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Doctor insights on: Bilirubin Gilberts Syndrome

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Does bilirubin and or gilberts syndrome really protect against heart disease or coronary blockage? Or is this false?

Does bilirubin and or gilberts syndrome really protect against heart disease or coronary blockage? Or is this false?

Says who?: It is possible to do a bad scientific study and find any link whatsoever. I'd cite cell phone and brain tumors. The most recent study I could find was the 13 year old study with barely significant numbers from an obscure institution and it makes no sense. Any time you hear about "antioxidants", put your hand over your wallet. Http://www. Ncbi. Nlm. Nih. Gov/pubmed/11849670 ...Read more

Bilirubin (Definition)

Bilirubin is the potentially toxic product of heme metabolism. It is formed by breakdown of heme present in hemoglobin, myoglobin, cytochromes, catalase, peroxidase and tryptophan pyrrolase. Eighty percent of the daily bilirubin production comes from hemoglobin. It requires conversion to a water-soluble form before elimination from the body by ...Read more


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Bilirubin level of 80 to 110 due to gilbert syndrome is dangerous or otherwise. Thanks?

Safe: The only danger in "gilbert's" is that someone will misunderstand / overdiagnose / overtreat. Very rarely, gilbert's people run into trouble with a few medications; your physician will be aware of this. It should be called "gilbert's non-disease". ...Read more

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What is the cause of elevated bilirubin in young man, more than 2 years? Bilirubin is 31 (norm <17)no gilbert syndrome

What is the cause of elevated bilirubin in young man, more than 2 years? Bilirubin is 31 (norm <17)no gilbert syndrome

Many possible causes: ... ranging from problems with the gallbladder or bile duct to liver problems to problems with metabolism. If you know that Gilbert syndrome is not present, you must have seen a physician about this in the past. If a diagnosis still has not been made, I would ask to see a hepatologist for more definitive testing. Good luck. ...Read more

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Young mans bilirubin was 45 then it lowered with liver drugs and when hit cut drugs it elevated? Is it gilberts syndrome?

Interesting.: I am not sure I understand the question or the units properly. What units for the bilirubin - what liver drugs? Please resubmit complete question as we will not be able to see this question when your new one comes through. ...Read more

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Doctor found elevated bilirubin 32.0 in blood, diagnosed gilberts syndrome without further investigating isn't it true that elevated bilirubin can he?

Gilbert's: Bili can be elevated for a large number of reasons, but elevations of unconjugated bili without other findings and a long Hx of mild elevations of unconj bili can likely be attributed to Glilberts. The presence of other comorbid conditions or symptoms negates this. ...Read more

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2 tests done in past few months. Total Bilirubin 21 umol/L N < 25 // 1st test showed 25 umol/L. Suggested Gilberts, is 21 high?

Bilirubin high?: F age? : 2 tests done in past few months. Total Bilirubin 21 umol/L N < 25 // 1st test showed 25 umol/L. Suggested Gilberts, is 21 high? ANS: No-if the normal is <25 then 21 is <25 and therefore normal. But discuss with Drs that ordered the test. Gilbert's is inherited problem with bilirubin metabolism of no consequent-mostly. Discuss with your Dr. Go to uptodate. Com for more information. ...Read more

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Indirect bilirubin 1.6, direct 0.3. Direct is only 0.1 above normal. Dr. Said gilbert's. Abdominal u/s normal. Gilberts?

Indirect bilirubin 1.6, direct 0.3. Direct is only 0.1 above normal. Dr. Said gilbert's. Abdominal u/s normal. Gilberts?

Yes: Undoubtedly. And the elevations are very minimal. I'm sure this will give you minimal or no problems. ...Read more

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Is gilberts disease present at birth or can you develop later in life? How high can bilirubin get? Mine was 1.99. Rdw was 14.4 is this a sign of gs?

