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Doctor insights on: Bone Marrow Cell Types

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How do they do tissue typing for bone marrow if they just swab your cheek?

How do they do tissue typing for bone marrow if they just swab your cheek?

DNA methodology: Tissue typing is based on hla (human leukocyte antigen) typing originally performed by serologic methods using different known sera to be mixed with white cells (lymphocytes) obtained from the blood. Today, using dna sequencing or PCR (polymerase chain reaction) technology, any tissue in the body (easiest to get is buccal mucosa cells in saliva) could be used as source of dna for study. ...Read more

Bone Marrow (Definition)

Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more


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Can stem cells be extracted from bone marrow. And with that can diabetes type II get any better! thanks?

Can stem cells be extracted from bone marrow. And with that can diabetes type II get any better! thanks?

Second part easy: at most only slightly better. The fundamental problem in type TWO diabetes isnt lack of insulin (typically the insulin level is elevated) it is unresponsiveness/resistance to insulin. So, if the insulin secreting cells were increased, nothing would happen from it. Sometimes, the insulin secreting cells are exhausted in type II but still, with the resistance, inceaeing the number wont help. ...Read more

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Can someone with type 1 diabetes donate bone marrow or stem cells?

Can someone with type 1 diabetes donate bone marrow or stem cells?

Yes: The potential donor would have to be screened based on the entire health picture. Diabetes is not a contraindication to stem cell donation. ...Read more

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Im on dialysis, kidney failure, live donor same blood type, expearment, trick kidney with stem cells and bone marrow, how would i go about it.Get apointmet?

Im on dialysis, kidney failure, live donor same blood type, expearment, trick kidney with stem cells and bone marrow, how would i go about it.Get apointmet?

Check Internet: You should search online for info on centers engaged in this research. Can also visit: http://www.Nationalstemcellfoundation.Org/list-of-treatable-conditions/kidney-transplant/ which has link to research trials and can be a starting point to see which university/research centers are participating. ...Read more

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No abnormal infiltrates in the bone marrow but states 15 percent plasma cells means?

No abnormal infiltrates in the bone marrow but states 15 percent plasma cells means?

Abnormal result: 15% plasma cells is abnormally high. This may be due to several different causes. Sometimes it may be due to an acute infection, or another illness in the body. A more serious cause is Multiple Myeloma. There is also Asymptomatic Multiple Myeloma in which the patient has: normal x-rays, red blood count, blood calcium and kidney function. Only some of these will develop Multiple Myeloma. ...Read more

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Everything in normal range except fr plasma cells in the bone marrow 15 percent means what?

Everything in normal range except fr plasma cells in the bone marrow 15 percent means what?

Tricky: Without an actual examination, I cannot give specific medical advice on your particular health, but an increased number of plasma cells in theory means a cancer of the bone marrow. There would be a LOT of other information you'd have to have before you could say that though. (appearance, activity of the plasma cells, what proteins they put out, genetics maybe, and many other features). ...Read more

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Is there a relation between polyclonal spike n increased plasma cells in the bone marrow pls answer?

Is there a relation between polyclonal spike n increased plasma cells in the bone marrow pls answer?

Relevance?: is there any relevance to any illness? Whenever there is polyclonal spike in the activity of the bone marrow, all cell types may increase in number. Plasma cells are related with B lymphocytes with more complex origination and maturation pattern involving lymphoreticular system. ...Read more

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How n why is it that m spike is below 1 but plasma cells are 15 percent in the bone marrow pls kindly explain?

How n why is it that m spike is below 1 but plasma cells are 15 percent in the bone marrow pls kindly explain?

Immunohistology: Normal plasma cells in your bone marrow would not cause a high M spike. Rarely, abnormal plasma cells do not cause an M-spike. Causes of reactive bone marrow plasmacytosis include infection, malignancy, inflammation, Castleman’s disease, anemia, diabetes mellitus, cirrhosis. In most cases the plasma cell infiltrate is less than 20%, The cytoplasmic light chain ratio differentiates MUGUS ...Read more

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4%plasma cells in bone marrow biopsy-how serious is it?

4%plasma cells in bone marrow biopsy-how serious is it?

Can be normal.: Up to 5% is normal as long as they are not "monoclonal" meaning derived from a cell. If monoclonal then a bone cancer called myeloma needs to be ruled out. If no bone disease, anemia, high calcium or kidney disease answer is MGUS, a pre-cancerous condition with low risk of progression (less than 1% per year). ...Read more

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After what figure of plasma cells in the bone marrow does it affects the cbc?

Multiple myeloma: Over 10% of plasma cell in the bone marrow may show mild anemia. However diagnosis of multiple myeloma is based on the presence of monoclonal protein in the serum and urine along with Plasmacytosis .myeloma affects the bone marrow , bones and kidneys. Screening measures for myeloma not beneficial. As disease advances, plasma cells may show in the peripheral blood. ...Read more

Bone (Definition)

Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more