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Doctor insights on: Beta2 Glycoprotein I Ab Igm

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Beta-2 glycoprotein i ab, IgM 48 high. What does this mean?

Beta-2 glycoprotein i ab, IgM 48 high. What does this mean?

Blood Clots too much: Beta-2 glycoprotein 1 antibody tests are used to help find the cause of unexplained blood clots (thrombotic episodes) or recurrent miscarriages. Also used to diagnose antiphospholipid syndrome (APS), or to detect the autoantibodies in someone with another autoimmune disorder. Sometimes may be ordered with cardiolipin antibody and lupus anticoagulant testing. IgG, IgM or IgA may be elevated. ...Read more

Dr. Gregory Lanza
811 doctors shared insights

Immunoglobulin M (Definition)

There are 5 classes of immune proteins: igg, iga, igm, ige and igd. Igm fights infection. If you produce too little then infections may occur and you have hypogammaglobulinemia. If you have too much you ...Read more


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Does anticardiolipin IgM (115ug/l) x 3 have any significance when it is rasied on its own? LA Positive but beta glycoprotein & other antibodies neg

Does anticardiolipin IgM (115ug/l) x 3 have any significance when it is rasied on its own?  LA Positive but beta glycoprotein & other antibodies neg

Higher future risk: The cause of an elevated aCL without other diseases is unknown. That said, 50% of people with + lupus anticoagulant have or will have SLE. Presumably, manifestations require the aCL plus another problem - infection, one of a number of drugs, pregnancy, BC pills, etc. The significance is the higher than normal risk in the face of future immunological injury ...Read more

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Please tell me, could a person with a myelin associated glycoprotein antibody, IgM have multiple sclerosis?

Please tell me, could a person with a myelin associated glycoprotein antibody, IgM have multiple sclerosis?

Possible comorbidity: The mag levels do not help confirm multiple sclerosis or even seem to correlate with this disorder, and typically, point toward problems with the peripheral nervous system. You could have ms and another condition, and a neurologist might help with both. Suggest you discuss your test and seek correlations if any. ...Read more

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Do you rule out aps if anticardiolipin antibody and beta 2 glycoprotein (both IgG and igm) are often elevated but in borderline and weakly positive range?

Do you rule out aps if anticardiolipin antibody and beta 2 glycoprotein (both IgG and igm) are often elevated but in borderline and weakly positive range?

See below: There are certain criteria that must be met in order for one to have aps. One of which is that one must have some type of thrombotic event. Antibodies alone do not make the diagnosis. Without knowing full details regarding your case, it is difficult to say whether you do or not. ...Read more

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What does it mean to have a positive IgM p41 ab but IgM p39 ab. and IgM p23 ab. are negative? What causes p41 to be present?

What does it mean to have a positive IgM p41 ab but IgM p39 ab. and IgM p23 ab. are negative? What causes p41 to be present?

Unlikely lyme: P41 is not very specific for Lyme and 1.5 percent of general population may have it likely as protection against getting Lyme that is inherited rather than acquired. The other negative tests also confirm that u do not have it, but Lyme disease is a clinical diagnosis and all factors need to be considered. If you are still having symptoms, work with your doctor to get to the button of the problem ...Read more

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What is hepatitis b core ab IgM test?

What is hepatitis b core ab IgM test?

See below: Presence of IgM hepatitis b core antibody indicates an acute (current) or recent hepatitis b infection. ...Read more

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On ceruplasmin test hep A AB Total reactive ref range U mean? Also Hep A AB (IGM) nonreactive ref range U mean? What am I testing positive for?

On ceruplasmin test hep A AB Total reactive ref range U mean? Also Hep A AB (IGM) nonreactive ref range U mean? What am I testing positive for?

Lab tests: You do not give a value for the ceruloplasm. If you have antibodies to Hepatitis A virus and the IgG is positive and the IgM negative it suggests that you were immunized for hepatitis A or had infection in the past. Why not discuss these values with the doctor who ordered them? ...Read more