Doctor insights on:
Bilirubin Gilberts Syndrome
Does bilirubin and or gilberts syndrome really protect against heart disease or coronary blockage? Or is this false?
Says who?: It is possible to do a bad scientific study and find any link whatsoever. I'd cite cell phone and brain tumors. The most recent study I could find was the 13 year old study with barely significant numbers from an obscure institution and it makes no sense. Any time you hear about "antioxidants", put your hand over your wallet. Http://www. Ncbi. Nlm. Nih. Gov/pubmed/11849670 ...Read more
Bilirubin is the potentially toxic product of heme metabolism. It is formed by breakdown of heme present in hemoglobin, myoglobin, cytochromes, catalase, peroxidase and tryptophan pyrrolase. Eighty percent of the daily bilirubin production comes from hemoglobin. It requires conversion to a water-soluble form before elimination from the body by ...Read more
Safe: The only danger in "gilbert's" is that someone will misunderstand / overdiagnose / overtreat. Very rarely, gilbert's people run into trouble with a few medications; your physician will be aware of this. It should be called "gilbert's non-disease". ...Read more
What is the cause of elevated bilirubin in young man, more than 2 years? Bilirubin is 31 (norm <17)no gilbert syndrome
Many possible causes: ... ranging from problems with the gallbladder or bile duct to liver problems to problems with metabolism. If you know that Gilbert syndrome is not present, you must have seen a physician about this in the past. If a diagnosis still has not been made, I would ask to see a hepatologist for more definitive testing. Good luck. ...Read more
I have Gilberts syndrome and my bilirubin is 2.5. I have red patches on the tops of my hands and it itches. Is the from GS?
No: The rash is not due to Gilbert's. ...Read more
Doctor found elevated bilirubin 32.0 in blood, diagnosed gilberts syndrome without further investigating isn't it true that elevated bilirubin can he?
Gilbert's: Bili can be elevated for a large number of reasons, but elevations of unconjugated bili without other findings and a long Hx of mild elevations of unconj bili can likely be attributed to Glilberts. The presence of other comorbid conditions or symptoms negates this. ...Read more
2 tests done in past few months. Total Bilirubin 21 umol/L N < 25 // 1st test showed 25 umol/L. Suggested Gilberts, is 21 high?
Bilirubin high?: F age? : 2 tests done in past few months. Total Bilirubin 21 umol/L N < 25 // 1st test showed 25 umol/L. Suggested Gilberts, is 21 high? ANS: No-if the normal is <25 then 21 is <25 and therefore normal. But discuss with Drs that ordered the test. Gilbert's is inherited problem with bilirubin metabolism of no consequent-mostly. Discuss with your Dr. Go to uptodate. Com for more information. ...Read more
Indirect bilirubin 1.6, direct 0.3. Direct is only 0.1 above normal. Dr. Said gilbert's. Abdominal u/s normal. Gilberts?
Yes: Undoubtedly. And the elevations are very minimal. I'm sure this will give you minimal or no problems. ...Read more
Is gilberts disease present at birth or can you develop later in life? How high can bilirubin get? Mine was 1.99. Rdw was 14.4 is this a sign of gs?
Gilbert's syndrome..: Is a disorder caused by an enzyme deficiency. The enzyme is a glucuronyltransferase responsible for conjugating bilirubin (a breakdown product of heme generated with red blood cell turnover), making it water soluble and more readily cleared. The disorder is inherited, but is usually harmless. Patients may have a yellow hue to the skin (jaundice) or whites of the eyes (icterus). Illness may worsen. ...Read more
Can you just all the sudden develop gilberts? My bilirubin has been middle elevated for over a year. Alt and AST been ele for 10mth last 2 mth good
Bilirubin total 2.5, direct 0.4, indirect 2.1 family dr says gilberts disease. Ultrasound good. 2nd opinion? Do mrcp scan? Not needed? Some nausea.
Gilbert's Disease: It sounds like you do not need a second opinion. You have gilbert's disease and your liver is healthy. ...Read more
Blood work done 5 years ago, my reticulyte count was at 0.6 on a scale of 0.5-1.5. Everything else was normal including LDH, rbc, hemoglobin and haptoglobin. I have been told I have gilberts bc my indirect bilirubin is elevated when fasting. Normal?
