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Doctor insights on: Bone Marrow Biopsy Chromosome Analysis

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How are bone marrow biopsy and chromosome analysis different?

How are bone marrow biopsy and chromosome analysis different?

There is big differe: Bone marrow biopsy is done to obtain a pice of tissue to look under the microscope and find out if the blood formation is normal or abnormal. Chromosomes are not visible in the standard bone marrow biopsy. For this we need to culture the blood cells and capture the chromosomes when they are well formed just before the cells divide. This test takes a laboratory which can culture blood cells to see. ...Read more

Dr. Pen Hou
106 doctors shared insights

Bone Marrow Biopsy (Definition)

A bone marrow biopsy is taken from the pelvic bone. A coring needle is advanced into the bone, which allows one to extract a sliver of the bone marrow, the red part of the bone. It is cut and viewed under a microscope. A bone marrow aspirate, obtained with a syringe, is usually bone at the same time. These are done to diagnose blood problems or to check for tumors in ...Read more


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What are the differences between bone marrow biopsy and chromosome analysis?

Different : A bone marrow biopsy is a sampling of the marrow for a host of diagnostic workups. A chromosome analysis entails looking at the genes and structure within the nucleus of a cell. They may come from the bone marrow if needed. ...Read more

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Is a bone marrow biopsy better than a chromosome analysis to diagnose blood cancer?

Is a bone marrow biopsy better than a chromosome analysis to diagnose blood cancer?

Yes: Usually, when a bone marrow biopsy/aspirate is done, additional material is collected for special testing, such as flow cytometry and chromosome analysis. While the most important information is obtained by microscopically examining the cells in the bone marrow, the results of those special studies can help the pathologist more specifically diagnose the cancer, if one is present. ...Read more

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I was just told that my bone marrow biopsy showed I have a 3rd set of chromosome 8. I have none of the clinical features. Is it possible the test is ?

I was just told that my bone marrow biopsy showed I have a 3rd set of chromosome 8. I have none of the clinical features. Is it possible the test is ?

Trisomy 8 in marrow: This abnormality is not associated with any specific disease, since patients can have different clinical features, such as leukemia, polycythemia vera, and several other blood disorders. It's been suggested that the trisomy may be a secondary rather than primary event in the development of the disease. It's different than trisomy 8 as a primary genetic event-w/ fetal development problem etc. ...Read more

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Can getting a bone marrow biopsy hurt?

Can getting a bone marrow biopsy hurt?

It will hurt: Even with a local anesthetic and some sedation, you can expect a fair amount of pain. Be brave and remember that it's being done to promote your improved health. ...Read more

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How painful is a bone marrow biopsy typically?

It depends: Some people have a higher pain tolerance than others. Even at the hands of the most skilled physician, a bone marrow biopsy is at least uncomfortable. ...Read more

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How can you make a bone marrow biopsy less painful?

How can you make a bone marrow biopsy less painful?

Sedation: Light sedation can be used, in addition the soft tissues should be numbed to the periosteum, the outer layer of bone. ...Read more

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What can I do about pain in the bone marrow biopsy?

What can I do about pain in the bone marrow biopsy?

Bone marrow biopsy: If it is done after adequate local anesthesia is used with lidocaine, it should not hurt, maybe little pressure or discomfort at site. After procedure you can take an aleve, advil or tylenol (acetaminophen) to alleviate the pain. ...Read more

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4%plasma cells in bone marrow biopsy-how serious is it?

Can be normal.: Up to 5% is normal as long as they are not "monoclonal" meaning derived from a cell. If monoclonal then a bone cancer called myeloma needs to be ruled out. If no bone disease, anemia, high calcium or kidney disease answer is MGUS, a pre-cancerous condition with low risk of progression (less than 1% per year). ...Read more

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Could you explain what is a bone-marrow biopsy used to treat?

To diagnose not to: Treat. Bone marrow biopsy is a diagnostic process for disorders of blood and sometimes bone and some cancers. It is not a treatment for any disease. See this site for more info. http://www.nlm.nih.gov/medlineplus/ency/article/003934.htm. ...Read more

Dr. Milton Alvis Jr
2 doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more


Bone Marrow (Definition)

Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more