Doctor insights on:
Beta Thalassemia In Children
I have thalassemia minor (beta thalassemia) and my fiance also has traits of beta thalassemia... Can we have normal children?
Find out: Your fiance needs to be tested as well and you both need to sit down with a genetic counselor in any case. It's not just "can we have normal children?" the real question, "do we want to knowingly run the risk of 1 out of 4 of each of our children being born with a god-awful case of beta-thal major? What are our options? Are they acceptable to us?" this is a very grave matter. ...Read more
If a 2 yrs old e beta thalassemia baby take Hydroxyurea then will it affect her fertility (ability to have children)? Pls advice...
Unknown: No the baba HUG trial demosntrated clinical improvment to patients with primarly sickle cell disease (but also thalasemia) with the use of hydrea (hydroxyurea). There have been no reproted long term consequences of hydrea (hydroxyurea) therapy in young children. Hydrea (hydroxyurea) is a teratogen and should not be given to pregnant women, but thus far has not been reported as a cause female infertility, only male. ...Read more
Depends on type...: There are different types of beta thalassemia (minor, intermedia, or major for example) that have much different impacts on a patient's health. Treatment can range from nothing (minor) to requiring frequent blood transfusions, iron chelation therapy or even a bone marrow transplant (major). A hematologist can help with the management of all types. ...Read more
Yes: Thalassemia is one of the most common gene mutations in the world. Overall, an estimated 20-25 million people are carriers (1/300) (about 1/1000 in low-risk peoples, and about 1/30 in high-risk peoples). Low risk: japanese, korean, n. European caucasians, native canadians, native americans. High risk: mediterranean, middle eastern, south asian, south-east Asian (western pacific rim), caribbean. ...Read more
No: I am going to assume you have beta thalassemia minor. This is a minor abnormality that makes you trivially anemic and makes your blood cells look a little odd. If you marry someone else who has this, each of your children had 1/4 chance of having thal major, which is a horrible illness. Heads up. Best wishes. ...Read more
What kind?: Beta thal minor shouldn't be a problem. If you have beta thal major and are asking this question, you should be congratulated on your excellent response to treatment and I hope that you get what you want -- but don't be disapponted if you're asked to remain a civilian. ...Read more
Major or minor?: Beta thal minor is a non-problem; the rate of red cell production is somewhat higher so get plenty of Folic Acid in your diet or supplement. Beta thal major is a very serious illness requiring lifelong close management by a physician; again, the need for Folic Acid and a generally nutritious diet is worth remembering but there's no magical food remedy. Good luck. ...Read more
How to know if someone had thalassemia @ beta thalassemia? What criteria if they had it is dangerous?
I have beta thalassemia and I have hemoglibin d, my fiancee has minor beta thalassemia, is there any problem for our child in future?
I would: Suggest you better directly ask a hematologist or a geneticist they are in position to give you best answer... ...Read more
My husband and I just received news that we both have beta Thalassemia. He is Caucasian and I'm Indian. What are the chances of our child getting this?
Depends: Thalassemia is autosomal recessive. That means that you only get the disease if you have the gene on both of your chromosome pairs. If you and your husband both have the actual disease, there is a 100% chance your children will have it. If you both have trait (one normal and one disease gene), there is a 25% chance they will have it, and a 50% chance they will be a carrier. I have attached a pic. ...Read more
Yes: Beta thalassemia disease is prevented if beta thal carriers do not have children with one another (if they have children together, some children will be normal, some carriers, and some have disease). The other, less desirable way, is to test fetuses during pregnancy and abort the fetuses who have beta thal major. ...Read more
Unrelated: Beta thal is a congenital disease-where there is defect on the beta- globin inside the rbc. The severity of the disease depends on how many b- globin affected. Beta thal major is very debilitating- tansfusion dependent and only transplant can perhaps cure it. Leukemia however is malignancy of the progenitors of the white cells-in bone marrow. Different types of leukemia-acute vs chronic leukemia. ...Read more
Similar but differen:
Alpha and beta thalassemia are distinct and different disorders since they diminish the production of distinct and different globin polypeptide chains and particularly in the homozygous state that has distinct and different consequences. Alpha and Beta Thal minor are similar
Alpha Thal major is not compatable with life and results in miscarriage. Beta Thal major requires prolonged treatments etc. ...Read more
For those who having hb e/beta thalassemia, what food should they eat and what should not they eat?
Thalassemia : This is a genetic hemolytic blood disorders transmitted to you from your parents in your genes & instead of having the normal Hgb A, it becomes abnormal Hgb. There are different types of thalassemia. If both parents are carriers or have the disease then the offspring might get the disease. I hope this helps. Good luck. ...Read more
Genetics: Beta thalassemia is an inherited disorder. A person is born with the disorder. Prevention needs to be practiced by the prospective parents, through testing and genetic counselling by people in families with history of beta thalassemia. ...Read more
Blood transfusions: Beta thalassemia trait patients are non-anemic or mildly anemic, and they do not need treatment. Beta thalassemia intermedia patients have anemia, and sometimes they are severe enough to need occasional transfusions. Beta thalassemia major (cooley's anemia) patients are dependent on lifelong transfusions to survive, and they will eventually suffer from iron overload. ...Read more
Genetic disorder: http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3237252/ "the disorder is characterized by marked clinical variability, ranging from a mild and asymptomatic anaemia to a life-threatening disorder requiring transfusions from infancy. "...."careful tailoring of treatment is required for each patient, and that therapeutic approaches should be re-assessed over-time." not curable. Look at website-. ...Read more
Pediatric Hematolo-: Gists have the expertise to diagnose & treat Hb E/?-thalassaemia, which results from co-inheritance of a?-thalassaemia allele, an alternative form of a gene, from 1 parent and the structural variant Hemoglobin E from the other. They check for co-inheritance of?-thalassemia & polymorphisms, 2 or more alleles at 1 locus, that ^ synthesis of Fetal Hb. These are factors that determine severity. ...Read more
No: With beta thalassemia trait alone, no hemoglobin s should be detected. If hemoglobin s is being detected in addition to beta thalassemia trait then the patient has a form of sickle cell beta thalassemia disease. ...Read more
Anemia symptoms: The symptoms of beta thalassemia major are those of severe anemia, which include weakness, pallor (pale appearance), decreased growth/development, rapid heart rate, exercise intolerance, thickened bones as the marrow enlarges to try to make more blood cells, enlarged spleen, etc... ...Read more
No : The patient with beta thalassemia is anemic and he himself receives blood. ...Read more
Manifestations vary: Hgb e/b-t results from inheritance of a HGB e mutation from one parent and a beta-thalassemia mutation from the other parent. The severity of HGB e/b-t varies from mild to severe. ~50% of individuals who have HGB e/b-t have severe manifestations that resemble thalassemia major. ~50% of individuals who have HGB e/b-t have symptoms similar to thalassemia intermedia. ...Read more
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