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Doctor insights on: Bilirubin Liver Failure

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Can high levels of bilirubin alone cause liver failure in a metastic liver cancer pt?

Can high levels of bilirubin alone cause liver failure in a metastic liver cancer pt?

Let's reframe the ?: The issue isn't the amount of bilirubin causing problems with the liver. The liver is likely infiltrated with tumor mets and therefore is not able to process bilirubin. The elevated bilirubin can have multiple causes but is a symptom of the liver failure rather than the cause. It can also be a symptom of obstruction of the biliary system in the liver by tumor or simply inactivity (cholestasis). ...Read more

Dr. Julie Abbott
2 doctors shared insights

Liver (Definition)

This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more


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Is high bilirubin a sign of liver failure?

Is high bilirubin a sign of liver failure?

Not necessarily: How high is the bilirubin and what type is it? High bilirubin can be due to bile duct obstruction, genetic causes, and also liver injury. All lab results need to be interpreted in the clinical context and the doctor who ordered the test is usually in the best position to do that. ...Read more

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Mcrc patient. Bilirubin rising as 12 19 12 32 51 74 85 Other liver tests are okay.will this lead to liver failure? No blockage seen

Mcrc patient. Bilirubin rising as

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51
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85

Other liver tests are okay.will this lead to liver failure? No blockage seen

Are you on Stivarga?: I found "Interrupt and then reduce or discontinue STIVARGA for hepatotoxicity as manifested by elevated liver function tests ...." and "... Monitor liver function tests weekly in patients experiencing elevated liver function tests until improvement to less than 3 times the upper limit of normal (ULN) or baseline values." You are above 3 times normal. Reduce or stop. Call your PCP re liver failure ...Read more

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Taken paracetomol 2g/day for 15 day upto 31.08.16.LFT on 19.09.16- bilirubin 0.5, SGOT 28,SGPT 51. Skin, eyes yellow & drowsy. Is it liver failure?

Taken paracetomol 2g/day for 15 day upto 31.08.16.LFT on 19.09.16- bilirubin 0.5, SGOT 28,SGPT 51. Skin, eyes yellow & drowsy. Is it liver failure?

No: Why are you taking paracetamol? Who ordered the lab tests? It would be prudent to discuss it with the doctor who ordered the tests. The "yellow' color of your eyes and skin is not due to liver disease, or jaundice.
For good health — Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Drink enough water daily so that your urine is mostly colorless.
Practice safe sex. ...Read more

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Total protein 7.7, Albumin 4.0, total bilirubin 0.4, ALP 131 (norm up to 116), ALT 55, AST 24. Concern for liver failure? Doc said nothing onhigh ALP

Total protein 7.7, Albumin 4.0, total bilirubin 0.4, ALP 131 (norm up to 116), ALT 55, AST 24. Concern for liver failure? Doc said nothing onhigh ALP

Alkaline phosphatase: It is difficult to interpret labs without knowing the medical setting under which they were drawn. Having said that, there are many things besides liver issues that can cause a slight increase of alkaline phosphatase. I would recommend talking to your doctor about this, and perhaps having a repeat blood draw in 1 to 2 months. Good luck. ...Read more

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My prothrombin time is INR 1.3 with normal aptt and platelet counts. Do I have liver failure? Normal ast, alt, alp and bilirubin. Burns right stomach

My prothrombin time is INR 1.3 with normal aptt and platelet counts. Do I have liver failure? Normal ast, alt, alp and bilirubin. Burns right stomach

Probably not: The slight elevation in the INR with normal labs for the rest of your liver functions suggests you don't have liver disease. The burning could be coming from an ulcer, or gastritis, or esophagitis. The body doesn't do a good job of localizing pain coming from the internal organs, so where you feel the pain may not be where it is. Follow up with your doctor to check out different causes. ...Read more

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Can hepatitis b cause liver failure?

Can hepatitis b cause liver failure?

Yes: Chronic hepatitis b can cause the liver to develop severe scarring from the longstanding inflammation the virus causes. The scarring, commonly referred to as cirrhosis, can be progressive such that more and liver function is lost to scarring. Eventually there are too few healthy liver cells to remove toxins from the body and liver failure happens, usually over a period of years. ...Read more

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Symptoms of liver failure?

Symptoms of liver failure?

Jaundice: Liver failure is usually do to some inflammatory process damaging the liver. Jaundice, nausea, vomitting, itching, bruising and bleeding are associated woth liver failire. ...Read more

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Can you die from liver failure?

Can you die from liver failure?

Definitely: You need your liver to live. It's the master biochemist in the body; makes proteins, bile, clotting factors, detoxifies drugs, chemicals, poisons, etc. Death from liver failure usually is not pretty; can be associated with abdominal fluid collection (ascites), which can get infected, altered mental status (with or without coma), weight loss, bleeding from varicose veins of esophagus stomach, etc. ...Read more

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What are some signs of liver failure?

What are some signs of liver failure?

Many: Confusion, skin color and the eyes turn yellow, there is a change to very dark urine(coca cola color) then belly might enlarge with fluid, the legs can begin to swell. If any of these are suspected please see your doctor immediately. ...Read more

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What are the symptoms of liver failure?

What are the symptoms of liver failure?

Many: Progressive weakness, loss of weight, changing mental status, fluid retention in the belly and legs, yellow of the eyes, vomit of blood or in stool.... Any or all of these can be present. ...Read more

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What happens when you have liver failure?

