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Bone Marrow Donor Eligibility
Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more
Under gen anesthesia: Donating bone marrow for transplantation entails a procedure called bone marrow harvesting. The donor is placed under general anesthesia and turned over to lie on his/her belly to expose the hip bones on the back. Multiple aspirations of bone marrow are collected (average about 1 liter) at adjacent sites on the hip bone on both sides until a particular number of cells are reached. ...Read more
The patient is donor: In case of myeloma certain lymphomas in general patients receive chemotherapy , achieve a response and then have stem cells mobilized from their marrow- frozen- patient goes through high doses of chemo to clear the marrow or kill as many tumor cells as possible and then reinfuse cells back. The idea is that high doses of chemotherapy can cause prolong remission or cure ...Read moreSee 2 more doctor answers
BMT from a donor: Allogeneic bone marrow transplantation (bmt) uses another person as the source of stem cells (bone marrow) as opposed to autologous bmt which uses the patient's own cells (usually frozen). Syngeneic bmt uses an identical twin for the donor. Allogeneic donors can be relatives (usually siblings) or totally unrelated. For more info on bmt check out: http://marrow.Org/. ...Read more
Let me explain: 1-we have to have a donor who donate that, we do collect the bone marrow from him we call this step (harvesting) 2-we have to transplant this marrow to the recipient (patient receiving the bone marrow). 3-both involve special collecting method and method of delivery , done under anesthesia use some big needles to harvest. Some time require small surgery under anesthesia. ...Read moreSee 2 more doctor answers
Yes: Both male and female fertility can be affected with either temporary or permanent infertility resulting. Many patients undergoing transplant are already infertile due to the treatment already given for their cancers. There are strategies to preserve sperm or eggs before transplant if desired. ...Read more
Bone marrow : The actual infusion of the cells does not hurt. The side effects of the chemotherapy and/or radiation therapy that are part of the preparative regimen of the transplant can be unpleasant. This can include nausea, vomiting, diarrhea, mouth sores, infections. ...Read moreSee 1 more doctor answer
No: A bone marrow or peripheral blood (pb) stem cell transplant (sct) is not painful. There are various "induction" treatments that depend on the type of cancer or disease to "condition" or get rid of the cancer (& normal) cells. A sct then "rescues" the bone marrow by returning self (autologous sct) cells or cells from another (allogeneic sct). The sct itself is similar to a blood infusion. ...Read moreSee 2 more doctor answers
Many!: Risks are lower if you had your own cells (autologous) or a twin's cells (syngeneic), and higher if you had someone else's (allogeneic). There are short-term and long-term risks. Risks include graft vs host disease, infections (some fatal), liver problems, bleeding, cataracts, infertility, heart damage, lung damage, kidney damage, and others. ...Read more
Aplastic anemia: Aplastic anemia is a condition where for some unclear reason the bone marrow fails to produce normal blood cells. It could be due to underlying genetic mutation plus environmental -i.e. Drugs, chemical agent, infection, etc. Immunosupressant agent has been used to treat aplastic anemia with some response. Allogeneic bone marrow transplant will be the treatment of choice to cure the disease. ...Read moreSee 1 more doctor answer
Yes: This happens on rare occasions, and is not a long term issue for the donor. ...Read more
Yes: People need a performance status to go through transplant. Ideally people should have healed from a broken hip before going through a transplant. Patients after transplant may need steroids and that can make the problem worse. Someone with myeloma or lymphoma needing an auto can have this issue addressed before a transplant to get better benefit ...Read moreSee 2 more doctor answers
Why are umbilical cord stem cells sometimes uses along with donor cells in an allogeneic bone marrow transplant?
One of the other: Stem cells can be obtained from 3 different sources: from Bone marrow of the Donor, blood of the donor or stem cells from umbilical cord. But we have to give an adequate number(Dose) of stem cells in order to have full protection. So combining them may only be needed because of inadequate number of stem cells from one of the sources ...Read more
See below: A bone marrow transplant is the replacement of blood forming elements. The transplant is actually done with peripheral blood stem cells, and infused like a blood transfusion. The need for a transplant is because the treatment for certain diseases requires high doses of chemotherapy or radiation therapy that will destroy one's marrow completely. This then requires replacement with another's marrow. ...Read more
Bone marrow transpla: Bone marrow transplant is a procedure that hematologist/oncologists do for certain indication- for instance- in blood cancer like acute leukemia after remission from chemotherapy, or for certain cases of lymphomas, multiple myelomas- etc. It is not a surgery.Please read from this booklet : http://www.Lls.Org/#/resourcecenter/freeeducationmaterials/treatment/bloodmarrowstemcelltransplant. ...Read more
Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more
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