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Doctor insights on: Beta Globin Complete

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Cause of a positive monoclonal T cell beta gene rearrangement?

Cause of a positive monoclonal T cell beta gene rearrangement?

Tumor: Monoclonal proliferation of lymphoid cells is usually an indication of tumor of the lymphoid tissue. ...Read more

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What is sickle cell beta thalassemia?

What is sickle cell beta thalassemia?

Got both mutations: A person has sickle cell beta thalassemia if he inherited one gene mutation for sickle cell anemia, and also inherited one gene mutation for beta thalassemia. He can have symptoms of sickle cell disease, unlike patients with only sickle cell trait who are generally without symptoms. ...Read more

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Are hb s levels elevated with beta thalassemia trait?

Are hb s levels elevated with beta thalassemia trait?

No: With beta thalassemia trait alone, no hemoglobin s should be detected. If hemoglobin s is being detected in addition to beta thalassemia trait then the patient has a form of sickle cell beta thalassemia disease. ...Read more

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Is beta thalassemia major andd hb e/beta thalassemia same?

Is beta thalassemia major andd hb e/beta thalassemia same?

Not the same.: Hemoglobin e is found in the asian population frequently and may be seen with thal trait. Thal major is a serious problem requiring much intervention, including transfusions and frequently splenectomy. Your doctor should be your guiding you. Pregnancy needs to be discussed with your doctor. ...Read more

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Can an alpha thalassemia carrier marry a beta thalassemia carrier?

Can an alpha thalassemia carrier marry a beta thalassemia carrier?

Of course you can: A person can marry anyone they like. From a thalassemia perspective, and assuming your Alpha thal trait is in cis, your child has a 50/50 chance of being Alpha thal trait vs. Normal and a 50/50 chance of being beta thal trait vs. Normal. Given there is consideration of inheriting two distinct trait states, it would be prudent to sit with a genetic counselor to understand the implications clearly. ...Read more

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Blood flow cytmtry shows dual positive cd4cd30 cells absolute count of 2354. IGG slightly elevated with elevated light chains, T cell Beta clone noted?

Blood flow cytmtry shows dual positive cd4cd30 cells absolute count of 2354. IGG slightly elevated with elevated light chains, T cell Beta clone noted?

Asking what?: If your are requesting a diagnosis online, this is not the appropriate venue. Though the flow cytometry results are not totally normal, your results should be reviewed with the physician who ordered it. This format does not give us the ability to determine if your clinical presentation and lab results are consistent with a specific diagnosis. ...Read more

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Monoclonal T cell beta gene rearrangement in blood /normal CBC / ANA / CMP / high Uric acid. Bouts of itching and hives. Significance?

Monoclonal T cell beta gene rearrangement in blood /normal CBC / ANA / CMP / high Uric acid. Bouts of itching and hives. Significance?

?: Can still be chronic idiopathic urticaria, but other lab tests need to be performed as well: thyroid function tests, thyroid antibodies, complement levels, stools analysis, etc.. also other pieces of history need to be known, better see an allergist, check aaaai.org or acaai.org for an allergist in your area, meanwhile keep taking whatever antihistaminic on regulat basis, good luck ...Read more

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What causes hemoglobin E-beta thalassemia?

What causes hemoglobin E-beta thalassemia?

Thalassemia : This is a genetic hemolytic blood disorders transmitted to you from your parents in your genes & instead of having the normal Hgb A, it becomes abnormal Hgb. there are different types of thalassemia. If both parents are carriers or have the disease then the offspring might get the disease. I hope this helps. Good luck. ...Read more

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Does alpha thalassemia trait have gene therapy available?

Does alpha thalassemia trait have gene therapy available?

No: Alpha thalassemia trait only causes mild anemia, and the person usually has no symptoms. Gene therapy is not available and would not be needed. ...Read more

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What chromosome carries the gene for sickle cell anemia?

What chromosome carries the gene for sickle cell anemia?

Chromosome No. 11: Point mutation at beta-globin gene located at chromosome no. 11 results in production of defective hemoglobin, sickle hemoglobin. ...Read more

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Beta thalesemic carrier state...Meaning?

Beta thalesemic carrier state...Meaning?

Genes: To have beta thalessemia, you have to have 2 copies of a particular gene. If you only have 1 copy, you don't have the disease, but you do carry the trait, and can pass it to your children. If your partner also is a carrier of the gene, then there is a 1 in 4 chance that your child will have beta thalessimia. ...Read more

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How does one test for sickle beta thalassemia?

Blood test: Sickle Beta cell Thalassemia is an inherited disorder and new born screening is available and should be done . This disorder is due to decreased synthesis or absence of beta globulin chains . It may manifest in infancy and early childhood and may cause serious medical problems which need to be treated ...Read more

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Why is hemoglobin hplc/ electrophoresis, blood done?

Why is hemoglobin hplc/ electrophoresis, blood done?

Variant hemoglobins: These tests are done to detect variants of hemoglobin as some of the variants, such as hemoglobin s, cause medical problems. Some states require all pregnant women be tested for hemoglobin variations as part of the antenatal care. ...Read more

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How to differentiate between alpha thalassaemia trait and hb h disease without a genetic test?

How to differentiate between alpha thalassaemia trait and hb h disease without a genetic test?

Electrophoresis, but: Levels of hemoglobin h and hemoglobin barts should make the distinction straightforward though there may be modifying genes that could make interpretation. The real question is the implications in planning your family and for this perhaps you would like to have genetic testing done. Any hematologist would probably enjoy helping you out. Good luck. ...Read more

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Do beta thalassemia and sickle cell anemia always reduce life expectancy?

Do beta thalassemia and sickle cell anemia always reduce life expectancy?

Not if just 1 trait: Having either beta thalassemia trait or sickle cell trait is a mild condition and should not cause symptoms to the point of making a person frequently ill nor shortening life expectancy. Having beta thalassemia major or sickle cell disease, or both sickle cell trait and beta thalassemia trait, usually causes severe enough chronic disease symptoms to shorten lifespan an uncertain amount. ...Read more

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Is alpha2 and alpha 2 macroglobulin the same blood test?

Is alpha2 and alpha 2 macroglobulin the same blood test?

Blood Tests: There are. Few more Alpha 2's in the blood that can be tested. One of those is Alpha2 macro globulin. You doctor should specify what he/she wants done, depending on the diagnosis, so the lab can do the proper tests. ...Read more

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Does alpha thalassemia causes leukemia?

Does alpha thalassemia causes leukemia?

No: Alpha and beta thalassemia have not been reported to cause leukemia, which is cancer of the white blood cells. There is a study of beta thal. Major & intermedia patients in iran, where researchers found 5 leukemia cases in about 4, 600 patients. That is a higher rate of leukemia than in the general population there, but details were unavailable as to what other factors were present in the patients. ...Read more

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