Gilbert's syndrome..: Is a disorder caused by an enzyme deficiency. The enzyme is a glucuronyltransferase responsible for conjugating bilirubin (a breakdown product of heme generated with red blood cell turnover), making it water soluble and more readily cleared. The disorder is inherited, but is usually harmless. Patients may have a yellow hue to the skin (jaundice) or whites of the eyes (icterus). Illness may worsen. ...Read more

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Can you just all the sudden develop gilberts? My bilirubin has been middle elevated for over a year. Alt and AST been ele for 10mth last 2 mth good

Can you just all the sudden develop gilberts? My bilirubin has been middle elevated for over a year. Alt and AST been ele for 10mth last 2 mth good

Congenital: Gilbert's syndrome is a congenital, life long condition that might get worse in certain condition such as infections or dehydration and may cause jaundice and or fatigue. Otherwise, benign condition with no need for specific treatment. ...Read more

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Blood work done 5 years ago, my reticulyte count was at 0.6 on a scale of 0.5-1.5. Everything else was normal including LDH, rbc, hemoglobin and haptoglobin. I have been told I have gilberts bc my indirect bilirubin is elevated when fasting. Normal?

Blood work done 5 years ago, my reticulyte count was at 0.6 on a scale of 0.5-1.5. Everything else was normal including LDH, rbc, hemoglobin and haptoglobin. I have been told I have gilberts bc my indirect bilirubin is elevated when fasting. Normal?

Sounds like Gilbert: It is very common and a non-problem. Gilbert folks who fast for a day or two get a little deeper jaundice that you can see looking at the whites of the eyes in direct sunlight. Stop worrying m, think about trying this and best wishes. ...Read more

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Can gilberts disease cause high ALT 78 and AST 50 and bilirubin 1.2? Diagnosed with fatty liver in july. Had us done in jan it showed little fat.

Can gilberts disease cause high ALT 78 and AST 50 and bilirubin 1.2? Diagnosed with fatty liver in july. Had us done in jan it showed little fat.

Not usually: Gilbert's causes a "cosmetic" abnormality in bilirubin (bile pigment) metabolism. Does not cause changes on ast, alt-that reflects mild inflammation of liver cells. Could be due to overweight, needs, alcohol, infection, immune inflammation, other. ...Read more

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Will milk thistle also help bilirubin? It has improved my ALT and AST to normal but my bili is not. Could it be high constant with Gilberts high a yr

Sort it out: I understand that you were found to have fatty liver, had high transaminases that are now down. Fatty liver is prone to heal itself especially if you get into fitness even a little bit. Milk thistle has failed most controlled studies though it does reduce toxicity of some drugs. If the bili is unconjugated and goes up if you miss a few meals, Gilbert's is likely. It's very common. ...Read more

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Had blood test, total bilirubin was 42 umol, direct was 12 umol, after period of sickness. Went down to 5 umol week later. Doc said gilberts. Correct?

Had blood test, total bilirubin was 42 umol, direct was 12 umol, after period of sickness. Went down to 5 umol week later. Doc said gilberts. Correct?

Gilbert's syndrome: You likely have gilbert's syndrome, which is the most common hereditary cause of increased unconjugated (indirect) bilirubin due to reduced activity of the enzyme glucuronyltransferase. It is found in 5-10% of people and normally has no serious consequences. Mild jaundice may appear under conditions of exertion, stress, fasting, and infections, but the condition is usually asymptomatic. ...Read more

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My lab results indicated that my bilirubin level is 1.78 mg/dl and I had my hepatitis test and it was negative. Could it be jaundice or gilberts syndr?

Find cause: If your eyes are yellow and your bilirubin is up then you are jaundiced. Folks with gilbert's non-disease get a bit jaundiced if they miss a few meals; if indirect bilirubin has been up before & all else is okay you've probably got gilbert's. Trust you are not hemolyzing (cbc & smear normal) and nothing else points to illness. ...Read more

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How severe are bilirubin counts of people with gilbert's syndrome?

Variable: Under baseline conditions the bilirubin is less than 3 mg/dl. However some drugs can raise it higher. ...Read more

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Normal lipids, fasting bilirubin 1.5 Nonfasting bilirubin 1. Do I have Gilbert's syndrome?

