Top
20
Doctor insights on: Bone Marrow Biopsy Chromosome Analysis

Share
1

1
How are bone marrow biopsy and chromosome analysis different?

How are bone marrow biopsy and chromosome analysis different?

There is big differe: Bone marrow biopsy is done to obtain a pice of tissue to look under the microscope and find out if the blood formation is normal or abnormal. Chromosomes are not visible in the standard bone marrow biopsy. For this we need to culture the blood cells and capture the chromosomes when they are well formed just before the cells divide. This test takes a laboratory which can culture blood cells to see. ...Read more

Dr. Pen Hou
117 doctors shared insights

Bone Marrow Biopsy (Definition)

A bone marrow biopsy is taken from the pelvic bone. A coring needle is advanced into the bone, which allows one to extract a sliver of the bone marrow, the red part of the bone. It is cut and viewed under a microscope. A bone marrow aspirate, obtained with a syringe, is usually bone at the same time. These are done to diagnose blood problems or to check for tumors in ...Read more


2

2
Will a bone marrow transplant cure bone marrow cancer?

Will a bone marrow transplant cure bone marrow cancer?

Yes: However it depends on the type of cancer, if it is in remission or not ,age of the patient and the type of donor. It also depends on the type of transplant, from self or another donor ...Read more

See 1 more doctor answer
4

4
Is a bone marrow biopsy better than a chromosome analysis to diagnose blood cancer?

Is a bone marrow biopsy better than a chromosome analysis to diagnose blood cancer?

Yes: Usually, when a bone marrow biopsy/aspirate is done, additional material is collected for special testing, such as flow cytometry and chromosome analysis. While the most important information is obtained by microscopically examining the cells in the bone marrow, the results of those special studies can help the pathologist more specifically diagnose the cancer, if one is present. ...Read more

See 1 more doctor answer
5

5
Bone marrow Biopsy showed 2 genetic abnormality. Another bone marrow done in same center showed no abnormalities. No treatment done. Any explanation?

Bone marrow Biopsy showed 2 genetic abnormality. Another bone marrow done in same center showed no abnormalities. No treatment done. Any explanation?

Cytogenetic analysis: A bit more complicated. Not enough information to assess.Need more details on the exact type of genetic abnormality. Would be helpful to be able to view the entire genetic evaluation, complete blood count and history. Suggest that you seek a full one on one consultation. Good luck. ...Read more

6

6
Is bone marrow biopsy done without anesthesia?

Is bone marrow biopsy done without anesthesia?

Just for children: Young children will generally be put to sleep. The rest will at least get local anesthesia which is like novacaine over the hip. ...Read more

9

9
4%plasma cells in bone marrow biopsy-how serious is it?

Can be normal.: Up to 5% is normal as long as they are not "monoclonal" meaning derived from a cell. If monoclonal then a bone cancer called myeloma needs to be ruled out. If no bone disease, anemia, high calcium or kidney disease answer is MGUS, a pre-cancerous condition with low risk of progression (less than 1% per year). ...Read more

10

10
What are the differences between bone marrow biopsy and chromosome analysis?

Different : A bone marrow biopsy is a sampling of the marrow for a host of diagnostic workups. A chromosome analysis entails looking at the genes and structure within the nucleus of a cell. They may come from the bone marrow if needed. ...Read more

See 1 more doctor answer
11

11
Is a bone marrow biopsy painful?

Yes and no: Any biopsy will be painful but in the hands of an experienced doctor and proper sedation (local novocaine) it can be a much more tolerable process. Pain killers such as tylenol (acetaminophen) afterwards for 24-58 hours can be a help too. ...Read more

12

12
Will nephrogenic systemic fibrosis be detected in a bone marrow biopsy?

Will nephrogenic systemic fibrosis be detected in a bone marrow biopsy?

Not necessarily: Nephrogenic systemic fibrosis (nsf), also known as nephrogenic fibrosing dermopathy (nfd), is a disease of fibrosis of the skin and internal organs reminiscent but distinct from scleroderma or scleromyxedema. It is caused by gadolinium exposure used in imaging in patients who have renal insufficiency. ...Read more

See 1 more doctor answer
13

13
Is bone marrow transplantation is curative for chronic myeloid leukemia caused by (Philadelphia chromosome) ?

Is bone marrow transplantation is curative for chronic myeloid leukemia caused by (Philadelphia chromosome) ?

Yes: In 70 to 80 percent of cases. The availability of tyrosine kinase inhibitors such as gleevec (imatinib) has moved transplant to 3rd line treatment ...Read more

14

14
Do bone marrow aspirations mean leukemia?

Do bone marrow aspirations  mean leukemia?

No: We do them for several reasons including evaluation for an abnormal cbc. Sometimes we are concerned about leukemia but the other reasons include the following: anemia, low platelets, staging of lymphoma, monitoring therapy. Hope this helps. ...Read more

See 1 more doctor answer
16

16
What amount is a bone marrow biopsy?

What amount is a bone marrow biopsy?

Bone marrow biopsy?: I am not clear what you are asking--do you want to know how much bone marrow is removed during a bone marrow biopsy? Generally, 5-15 cc's of marrow is removed during a bone marrow aspiration and then a 2-3 cm small piece of the bone marrow is removed for the biopsy. If you were trying to get other information please add a more detailed question. ...Read more

17

17
What makes an a bone marrow biopsy abnormal?

What makes an a bone marrow biopsy abnormal?

Change in components: A bone marrow biopsy in a normal person will find the pattern of cells most often seen in a healthy person of that age.This would include red cells and their precursers (builders), white cells & precursers, platelet precursers & others. In illness, the pattern changes, and some or all may be abnormal. Tumor cells may take over every space& or few if any normal cells may be seen. ...Read more

19

19
Are bone marrow biopsies ever false?

Rarely: Keep in mind that there is no such thing as 100% in life or in medicine. For every test we do, there is some chance (which may be very, very small) that the result will be incorrect. ...Read more

See 2 more doctor answers
20

20
Can getting a bone marrow biopsy hurt?

Can getting a bone marrow biopsy hurt?

It will hurt: Even with a local anesthetic and some sedation, you can expect a fair amount of pain. Be brave and remember that it's being done to promote your improved health. ...Read more

Dr. Andrew Berry
2 doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more


Bone Marrow (Definition)

Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more