What happens when you have liver failure?

Bad things: By definition the liver is failing to work correctly. This may include jaundice, bleeding, ascites, confusion and possibly death. ...Read more

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What happens when you have liver. Failure?

What happens when you have liver. Failure?

Bad things happen: The liver is necessary for life, so if the liver fails, bad things happen. Toxic chemicals that are natural byproducts of the human body start to build up (such as ammonia) and damage many organs. Necessary proteins that a normal liver makes, are no longer made (such as Albumin and the clotting proteins). Without albumin, a major protein in blood plasma, a person will swell up with fluid.... ...Read more

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Are there easily recognizable signs of liver failure?

Jaundice: Liver failure, depending on how rapidly it occurs, will cause fluid in the abdomen(ascites), leg swelling, and a distinct yellow/bronze discoloration of the skin called jaundice. ...Read more

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Can malaria lead to liver failure?

Can malaria lead to liver failure?

Rarely: It is rare to have liver damage secondary to malaria and when it happens it is the result of a coexisting liver condition such as viral hepatitis and chronic liver disease. Malaria caused by plasmodium falciparum may cause liver failure esp if it s is recurrent. As you will see the life cycle of malaria involves liver, however again the damage is rare. ...Read more

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How fast do you lose weight on liver failure?

Can be quick: Depends on how severe your liver failure is and whether you are able maintain any caloric intake. ...Read more

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Hallucinations from liver failure, what to do?

Hallucinations from liver failure, what to do?

Talk to doc: I am sorry to hear the trouble you are having. Hallucinations due to liver failure are most likely to be a direct effect of abnormal levels of chemicals that the liver normally clears from the blood. Please discuss this asap with your liver doctor or some one covering for him/her. ...Read more

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My gamma GT was 331 is that near liver failure?

My gamma GT was 331 is that near liver failure?

Depends: Your liver is a critically important organ for long term health. Protect it. Okay to check in with your doc about tests to evaluate for gallstones and other correctable problems. Alcohol is toxic to the liver. If you are addicted to alcohol, get treatment. Be well. ...Read more

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Would liver failure affect your breathing rate?

Would liver failure affect your breathing rate?

Yes: I'm several ways. In liver failure, fluid can accumulate in the abdomen (ascites) that can push up on the diaphragm & cause trouble bleeding. There is also a very specific syndrome, hepatopulmonary syndrome, that can cause shortness of breath. ...Read more

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Which is worse -- hepatotoxicity vs liver failure?

Semantics: Hepatotoxicity is exposure of the liver to something that makes it sick. This may be acute, subacute, or chronic. Liver failure, similarly may be acute, chronic and compensated, or chronic and decompensated. A failing liver implies significant loss of liver function. Both scenarios should be avoided. In either case, stay away from alcohol, and ask your doctor for lifestyle, diet, rx advice. ...Read more

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Is it possible to suffer from acute liver failure at 17?

Is it possible to suffer from acute liver failure at 17?

Absolutely, yes!: It is fortunately less common these days, but acute hepatitis a/b can cause liver failure, and those of toxic side effects of medications especially chemo/biologic agents. Drug overdose such as tylenol (acetaminophen) can cause fulminant liver failure and aweful death. There are other causes, but less common. If you have trouble, please consult your doc. Good luck. ...Read more

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How long after your kidney and liver failure can you live?

How long after your kidney and liver failure can you live?

Not long: If these organs truly stopped working completely, survival would be short 1-2 weeks at most. ...Read more

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What are the signs of liver failure because your an alcoholic?

Alcohol liver dz.: Sxs of liver disease due to alcoholism may include: nausea, vomiting, drop in appetite, weight loss, abdominal pain & bloating, yellowing of skin & eyes, itching, numbness of legs/ feet, memory problems, cognitive difficulties, depression, fatigue & thirst. If you have these sxs — please get immediate medical help. You can work with an addiction medicine specialist & alcoholics anonymous. ...Read more

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What's the average life expectancy for someone with liver failure?

What's the average life expectancy for someone with liver failure?

Depends: There are 2 main categories of liver failure-- compensated or uncompensated. Compensated means that the liver while profoundly injured, can still perform basic functions. How long a person can live with liver failure depends on the reversibility of the injury and the severity of the injury. This can range from days to several months. Liver transplantation can be curative, in some cases. ...Read more

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My sister died at 20 from liver failure. Should i also get tested?

Maybe: I'm very sorry that you lost your sister at such a young age. The answer to your question depends upon what caused your sister's liver failure. Her doctors would know whether this has any potential to affect you. You have a right to ask them if the cause of her liver failure was genetic. ...Read more

Dr. Robert Rahimi
686 doctors shared insights

Liver Failure (Definition)

A condition characterized by failure of the liver to perform its functions, which are vital for life. Liver has many functions: cleaning the body of toxins, processing food, producing proteins and blood clotting factors, modulating blood glucose. Failure can be seen: bleeding, fluid accumulation, yellow skin, no energy, confusion. Liver failure occurs acutely (rapid) ...Read more


Bilirubin (Definition)

Bilirubin is the potentially toxic product of heme metabolism. It is formed by breakdown of heme present in hemoglobin, myoglobin, cytochromes, catalase, peroxidase and tryptophan pyrrolase. Eighty percent of the daily bilirubin production comes from hemoglobin. It requires conversion to a water-soluble form before elimination from the body by ...Read more