peripheral neruopathy--about 10% of patients. One can speculate that the same mechanism can cause either a failure to emtpy or some urgency of urination. You would need a formal urodynamic assessment to determine this. ...Read more

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Is this free?

Is this free?

Yes, this is free if: If you did not ask for premium, paid services, then this HealthTap BASIC is free. Post your question in English, with good grammar and spelling, and one or more of the thousands of volunteer doctors will answer it. They might skip repetitive questions, or ones that have too many abbreviations, or are otherwise hard to understand. (HealthTap's premium services include virtual medicine appointments) ...Read more

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Are you free?

Are you free?

Yes, this is free if: If you do not request premium, paid services, then this HealthTap BASIC is free. Post your question in English, with good grammar and spelling, and one or more of the thousands of volunteer doctors will answer it. They might skip repetitive questions, or ones that have too many abbreviations, or are otherwise hard to understand. (HealthTap's premium services are personal consultations for a fee.) ...Read more

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Who gets omg?

Who gets omg?

Can you clarify?: Omg is a texting-age expression "oh my god" but used even by secularists to express amazement and dismay at once. It's no medical acronym that I recognize though there are some trashy websites preseting medical freaks as having "omg disease". To which disease are you referring? Someone on healthtap will be happy to answer. ...Read more

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Is this live?

Yes and No: There are doctors on here all of the time. Your questions may get answered immediately or be answered later, depending on the expertise of the doctors online at the time and whether they see your question. ...Read more

Dr. Oscar Novick
17 Doctors shared insights

Velcade (Definition)

Velcade is a cancer-related antibiotic which is a ...Read more