Doctor insights on:
Bilirubin Liver Failure
Let's reframe the ?: The issue isn't the amount of bilirubin causing problems with the liver. The liver is likely infiltrated with tumor mets and therefore is not able to process bilirubin. The elevated bilirubin can have multiple causes but is a symptom of the liver failure rather than the cause. It can also be a symptom of obstruction of the biliary system in the liver by tumor or simply inactivity (cholestasis). ...Read more
This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more
Not necessarily: How high is the bilirubin and what type is it? High bilirubin can be due to bile duct obstruction, genetic causes, and also liver injury. All lab results need to be interpreted in the clinical context and the doctor who ordered the test is usually in the best position to do that. ...Read more
Mcrc patient. Bilirubin rising as
Other liver tests are okay.will this lead to liver failure? No blockage seen
Are you on Stivarga?: I found "Interrupt and then reduce or discontinue STIVARGA for hepatotoxicity as manifested by elevated liver function tests ...." and "... Monitor liver function tests weekly in patients experiencing elevated liver function tests until improvement to less than 3 times the upper limit of normal (ULN) or baseline values." You are above 3 times normal. Reduce or stop. Call your PCP re liver failure ...Read more
Taken paracetomol 2g/day for 15 day upto 31.08.16.LFT on 19.09.16- bilirubin 0.5, SGOT 28,SGPT 51. Skin, eyes yellow & drowsy. Is it liver failure?
Why are you taking paracetamol? Who ordered the lab tests? It would be prudent to discuss it with the doctor who ordered the tests. The "yellow' color of your eyes and skin is not due to liver disease, or jaundice.
For good health — Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Drink enough water daily so that your urine is mostly colorless.
Practice safe sex. ...Read more
Total protein 7.7, Albumin 4.0, total bilirubin 0.4, ALP 131 (norm up to 116), ALT 55, AST 24. Concern for liver failure? Doc said nothing onhigh ALP
Alkaline phosphatase: It is difficult to interpret labs without knowing the medical setting under which they were drawn. Having said that, there are many things besides liver issues that can cause a slight increase of alkaline phosphatase. I would recommend talking to your doctor about this, and perhaps having a repeat blood draw in 1 to 2 months. Good luck. ...Read more
My prothrombin time is INR 1.3 with normal aptt and platelet counts. Do I have liver failure? Normal ast, alt, alp and bilirubin. Burns right stomach
Probably not: The slight elevation in the INR with normal labs for the rest of your liver functions suggests you don't have liver disease. The burning could be coming from an ulcer, or gastritis, or esophagitis. The body doesn't do a good job of localizing pain coming from the internal organs, so where you feel the pain may not be where it is. Follow up with your doctor to check out different causes. ...Read more
Three months ago direct and total bilirubin were double the normal level. Now they're normal again. Cirrhosis? Liver failure? Hepatitis?
May be gallstones.: Possible gallstones. Glad it returned to normal. ...Read more
Yes: Chronic hepatitis b can cause the liver to develop severe scarring from the longstanding inflammation the virus causes. The scarring, commonly referred to as cirrhosis, can be progressive such that more and liver function is lost to scarring. Eventually there are too few healthy liver cells to remove toxins from the body and liver failure happens, usually over a period of years. ...Read more
Definitely: You need your liver to live. It's the master biochemist in the body; makes proteins, bile, clotting factors, detoxifies drugs, chemicals, poisons, etc. Death from liver failure usually is not pretty; can be associated with abdominal fluid collection (ascites), which can get infected, altered mental status (with or without coma), weight loss, bleeding from varicose veins of esophagus stomach, etc. ...Read more
Bad things happen: The liver is necessary for life, so if the liver fails, bad things happen. Toxic chemicals that are natural byproducts of the human body start to build up (such as ammonia) and damage many organs. Necessary proteins that a normal liver makes, are no longer made (such as Albumin and the clotting proteins). Without albumin, a major protein in blood plasma, a person will swell up with fluid.... ...Read more
Rarely: It is rare to have liver damage secondary to malaria and when it happens it is the result of a coexisting liver condition such as viral hepatitis and chronic liver disease. Malaria caused by plasmodium falciparum may cause liver failure esp if it s is recurrent. As you will see the life cycle of malaria involves liver, however again the damage is rare. ...Read more
Talk to doc: I am sorry to hear the trouble you are having. Hallucinations due to liver failure are most likely to be a direct effect of abnormal levels of chemicals that the liver normally clears from the blood. Please discuss this asap with your liver doctor or some one covering for him/her. ...Read more
Semantics: Hepatotoxicity is exposure of the liver to something that makes it sick. This may be acute, subacute, or chronic. Liver failure, similarly may be acute, chronic and compensated, or chronic and decompensated. A failing liver implies significant loss of liver function. Both scenarios should be avoided. In either case, stay away from alcohol, and ask your doctor for lifestyle, diet, rx advice. ...Read more
Absolutely, yes!: It is fortunately less common these days, but acute hepatitis a/b can cause liver failure, and those of toxic side effects of medications especially chemo/biologic agents. Drug overdose such as tylenol (acetaminophen) can cause fulminant liver failure and aweful death. There are other causes, but less common. If you have trouble, please consult your doc. Good luck. ...Read more
Not long: If these organs truly stopped working completely, survival would be short 1-2 weeks at most. ...Read more
Alcohol liver dz.: Sxs of liver disease due to alcoholism may include: nausea, vomiting, drop in appetite, weight loss, abdominal pain & bloating, yellowing of skin & eyes, itching, numbness of legs/ feet, memory problems, cognitive difficulties, depression, fatigue & thirst. If you have these sxs — please get immediate medical help. You can work with an addiction medicine specialist & alcoholics anonymous. ...Read more
Depends: There are 2 main categories of liver failure-- compensated or uncompensated. Compensated means that the liver while profoundly injured, can still perform basic functions. How long a person can live with liver failure depends on the reversibility of the injury and the severity of the injury. This can range from days to several months. Liver transplantation can be curative, in some cases. ...Read more
Maybe: I'm very sorry that you lost your sister at such a young age. The answer to your question depends upon what caused your sister's liver failure. Her doctors would know whether this has any potential to affect you. You have a right to ask them if the cause of her liver failure was genetic. ...Read more
A condition characterized by failure of the liver to perform its functions, which are vital for life. Liver has many functions: cleaning the body of toxins, processing food, producing proteins and blood clotting factors, modulating blood glucose. Failure can be seen: bleeding, fluid accumulation, yellow skin, no energy, confusion. Liver failure occurs acutely (rapid) ...Read more
Bilirubin is the potentially toxic product of heme metabolism. It is formed by breakdown of heme present in hemoglobin, myoglobin, cytochromes, catalase, peroxidase and tryptophan pyrrolase. Eighty percent of the daily bilirubin production comes from hemoglobin. It requires conversion to a water-soluble form before elimination from the body by ...Read more