Doctor insights on:
Bilirubin is the potentially toxic product of heme metabolism. It is formed by breakdown of heme present in hemoglobin, myoglobin, cytochromes, catalase, peroxidase and tryptophan pyrrolase. Eighty percent of the daily bilirubin production comes from hemoglobin. It requires conversion to a water-soluble form before elimination from the body by ...Read more
I have slightly high bilirubin total, indirect, direct and transaminase. Meaning of this?. No hepatitis a b or c. What is cause and what to do?
Continue workup: I trust the workup is going on with you alcohol-free, and perhaps you should stop taking all that iboprofen as this is a famous cause of what you're describing. You may need to be checked for hemochromatosis, wilson's, autoimmune hepatitis, maybe antitrypsin deficiency. If they're still up, it may be a "fatty liver" begging you to exercise more -- think about hitting the fitness hard now. ...Read more
Bilirubin has been high on and off for 2 years. Did have a fatty liver but enzymes are normal since June could they b high due to something serious?
Liver injury?: Elevated liver enzymes indicate liver cell injury (enzymes leak outside the injured cells). Fatty liver disease (steatosis) can become more active when some of the liver cells can no hold no more fat so they rupture and thus add an inflammatory component to the process (it becomes steato-hepatitis) ...Read moreSee 1 more doctor answer
Depends: It depends on the age of the patient and the level of the jaundice. Jaundice in adults is not as dangerous in that the bilirubin (which causes the jaundice) is not damaging, but it can indicate a condition that is (liver failure.) in babies, a high level of bilirubin can lead to a condition where the bilirubin gets into the brain and causes permanent damage to the developing brain cells. ...Read more
Three mechanisms: High bilirubin that is almost all unconjugated means hemolysis (tearing up red cells too fast) or gilbert's non-disease. If it is mostly conjugated, the bile ducts are obstructed, perhaps by a stone or tumor. If both are way up, probably the liver cells are being damaged. ...Read moreSee 1 more doctor answer
Reference range: Most health adults have bilirubin at or below about 1.4 mg/dl with some variability from lab to lab. Remember that the reference range is not the healthy, "normal" or even "desirable" range. Several percent of humankind of gilbert's non-disease with somewhat higher bilirubins; treating this will simply make you sick. Talk with your physician about any concerns. ...Read more