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Doctor insights on: Bone Marrow Biopsy Chromosome Analysis Blood Cancer

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Is a bone marrow biopsy better than a chromosome analysis to diagnose blood cancer?

Is a bone marrow biopsy better than a chromosome analysis to diagnose blood cancer?

Yes: Usually, when a bone marrow biopsy/aspirate is done, additional material is collected for special testing, such as flow cytometry and chromosome analysis. While the most important information is obtained by microscopically examining the cells in the bone marrow, the results of those special studies can help the pathologist more specifically diagnose the cancer, if one is present. ...Read more

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Dr. Barry Rosen
4,298 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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How are bone marrow biopsy and chromosome analysis different?

How are bone marrow biopsy and chromosome analysis different?

There is big differe: Bone marrow biopsy is done to obtain a pice of tissue to look under the microscope and find out if the blood formation is normal or abnormal. Chromosomes are not visible in the standard bone marrow biopsy. For this we need to culture the blood cells and capture the chromosomes when they are well formed just before the cells divide. This test takes a laboratory which can culture blood cells to see. ...Read more

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What are the differences between bone marrow biopsy and chromosome analysis?

Different : A bone marrow biopsy is a sampling of the marrow for a host of diagnostic workups. A chromosome analysis entails looking at the genes and structure within the nucleus of a cell. They may come from the bone marrow if needed. ...Read more

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What would a bone marrow biopsy show? They ruled out cancer already.

What would a bone marrow biopsy show? They ruled out cancer already.

It depends,,: it depends on what it was done for. It could be to check on a precancerous condition of the blood like myelodysplastic syndrome or to see if the blood cell lines are sufficient in quantity but this is an extreme test only to be done if other tests are inconclusive or ominous. If cancer had been ruled out, there likely isn't a need for it. See your doctor to find out more info.. Good luck. ...Read more

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Does the presence of bright cd8 t-cells on bone marrow biopsy indicate cancer?

Does the presence of bright cd8 t-cells on bone marrow biopsy indicate cancer?

Not really: Presence of cancer cells is only indication of cancer no other cells., to call it a cancer you have to see cancer cells nothing else . Cd-8 t cells are seen in viral infections also . These cells are some times seen surrounding the tumor or inside the tumor which is a good prognostic sign presence of immunity , body is fighting the cancer. ...Read more

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I was just told that my bone marrow biopsy showed I have a 3rd set of chromosome 8. I have none of the clinical features. Is it possible the test is ?

I was just told that my bone marrow biopsy showed I have a 3rd set of chromosome 8. I have none of the clinical features. Is it possible the test is ?

Trisomy 8 in marrow: This abnormality is not associated with any specific disease, since patients can have different clinical features, such as leukemia, polycythemia vera, and several other blood disorders. It's been suggested that the trisomy may be a secondary rather than primary event in the development of the disease. It's different than trisomy 8 as a primary genetic event-w/ fetal development problem etc. ...Read more

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Why do I black spots in my skull. Revealed by a cat scan. Bone marrow biopsy revealed no cancer?

Why do I  black spots in my skull. Revealed by a cat scan. Bone marrow biopsy revealed no cancer?

DDx: I see a lot of multiple myeloma, so i think of lytic (punched out) lesions in the skull (calvarium) as myeloma. However other cancers such as squamous cell cancers (head/neck, lung, etc) can produce lytic lesions. Sometimes veins going through bone can produce "holes" that are normal. The differential diangosis (ddx) is broad -- eg http://www.Calvariallesions.Com/index.Html. ...Read more

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How to cure blood cancer after bone marrow transplantation?

How to cure blood cancer after bone marrow transplantation?

Unclear ?: Are you saying that the bone marrow transplantation did not cure the blood cancer? If that is your question, then the choices are limited. You should consult another bone marrow transplant experrt and seek his/her input. Bone marrow transplant can sometimes be repeated...As one option. There are also new/experiemntal drugs which can still help even after failure of the transplant. ...Read more

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Please help me in this .. Tell me what is considered the best next step to cure blood cancer after the bone marrow transplant fails ..?

Please help me in this .. Tell me what is considered the best next step to cure blood cancer after the bone marrow transplant fails ..?

I am afraid, not man: Not many options , if one gets to this stage. However bone marrow trasplant can be repeated. If this is not possible, then you are at the mercy of some brand new phase 1 or phase 2 clinicla trials which are often running in major cancer centers like md anderson or sloan kettering cancer center. Fred hutchinson cancer center in seattle is another well known place to search for any good options ther. ...Read more

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My blood test for jak2 was negative but blood counts are still rising would you recomend bone marrow biopsy?

