Doctor insights on:
Biological Molecules Involved Diabetes
Are there medicines that work by targeting tau proteins or beta amyloid in Alzheimer's disease? Or gene therapy to replace faulty proteins?
Not yet: This is an active field of research but none are currently available or approved. ...Read more
Likely numerous: Examples: Changes in barometric pressures or weather may provoke migraine headaches. Multiple sclerosis may be triggered by low contact with sun and secondary low Vitamin D. Presence of parasitic infections may protect against autoimmune disorders. It goes on and on, but the above gives an idea of the complexity. ...Read more
How could modern genetic studies contribute to our understanding of biological variation in humans?
Understand : Helps us see how changes occurGet a more detailed answer ›
Is there research into any genetic, autoimmune or other condition that links nerve sheath disorders (tarlov cysts, nerve sheath tumor) with autoimmune hypophysitis targeting acth cells? Ctla-4 gene?
Immune modulation: Ipilimumab is a drug used to treat melanoma. It targets ctla-4, which is a t cell receptor that downregulates part of the immune system. A side effect has been described: autoimmune hypophysitis (inflammation of the pituitary) which can knock out many hormones, including acth. There are a few articles on this. Torino et al, oncologist 2012; 17:525. ...Read more
Is effectively controlled htn, lipids, and glucose considered a risk factor for cad, absent of other risk factors (i.E. Genetic)?
What makes immune cells only attack one type of antigen, as opposed to multiple different antigens?
It's complicated: When immune cells come into contact with a foreign substance (called an antigen), they engulf that substance and either start making antibodies to it or activate other immune cells to come into the area to fight off the foreign invader. Antigens are fairly specific so antibodies that form are also fairly specific. Sometimes mistakes occur however. Here's a link to more: http://bit.ly/1uy9lyG ...Read more
Hemostasis: Hemostasis is a complex process involving cellular blood components (platelets) and humoral or serum (liquid) components. There are organs involved in production of those components (chiefly bone marrow and liver) but these are not directly involved in the processes of hemostasis. ...Read more
With bipolar ii, adhd, & c ptsd, what additional tests are beneficial? Ie: hormone, neurotransmitter , DNA mutation (mthfr, a1at ...) methylation etc.
Yes: I would definitely check mthfr and comt. Both these are involved in methylation. One is involved in neurotransmitter synthesis, and the other in breakdown. Therefore polymorphisms can impact mood, etc, and if so, vitamins and supplements can help the methylation cycle. I check mthfr in most of my patients. ...Read moreSee 4 more doctor answers
Safety: Patient safety is the most important key besides effectiveness. ...Read more
Is there a name for all the chemicals like cytokines, chemokines, and growth factors that are in the immune and lymphatic system, like immune factors?
Signaling: proteins, is what all of these terms do functionally. Chemokines are cytokines. And many use the term cytokine and growth factor interchangeably but the name growth factor tends to imply a proliferative effect on cell division/growth while cytokines can have both stimulant or inhibitory effects on cell growth/division. ...Read more
Social interaction: Genetic issues are not really understood. Autism spectrum disorders are complex and evolve over time. We are seeing more children in whom autism symptoms resolve as they mature. Applied behavioral analysis and social interaction contribute much. ...Read moreSee 1 more doctor answer
Complement: The complement system helps antibodies and phagocytic cells clear pathogens. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system. Generally synthesized by the liver. Stimulated by one of several triggers....Etc. ...Read more
What type of autoimmune disease attacks only brain cells and neurons without antibodies in blood work ?
Autoimmune brain dz: Answers to your question include multiple sclerosis, rasmussen encephalitis, sometimes paraneoplastic diseases. Vasculitis conditions are numerous - some are not named. These attack blood vessels though, not neurons. Many of them have no blood test marker. ...Read moreSee 2 more doctor answers
Can an autoimmune disease effect our nerves, brain cells , neurons, and part of our brain, so we lose our emotions feelings, empathy, inhibitions, ?
Possible: It all depends on the kind of autoimmune disease and place of involvement. For instance, lupus could cause cerebritis ie brain inflammation and even could go as far as causing coma. But lupus could be only localized to other places like causing kidney disease, lung diseases, skin disease, or arthritis. ...Read more
Many: Since there are many types of stroke, this is a very complicated question. Most strokes are related to atherosclerosis ( fat deposit in the arteries). So the genes involved ( there are many) in lipid (fat) metabolism and blood pressure regulation are important. One important set of genes seems to be located on chromosome number 9. In any case this is an active area of medical research. ...Read moreSee 1 more doctor answer
What categories does severe combined immunodeficiency fall under? (such as single gene defect, point mutation. Chromosome abnormality, sex-linked, etc
Still research: Stem cells and cloning are research tools but they offer the hope of treating some disorders that may not have any other successful treatments. Consider new pancreas cells to treat diabetes, cells to correct parkinsons, etc. I doubt anyone has a good idea of where cloning will be of benefit. Any technology can be abused but let's focus on the good hopeful uses. ...Read more
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