Doctor insights on:
Borderline Lupus Anticoagulant
Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?
Agents which slow ;/or break down blood clot formation in up to 3 different ways (they do not decrease blood viscosity; thickness.) (1) some inhibit platelet function (e.g. Aspirin, clopidogrel, etc.). (2) others interfere with some of the clot forming proteins (warfarin, dabigatran, rivaroxaban, etc.), (3) others stimulate the blood clot destruction ...Read more
All could be: Depending on the spectrum of abnormalities associated with the syndrome all of these tests results could be abnormal. ...Read more
Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?
Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read moreSee 1 more doctor answer
Not always: Unfortunately, there is no single laboratory test that absolutely rules in or out systemic lupus erythematosis (sle). Although a highly positive antinuclear antigen (ANA) is common in sle, diagnosis is based on a careful history, physical exam and laboratory evaluation. ...Read moreSee 1 more doctor answer
What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?
Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more
Seizures mouth ulcers hepatocellular disease low blood count anticardiolipin antibodies 1:80 speckled ANA osteoarthritis spine Si joints LUPUS maybe?
Anti ro ssa was low but present. anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid.has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?
Sjögren's syndrome: Anti-ssa antibodies are most commonly associated with Sjögren's syndrome, but it does not confirm a diagnosis. Pts should may have symptoms of dry eyes and dry mouth, which are classic for Sjögren's syndrome. These ab's are also associated with connective tissue diseases such as lupus or SLE. However, a pt must have clinical and lab abnormalities to meet the diagnosis. ...Read more
Ana direct positive ANA , ifa neg , rnp 2.3, CRP 5.4 ss-b2.7.Diag with lupus connective tissue and sjorgen all at once? Why 2 ANA tests different answ
They can change!: Appears you have mctd with sjogren's like features based on the labs and titers. No lupus marker present! ...Read more
Not necessarily: Although many people with lupus have lupus anticoagulant not all do. And most people with lupus anticoagulant do not have lupus. Patients with lupus are more likely to develop the lupus anticoagulant than the general population so it is one "marker" for the disease. ...Read moreSee 1 more doctor answer
What do these mean? lupus anticoagulant weakly present at 1.30; positive ANA Test 1:40 speckled pattern; negative anticardioliptin and beta2
Not much: A weakly present lupus anticoagulant and an ANA of 1:40 are common in the general population, and usually not an indication of an autoimmune disorder. You should visit with the physician who ordered these tests to review them with you however. A test alone does not give any answers. Doctors will need both a patient's history and tests to determine further management. ...Read more
Developed anca positive vasculitis with antihistone ab 1.4 after 2 months on losartan 50. disc reversedanemia. is angiogenesis critical 4 vasculitis?
This is more than o: Thisis more than one answer. The histone ab is seen in lupus and drug induced lupus. ANCA positivity can mean a variety of issue related to vasculitis but other conditions also, Uncertin about you commetn on anemia. Angigenesis is usually part of a variety of conditions including vasculitis but is seen in non-vaculitis syndromes also. Would advise you disucss this with your rheumatologis ...Read more
Presented w/ inability to walk, joint/muscle pain, hairloss, positive ana, high ssdna, dsdna, ssa (ro), histone, sed rate, could this be lupus?
Yes: It certainly could be lupus. See a rheumatologist as soon as possible. ...Read more
Ana 160:1 with u1rnp 5 u/ml. Other lupus screens negative. Pulmonary hypertension, Renal failure reverses with bicarbonate (sodium bicarbonate). Can it be mtcd/sjogren?
Ana positive strong family history of lupus. Lupus symptoms. Could it be sarcoidosis instead of lupus.
Maybe: ANA positive diseases are related. Diagnosis is based not just on serologic testing, but also on your clinical symptoms. You should be evaluated by a rheumatologist in order to receive an accurate diagnosis and then receive the most appropriate treatment. ...Read moreSee 1 more doctor answer
downs,systemic rheumatoid arthritis, anemia tsh t4 normal has thyriod antibodies hyperthyroid why
Autoimmune disorders: like Rheumatoid Arthritis, diabetes & thyroiditis have an ^ed incidence in children with Down Syndrome (DS). A normal Free T4 & ^ed Ultrasensitive TSH indicates sub-clinical HYPOthyroidism that can become clinical. Macrocytosis, large RBC's, in infants with DS remains lifelong in 2/3rds. It can be associated with anemia from low Vitamin B12 & Folate (folic acid) or iron levels, hypothyroidism or leukemia. ...Read moreSee 1 more doctor answer
Hi Dr,I did lupus anticoagulant test.it shows appt(test)-ls 41.7 observed value.lupus anticoagulant absent means?I have recurrent two abortion
Lupus anti coag: Hello ~ people who have recurrent blood clots to the limbs can in some cases be lupus anti-coagulant positive as a cause and there is increased incidence of natural abortion or miscarriage in those cases. You are lupus anticoagulant negative so its irrelevant as a cause to any clotting disorder. thanks ...Read more
Ana screen positive, ANA titer 320, rash very often on face, nucleolar pattern. Any significance?
1/80 + ana, dual pattern, speckled, centro mere. High aca centromere. High histone ab, igg. See sxs list. Recommendations? Other blood tests -.
Results meaningless: That's right, lab results are meaningless without a history of symptoms, past medical history, family history of related illnesses, previous laboratory tests & your response to medication so far. Without this other information one can only guess at a way to help you. You should be under the care of an experienced rheumatologist. Your primary care provider of local medical society can recommend one. ...Read moreSee 1 more doctor answer
Anticoagulants are any of a variety of drugs which decrease the body's ability to make or sustain blood clots. They fall, generally, into two categories. Drugs like Aspirin and clopidogrel (plavix) prevent platelets from forming the initial stages of a clot. Drugs like warfarin (coumadin) and dabigatran (pradaxa) block the later process ...Read more
If your "lupus anticoagulant" test is positive, it indicates that your blood may clot more easily than it should (long story on the reason for the backwards name). It is important to know that this is only one of several tests for abnormal clotting that a person with an autoimmune ...Read more
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