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Doctor insights on: Beta Thalassemia Trait Diagnosis

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Can an alpha thalassemia carrier marry a beta thalassemia carrier?

Can an alpha thalassemia carrier marry a beta thalassemia carrier?

Of course you can: A person can marry anyone they like. From a thalassemia perspective, and assuming your Alpha thal trait is in cis, your child has a 50/50 chance of being Alpha thal trait vs. Normal and a 50/50 chance of being beta thal trait vs. Normal. Given there is consideration of inheriting two distinct trait states, it would be prudent to sit with a genetic counselor to understand the implications clearly. ...Read more

Dr. Craig MacArthur
67 doctors shared insights

Beta Thalassemia (Definition)

A genetic blood disorder that limits a person's ability to produce hemoglobin, thus leading to anemia due to an inadequate amount ...Read more


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What is sickle cell beta thalassemia?

What is sickle cell beta thalassemia?

Got both mutations: A person has sickle cell beta thalassemia if he inherited one gene mutation for sickle cell anemia, and also inherited one gene mutation for beta thalassemia. He can have symptoms of sickle cell disease, unlike patients with only sickle cell trait who are generally without symptoms. ...Read more

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Does alpha thalassemia trait have gene therapy available?

Does alpha thalassemia trait have gene therapy available?

No: Alpha thalassemia trait only causes mild anemia, and the person usually has no symptoms. Gene therapy is not available and would not be needed. ...Read more

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Beta thalesemic carrier state...Meaning?

Beta thalesemic carrier state...Meaning?

Genes: To have beta thalessemia, you have to have 2 copies of a particular gene. If you only have 1 copy, you don't have the disease, but you do carry the trait, and can pass it to your children. If your partner also is a carrier of the gene, then there is a 1 in 4 chance that your child will have beta thalessimia. ...Read more

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Is beta thalassemia major andd hb e/beta thalassemia same?

Is beta thalassemia major andd hb e/beta thalassemia same?

Not the same.: Hemoglobin e is found in the asian population frequently and may be seen with thal trait. Thal major is a serious problem requiring much intervention, including transfusions and frequently splenectomy. Your doctor should be your guiding you. Pregnancy needs to be discussed with your doctor. ...Read more

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Are hb s levels elevated with beta thalassemia trait?

Are hb s levels elevated with beta thalassemia trait?

No: With beta thalassemia trait alone, no hemoglobin s should be detected. If hemoglobin s is being detected in addition to beta thalassemia trait then the patient has a form of sickle cell beta thalassemia disease. ...Read more

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What is thalassemia and thalassemia trait?

What is thalassemia and thalassemia trait?

Cooley's Anemia: Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form of hemoglobin, the disorder results in excessive destruction of red blood cells, which leads to anemia. Thalassemia trait is a genetic possibility you pass on to your offspring. The most important reason for discovering if you carry the thalassemia trait is this: if two people who each. ...Read more

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Sickle trait is a recessive gene?

Sickle trait is a recessive gene?

basically yes: The mutation that causes sickle cell disease is a recessive mutation in that you need two copies of the changed gene to have the disease (or one copy plus another mutation on the other gene like beta thalassemia, hemoglobin c, hemoglobin e, etc). If you only have one copy, you have sickle cell trait. ...Read more

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Can a person wtih alpha thalassemia trait donate blood?

Can a person wtih alpha thalassemia trait donate blood?

Maybe: A person with Alpha thalassemia trait may be not anemic or mildly anemic. If he is not anemic, he can be a blood donor. However, since he has a more difficult time making hemoglobin (to make new red blood cells), he may not wish to be a blood donor. ...Read more

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What is trait thalassemia?

What is trait thalassemia?

Ok: Thal trait is different from thal major--the trait has one chromosome for this disease and the full disease means each parent gave the trait and that the child got a thalassemia gene from each parent which can cause thal major, a very serious and transfusion requiring process. There are different types of thalassemia--some more concerning than others. Please ask your doctor. ...Read more

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Is sickle-cell anemia a recessive, sex-linked trait?

