Doctor insights on:
Beta Thalassemia Connected To Kidney Disease
Yes: Beta thalassemia disease is prevented if beta thal carriers do not have children with one another (if they have children together, some children will be normal, some carriers, and some have disease). The other, less desirable way, is to test fetuses during pregnancy and abort the fetuses who have beta thal major. ...Read moreSee 1 more doctor answer
The kidneys are paired organs that lie on either side of the vertebral column. Part of their critical functions include the excretion of urine and removal of nitrogenous wastes products from the blood. They regulate acid-base, electrolyte, fluid balance and blood pressure. Through hormonal signals, the kidneys control the ...Read more
Yes: It can definitely cause anemia in what we call anemia of inflammation. It is also known as anemia of chronic disease. The kidneys secrete an important hormone called erythopoetin which helps with the production of red blood cells. For this reason, you have anemia of chronic disease. You should definitely have iron studies drawn and see if you are a candidate for medication. ...Read more
Traits, yes: Because the Alpha and beta thalassemia gene mutations are common, it is possible for a baby to inherit one from mom and another from dad. The child could be "trait" in both Alpha and beta, or less likely, be "disease" in one and "trait" in the other. It is hard to imagine being "disease" in both and still survive. ...Read moreSee 1 more doctor answer
Electrophoresis, but: Levels of hemoglobin h and hemoglobin barts should make the distinction straightforward though there may be modifying genes that could make interpretation. The real question is the implications in planning your family and for this perhaps you would like to have genetic testing done. Any hematologist would probably enjoy helping you out. Good luck. ...Read more
In case of kidney transplant due to chronic kidney failure, which donated kidney is preferred: living related or living unrelated kidney?
Why sickle cell anemeia / multiple myeloma cause diabetes insipidus ? Is it because it may obstruct the blood flow to the kidneys and damage them?
Basically right: Even sickle cell trait ruins much of the concentrating ability of the kidneys by adulthood. Myeloma is more likely to damage and obstruct the tubules themselves. Both produce a kidney lesion that prevents the urine from becoming concentrated, rather than a pituitary diabetes insipidus. ...Read more
No: It affects red blood cells. Not white blood cells or any other component of the immune system. ...Read more
Can a carrier (heterozygote) of the wilson disease gene donate part of his/her liver tissue for a living related donor transplant to a patient?
Yes: Wilsons disease is a disease of copper storage. It is genetically linked. Generally speaking people who are heterozygous (are only carriers) can donate their part of thier livers. People who are heterozygous are carriers and don't have wilson's disease themselves. ...Read moreSee 1 more doctor answer
Renal disease: It depends on what type of kidney disease. ...Read more
Alpha-1 antitrypsin deficiency. Can this relate to high GGT in liver, breathing heart and lung issues, can it affect medications like ACE inhibitors
ACE: Is produced in the kidneys and lungs. A-1at deficiency affect the lungs and the liver to cause emphysema and cirrhosis. Due to lung problem, the heart can suffer and symptoms could include tachycardia and heart failure due to the emphysema. It also causes chronic cough. From this you can surmise that yes, GGT can be elevated and ace can decrease but kidney can produce enough. ...Read more
Not if just 1 trait: Having either beta thalassemia trait or sickle cell trait is a mild condition and should not cause symptoms to the point of making a person frequently ill nor shortening life expectancy. Having beta thalassemia major or sickle cell disease, or both sickle cell trait and beta thalassemia trait, usually causes severe enough chronic disease symptoms to shorten lifespan an uncertain amount. ...Read moreSee 1 more doctor answer
Molecular disease: Hi. Sickle cell anemia (SCA) was the FIRST described molecular basis of disease - very historic. The mutated hemoglobin gene makes a mutant hemoglobin protein called hemoglobin S (HbS). In low oxygen and/or acidic conditions, HbS is less soluble and precipitates in the red cell, producing the characteristic sickle shape of the red cell. Homozygous S/S get sick; heterozygous A/S resist malaria. ...Read moreSee 1 more doctor answer
Ace, would low levels would show with COPD and lung disease, could they relate to billary cirroshis of the liver ( autoimmune) Hib related meningitis?
The bad cells: In simplest terms, the sickle ("bad") cells need to be removed because they get "trapped" in the liver where they are disposed of. These cells don't live as long as normal red blood cells, so the liver is working over time. ...Read more
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