Yes: Jak2 testing is supportive of certain myeloproliferative diagnsoses, but the clinical decision to pursue the bm biopsy will be driven by the extent and pace of rise and your symptoms. ...Read more

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I had a bone marrow biopsy done today bc my Hgb is 7.8, my red and whit blood counts are both low. I am asymptomatic. Any idea?

I had a bone marrow biopsy done today bc my Hgb is 7.8, my red and whit blood counts are both low. I am asymptomatic. Any idea?

Anemia. : Is your platelet count low, too? There are myriad causes of anemia, but not all of them require a bone marrow biopsy to diagnose, so I'll assume you're pretty far down the diagnostic path. At this point, your best bet would be to wait for the biopsy results. Preliminary information doesn't take too long to come in. Good luck. ...Read more

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Is it possible to have a normal white blood count, and end up diagnosed with myelodysplastic syndrome from a bone marrow biopsy?

Yes: It is a little confusing, but it is possible. We have 3 different cell lines in our blood: white blood cells, red blood cells and platelets or clotting cells. They all start their maturation in the marrow with young forms that evolve in mature, circulating cells. Myelodysplasia can affect 1, 2 or all cell lines and will eventually affect the number and/or the proportion of immature forms in blood ...Read more

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If blood work has not shown the cause of my polycythemia, will a bone marrow biopsy be helpful? My hematologist has mentioned it, but not done it.

If blood work has not shown the cause of my polycythemia, will a bone marrow biopsy be helpful? My hematologist has mentioned it, but not done it.

It may or maynot: The diagnosis of polycythemia requires several criteria which are well defined. They include CBC, Hb level, WBC level, platelets and Blood erythropoetin level. Send us the results and we can help you. Unless your Hb is above 17 grams, you can get a follow up CBC in 2-3 months and see if it is rising. ...Read more

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Platelets hover between 96-160k, also get weak/aches. All other blood work stays normal. Would this still warrant a bone marrow biopsy?

Platelets hover between 96-160k, also get weak/aches. All other blood work stays normal. Would this still warrant a bone marrow biopsy?

Not necessarily: If all other blood test results are normal, you do not have any abnormal bleeding, you may wish to wait and watch. If the platelet count stays stable at its current level, it will not be an issue and will not cause any problems. You should follow your doctor's advice for repeat tests. ...Read more

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My mom in law bone marrow report says low grade unclassified b cell lymphoproliferative disorder what does it suggest is it a blood cancer?

My mom in law bone marrow report says low grade unclassified b cell lymphoproliferative disorder what does it suggest is it a blood cancer?

Yes, more w/u needed: Yes, low grade b cell lymphoproliferative disorder a.K.A lymphoma is a type of blood cancer. There are many types of b cell lymphoproliferative disorder from the low grade/less agressive to high grade/more agressive. Here, i think, more work up needs to be done- particularly to classify what type of lymphoproliferative disorder this is and also how much tumor burden and prognostication. D/w md. ...Read more

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Can a bone marrow biopsy cause blood in the stool?

Can a bone marrow biopsy cause blood in the stool?

No: No, bone marrow biopsy is taken from the hip bone, they don't go close to the bowels , you should get evaluated though for the bloody stools ! ...Read more

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Dad was prescribed pyrodixine to treat his moderate anemia after bone marrow biopsy and aspiration done. Dr. Said no cancer. What s diagnosis options?

Dad was prescribed pyrodixine to treat his moderate anemia after bone marrow biopsy and aspiration done. Dr. Said no cancer. What s diagnosis options?

Anemia: Did they tell you the bone marrow findings? I would be interested in iron content of the bone marrow. He could have nutritional anemia Or sideroblastic anemia .. You should discuss this with his hematologist ...Read more

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After bone marrow biopsy done to my 70 yr dad , hematologist gave him vitamin B6 for his moderate anemia. What s possible diagnosis. Dr. Say no cancer?

After bone marrow biopsy done to my 70 yr dad , hematologist gave him vitamin B6 for his moderate anemia. What s possible diagnosis. Dr. Say no cancer?

Sideroblastic?: Some of the sideroblastic anemias respond to generous doses of pyridoxine. I hope this works. This is a large and diverse family illnesses most bearing a mutation or two in the marrow. You may enjoy reading up on them. Best wishes. ...Read more

Dr. Pen Hou
117 doctors shared insights

Bone Marrow Biopsy (Definition)

A bone marrow biopsy is taken from the pelvic bone. A coring needle is advanced into the bone, which allows one to extract a sliver of the bone marrow, the red part of the bone. It is cut and viewed under a microscope. A bone marrow aspirate, obtained with a syringe, is usually bone at the same time. These are done to diagnose blood problems or to check for tumors in ...Read more


Dr. Chad Levitt
2 doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more