Doctor insights on:
Bone Marrow Biopsy Sedation
Change in components: A bone marrow biopsy in a normal person will find the pattern of cells most often seen in a healthy person of that age. This would include red cells and their precursers (builders), white cells & precursers, platelet precursers & others. In illness, the pattern changes, and some or all may be abnormal. Tumor cells may take over every space& or few if any normal cells may be seen. ...Read more
A bone marrow biopsy is taken from the pelvic bone. A coring needle is advanced into the bone, which allows one to extract a sliver of the bone marrow, the red part of the bone. It is cut and viewed under a microscope. A bone marrow aspirate, obtained with a syringe, is usually bone at the same time. These are done to diagnose blood problems or to check for tumors in ...Read more
Many Indications: Bone marrow biopsy is most useful in diagnosis and staging of blood cancers (leukemia, lymphoma, multiple myeloma, etc). Also indicated for evaluating unexplained anemia, leukopenia, thrombocytopenia, pancytopenia, or unexplained elevated blood counts. It is also useful for fever of unknown origin, or as a confirmation that bone marrow transplantation is successful. ...Read more
Clarify your questio: In what setting? It depends on what disease, how long you have that, do you have systemic symptoms etc? For more indolent disease - like cll for instance- the chance to see involvement to the bone marrow is pretty high as the disease may have been there for years. For acute leukemia- definitely bone marrow will be abnormal. ...Read more
Low complication: The potential complications from bone marrow biopsy include bleeding and infection. A physician who does the procedure often will have, usually, a low complication rate. In general the rate should be very low (my guess is less than 1%). Remember, the procedure gives information not otherwise obtainable. Discuss with you physician and if you need it- go for it. ...Read more
See below: Almost certainly they will deaden the area before doing the biopsy unfortunately they cannot deaden the bone so when they penetrate the bone for the biopsy there will be some immediate pain but it should be short and you ought to be able to stand it since you know it is going to happen. ...Read more
Bone arrow biopsy: The bones are covered with a tissue called periosteum which has pain nerve fibres and is very sensitive to any injury. The doctor should numb the skin as well as this deeper layer. The needle is large but proper numbing would eliminate most of the pain. Once the numbing wears off, pain returns in a few hours but should be tolerable. Ice or tylenol (acetaminophen) will be helpful. ...Read more
Yes.: Unless its being done under general anesthesia, you should eat and drink (including alcohol) as you would as part of your normal routine. If you are having a general anesthesia, you should take nothing by mouth for 8 hours prior to the procedure. If you are on blood thinners, check with your prescribing doctor to see if its okay to stop these to avoid excessive bleeding at the biopsy site. ...Read more
Depends: It depends on the expected diagnosis. A metastatic tumor may be detected in three days or so. Workup of a hematologic disorder often requires multiple tests and may take a week or longer. ...Read more
Yes, if anesthesia:
Is provided by qualified/ dedicated personell.
For many hospitals it means anesthesiologist and nurse anesthetists and it will depend on the scheduling, availability and logistics. For pediatric patients it should be the norm though ...Read more
Nothing...: They are literally one and the same... The aspiration is the procedure... And then the pathologist looks at the sample as a biopsy specimen. ...Read more
Depends on purpose: How many tests can be done from blood? Millions. How many tests can be done from a bone marrow biopsy (BMB) specimen? Many? What tests should be done? It depends on 1) purpose for performing the BMB and 2) the findings the pathologist sees on morphologic examination of the aspirate & biopsy. Tests may include stains for iron or congo red (amyloidosis) as well as flow cytometry, cytogenetics, FISH. ...Read more
Depends / 1 week: It depends. If the bone marrow is "packed" with cancer cells it may be obvious on an initial review by a hematologist and/or hematopathologist. However, for a new diagnosis I generally tell patients it may potentially be a week for special stains/studies and "send out" studies to fully characterize the bone marrow. ...Read more
Yes: Often a bone marrow biopsy is needed to fully characterize a leukemia, but leukemia may be noted in the peripheral blood when it is smeared on a glass slide (pbs). Also, special tests on blood such as flow cytometry can (at least partially) characterize certain leukemias (eg, cll). ...Read more
Outpatient procedure: A bone marrow biopsy, where a piece of bone marrow is removed cannot be done from the chest (sternum). It's too dangerous to do there. Instead, a bone marrow aspirate is done. The skin is cleaned, the area around the breast bone is anesthetized with local. A special needle is inserted into the bone. You will feel pressure from that. A syringe is used to draw blood. It might hurt briefly. ...Read more
Can you tell me about having a bone marrow biopsy from the chest and what was your experience like?
When the bone: Marrow is sampled from the breast bone only an aspiration can be performed. The bone in this area is not thick enough to perform a biopsy ...Read more
Is a bone biopsy painful? I'm nervous about my upcoming bone marrow biopsy. Is it painful? What sort of pain medication is used? .
Bone marrow biopsy?:
I am not clear what you are asking--do you want to know how much bone marrow is removed during a bone marrow biopsy?
Generally, 5-15 cc's of marrow is removed during a bone marrow aspiration and then a 2-3 cm small piece of the bone marrow is removed for the biopsy.
If you were trying to get other information please add a more detailed question. ...Read more
Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more
Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more
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