Sounds like Gilbert: It is very common and a non-problem. Gilbert folks who fast for a day or two get a little deeper jaundice that you can see looking at the whites of the eyes in direct sunlight. Stop worrying m, think about trying this and best wishes. ...Read more
Can gilberts disease cause high ALT 78 and AST 50 and bilirubin 1.2? Diagnosed with fatty liver in july. Had us done in jan it showed little fat.
Will milk thistle also help bilirubin? It has improved my ALT and AST to normal but my bili is not. Could it be high constant with Gilberts high a yr
Sort it out: I understand that you were found to have fatty liver, had high transaminases that are now down. Fatty liver is prone to heal itself especially if you get into fitness even a little bit. Milk thistle has failed most controlled studies though it does reduce toxicity of some drugs. If the bili is unconjugated and goes up if you miss a few meals, Gilbert's is likely. It's very common. ...Read more
Had blood test, total bilirubin was 42 umol, direct was 12 umol, after period of sickness. Went down to 5 umol week later. Doc said gilberts. Correct?
Gilbert's syndrome: You likely have gilbert's syndrome, which is the most common hereditary cause of increased unconjugated (indirect) bilirubin due to reduced activity of the enzyme glucuronyltransferase. It is found in 5-10% of people and normally has no serious consequences. Mild jaundice may appear under conditions of exertion, stress, fasting, and infections, but the condition is usually asymptomatic. ...Read more
My lab results indicated that my bilirubin level is 1.78 mg/dl and I had my hepatitis test and it was negative. Could it be jaundice or gilberts syndr?
Find cause: If your eyes are yellow and your bilirubin is up then you are jaundiced. Folks with gilbert's non-disease get a bit jaundiced if they miss a few meals; if indirect bilirubin has been up before & all else is okay you've probably got gilbert's. Trust you are not hemolyzing (cbc & smear normal) and nothing else points to illness. ...Read more
This appears to: Be your question from yesterday (one of a number). Please remember that if one doctor provides a response, that it will not prevent other doctors from seeing your question and responding. In other words, duplication will not benefit you. ...Read more
What to do if I have gilbert's syndrome with severe jaundice like total bilirubin 5.5 since 5 years.?
That's high: Get re-evaluated. You may have something more than just Gilbert's. ...Read more
Can a person with Gilbert's Syndrome still drink alcohol (1-2 drinks) per day or is it dangerous since Bilirubin is already elevated?
Why would gilbert's syndrome not be diagnosis until middle age if genetic? No history of elevated bilirubin prior to 6 mos ago; other lfts were elevated, now ok.
Dx of exclusion: Gilbert’s syndrome is due to deficiency of an enzyme that helps to excrete bilirubin. It is usually diagnosed between the ages of 15 and 30 years. Patients with gilbert’s syndrome are prone to develop jaundice from time to time. The risk increases with fasting, dehydration, repeated and profuse vomiting, infections, exertion and stress and after a surgery. If uncertain, specific tests can be done. ...Read more
Can I be diagnosed with Gilbert's syndrome only based on my blood bilirubin levels although my 1& 2 UGT1A1 gene analysis came normal (no mutations)?
PossibleOtherVariant: Although your 1&2 UGT1A1 Gene analysis is normal. This variant account for 50%of alleles in many populations. However several allallelic polymorphic variants of this region occur. The most common of which results from adding another dinucleotide repeat TA to the promotor region resulting in A (TA7)AA. So there are other variants in people from south east asia, East Asians and pacific islanders ...Read more
Sometimes my indirect bilirubin is slightly elevated and sometimes it's normal. Dr said it was gilbert's... Does this sound right?
Gilbert's: Yes, that is the proper pattern. You should have no symptoms other than occasional slight jaundice noticeable mostly in the eyes. It does not signify any actual liver disease. Do not worry. Hope that helps. ...Read more
Indirect bilirubin 1.2-1.6 and direct 0.2-0.4 when fasting, when I eat, it goes down to normal being around 1.0 and 0.1 respectively. Dr said Gilbert?
Gilbert's: It is most likly Gibert's but should look for hemolysis ...Read more
Can gilbert's also present with mildly elevated direct bilirubin (0.4-0.7). with elevated total (1.4-2.2) Mostly indirect still some direct elevation?
Not from Gilbert's: Gilbert's syndrome causes a deficiency in the enzyme that converts indirect bilirubin to direct bilirubin. In other words, the only issue is that indirect bilirubin is converted to direct bilirubin more slowly. People with Gilbert's are not unhealthy from it and are not considered to have a "disease." If direct bilirubin is elevated, something else is going on. ...Read more
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