Doctor insights on:
Bone Marrow Donation Like Spinal Tap
Why are umbilical cord stem cells sometimes uses along with donor cells in an allogeneic bone marrow transplant?
One of the other: Stem cells can be obtained from 3 different sources: from Bone marrow of the Donor, blood of the donor or stem cells from umbilical cord. But we have to give an adequate number(Dose) of stem cells in order to have full protection. So combining them may only be needed because of inadequate number of stem cells from one of the sources ...Read more
Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more
Autoimmune disease: Sjogren's is one of many autoimmune diseases. Organ donation would be very ill-advised since the likelihood that multiple organs are involved with autoimmune disorders is great. They also travel in clusters; for instance, where you have one autoimmune disorder, you are more likely to have another. While it's always awesome to want to donate organs and blood, donating disease is way less awesome :). ...Read more
Bone marrow : The actual infusion of the cells does not hurt. The side effects of the chemotherapy and/or radiation therapy that are part of the preparative regimen of the transplant can be unpleasant. This can include nausea, vomiting, diarrhea, mouth sores, infections. ...Read moreSee 1 more doctor answer
Yes: This happens on rare occasions, and is not a long term issue for the donor. ...Read more
Yes: Mostly hematopoietic (blood) cells and a few mesenchymal (mscs) can be obtained from bone marrow aspiration. Trends in most non-blood applications is to use fat tissues, which have many more mscs that bone marrow. Choice of which depends on specific conditions being treated. ...Read moreSee 1 more doctor answer
Bone marrow harvest: A standard bone marrow biopsy test involves 1 or 2 needle insertions into the iliac crest bone. Depending on the size of the recipient and how many cells are needed it can be from approximately 20-50 needle insertions on each side for a bone marrow harvest/donation. ...Read more
BMT from a donor: Allogeneic bone marrow transplantation (bmt) uses another person as the source of stem cells (bone marrow) as opposed to autologous bmt which uses the patient's own cells (usually frozen). Syngeneic bmt uses an identical twin for the donor. Allogeneic donors can be relatives (usually siblings) or totally unrelated. For more info on bmt check out: http://marrow.Org/. ...Read more
No: A bone marrow or peripheral blood (pb) stem cell transplant (sct) is not painful. There are various "induction" treatments that depend on the type of cancer or disease to "condition" or get rid of the cancer (& normal) cells. A sct then "rescues" the bone marrow by returning self (autologous sct) cells or cells from another (allogeneic sct). The sct itself is similar to a blood infusion. ...Read moreSee 2 more doctor answers
Many!: Risks are lower if you had your own cells (autologous) or a twin's cells (syngeneic), and higher if you had someone else's (allogeneic). There are short-term and long-term risks. Risks include graft vs host disease, infections (some fatal), liver problems, bleeding, cataracts, infertility, heart damage, lung damage, kidney damage, and others. ...Read moreSee 1 more doctor answer
3 yrs lytic bone lesions through axial skeleton -skull. Extramedullary hematopoiesis. New MRI spots on brain-bone marrow expansion. Can this be fatal?
Depends: Bone marrow expansion throughout the skeleton typically signals either that the marrow is i appropriately expanding into these compartment such as in a myeloproliferative disorder or the present regions of marrow production are insufficient to keep up with current body needs. Regardless of the cause this is best answered by hands on evaluation, testing and management by an hematologist. ...Read more
The patient is donor: In case of myeloma certain lymphomas in general patients receive chemotherapy , achieve a response and then have stem cells mobilized from their marrow- frozen- patient goes through high doses of chemo to clear the marrow or kill as many tumor cells as possible and then reinfuse cells back. The idea is that high doses of chemotherapy can cause prolong remission or cure ...Read moreSee 2 more doctor answers
Under gen anesthesia: Donating bone marrow for transplantation entails a procedure called bone marrow harvesting. The donor is placed under general anesthesia and turned over to lie on his/her belly to expose the hip bones on the back. Multiple aspirations of bone marrow are collected (average about 1 liter) at adjacent sites on the hip bone on both sides until a particular number of cells are reached. ...Read more
Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more
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