This appears to: Be your question from yesterday (one of a number). Please remember that if one doctor provides a response, that it will not prevent other doctors from seeing your question and responding. In other words, duplication will not benefit you. ...Read more

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Can a person with Gilbert's Syndrome still drink alcohol (1-2 drinks) per day or is it dangerous since Bilirubin is already elevated?

Can a person with Gilbert's Syndrome still drink alcohol (1-2 drinks) per day or is it dangerous since Bilirubin is already elevated?

Gilbert's syndrome: This is harmless. But excess alcohol can poison anyone's liver. I do not know what size drink you are talking about. 2 Oz a day is max recommended for most but less is better. Any Alcoholics in your family? Beware then due to this but Gilbert's is no worries. ...Read more

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Why would gilbert's syndrome not be diagnosis until middle age if genetic? No history of elevated bilirubin prior to 6 mos ago; other lfts were elevated, now ok.

Why would gilbert's syndrome not be diagnosis until middle age if genetic? No history of elevated bilirubin prior to 6 mos ago; other lfts were elevated, now ok.

Dx of exclusion: Gilbert’s syndrome is due to deficiency of an enzyme that helps to excrete bilirubin. It is usually diagnosed between the ages of 15 and 30 years. Patients with gilbert’s syndrome are prone to develop jaundice from time to time. The risk increases with fasting, dehydration, repeated and profuse vomiting, infections, exertion and stress and after a surgery. If uncertain, specific tests can be done. ...Read more

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Can I be diagnosed with Gilbert's syndrome only based on my blood bilirubin levels although my 1& 2 UGT1A1 gene analysis came normal (no mutations)?

Can I be diagnosed with Gilbert's syndrome only based on my blood bilirubin levels although my 1& 2 UGT1A1 gene analysis came normal (no mutations)?

PossibleOtherVariant: Although your 1&2 UGT1A1 Gene analysis is normal. This variant account for 50%of alleles in many populations. However several allallelic polymorphic variants of this region occur. The most common of which results from adding another dinucleotide repeat TA to the promotor region resulting in A (TA7)AA. So there are other variants in people from south east asia, East Asians and pacific islanders ...Read more

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Bilirubin total high 3.5, normal liver function test, negative Gilbert's syndrome, bili direct normal 0.2, normal cbc, what could cause mild bili?

Hemolyzing: You may simply have Gilbert's despite "testing negative for it". Or you may be hemolyzing. It might be worth checking your reticulocyte count; this is often up even without your being anemic in folks who run a high bilirubin like yourself. ...Read more

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Bilirubin 1.6, all other lft normal, normal reticulyte. My dr said gilbert's.. Do you agree?

I'll bet so: I'm trusting this is indirect bilirubin. One way to be sure is to think back -- if there's ever been a time when you were sick and didn't eat for a few days, or did a religious fast for a few days, Gilbert folks get a bit jaundiced. It's a non-problem. Best wishes. ...Read more

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Sometimes my indirect bilirubin is slightly elevated and sometimes it's normal. Dr said it was gilbert's... Does this sound right?

Sometimes my indirect bilirubin is slightly elevated and sometimes it's normal. Dr said it was gilbert's... Does this sound right?

Gilbert's: Yes, that is the proper pattern. You should have no symptoms other than occasional slight jaundice noticeable mostly in the eyes. It does not signify any actual liver disease. Do not worry. Hope that helps. ...Read more

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Can gilbert's also present with mildly elevated direct bilirubin (0.4-0.7). with elevated total (1.4-2.2) Mostly indirect still some direct elevation?

Not from Gilbert's: Gilbert's syndrome causes a deficiency in the enzyme that converts indirect bilirubin to direct bilirubin. In other words, the only issue is that indirect bilirubin is converted to direct bilirubin more slowly. People with Gilbert's are not unhealthy from it and are not considered to have a "disease." If direct bilirubin is elevated, something else is going on. ...Read more