Is sickle-cell anemia a recessive, sex-linked trait?

Yes and no: Sickle cell disease is recessive; you need to inherit a sickle gene from both parents to get the disease. It is not x-linked, however; if it were it would affect only boys. Boys and girls are equally affected by sickle cell disease. ...Read more

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What is the alpha thalassemia trait?

What is the alpha thalassemia trait?

Inherited defect: Our regular hemoglobin is composed of Alpha and beta chains that come together to form working hemaglobin. Alpha thalassemia trait occurs when a person inherits a defective Alpha chain gene from one parent & a normal Alpha chain gene from the other. This causes some reduction in Alpha chain production with resulting mild anemia. ...Read more

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What is beta thalassemia?

What is beta thalassemia?

Beta thalassemia: is a genetic defect of impaired hemoglobin production, resulting in a varying degree of anemia. ...Read more

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Is alpha thalassemia trait the same thing as alpha thalassemia?

Not quite: Normal people have 4 Alpha globulin genes. Mutations in 1, 2, 3, or all 4 of the genes cause the 4 levels of Alpha thalassemia. One mutation = silent carrier (no symptoms), 2 mutat. = Alpha trait (mild anemia), 3 mutat. = HGB h disease (anemia sometimes needing transfusions), 4 mutat. = bart's disease (fatal before birth in almost all cases; lifelong transfusions needed to survive if born alive). ...Read more

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What is sickle cell trait and anemia?

What is sickle cell trait and anemia?

Genes: Sickle cell anemia occurs when someone has 2 sickle cell genes. Normal hemoglobin (hb) genes code for hb a. A sickle cell gene codes for hb s. Having 1 hb a gene & 1 hb s gene leads to sickle trait. This will have no symptoms, but has some health consequences. 2 genes for hb s leads to sickle cell anemia. To make things more complicated, there are other abnormal hb genes that can cause problems. ...Read more

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Help docs, is hemoglobin AC a sickle cell trait?

Help docs, is hemoglobin AC a sickle cell trait?

No: Hgb AC is a heterozygous genetic state that is not sickle cell trait ( Hgb AS). Patient's with Hgb AC are clinically well with at worst mild asymptomatic anemia (most are not anemic). Individuals with Hgb AC can have children with Hgb SC (a type of severe sickle cell hemoglobinopathy) if their partner has either sickle cell trait (25% chance) or sickle cell disease (50% chance) ...Read more

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Do beta thalassemia and sickle cell anemia always reduce life expectancy?

Do beta thalassemia and sickle cell anemia always reduce life expectancy?

Not if just 1 trait: Having either beta thalassemia trait or sickle cell trait is a mild condition and should not cause symptoms to the point of making a person frequently ill nor shortening life expectancy. Having beta thalassemia major or sickle cell disease, or both sickle cell trait and beta thalassemia trait, usually causes severe enough chronic disease symptoms to shorten lifespan an uncertain amount. ...Read more

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How to differentiate between alpha thalassaemia trait and hb h disease without a genetic test?

How to differentiate between alpha thalassaemia trait and hb h disease without a genetic test?

Electrophoresis, but: Levels of hemoglobin h and hemoglobin barts should make the distinction straightforward though there may be modifying genes that could make interpretation. The real question is the implications in planning your family and for this perhaps you would like to have genetic testing done. Any hematologist would probably enjoy helping you out. Good luck. ...Read more

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Is there a treatment available for people with sickle cell trait and alpha thalassemia?

Is there a treatment available for people with sickle cell trait and alpha thalassemia?

Yes: Hematologists (blood specialists) evaluate persons with both sickle cell trait and Alpha thalassemia disease. The sickling should not be a problem, because the person is only sickle trait, and Alpha thal. Mutations seem to lessen the tendency of blood cells to sickle from the sickle cell mutation. Persons with both sickle trait and Alpha thal. Trait probably won't have symptoms needing treatment. ...Read more

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Dr. Michael Engel
278 doctors shared insights

Thalassemia (Definition)

An inherited condition characterized by severe anemia (a deficiency of red blood cells), ...Read more