Doctor insights on:
Best Cml Treatment
High deductible. Limited coverage of outpatient care. Would really help to know what tests, evaluations are required to diagnose chronic myelogenous leukemia and follow it after treatment.?
Nccn.org: Awful predicament. CML is one of the success stories with the new therapies, but proper follow up is important to assure optimal long term survival on the new oral agents. There are good patient assistance programs to assist with your medications. Review the web address above and CML page with your doc to plan the needed tests. ...Read more
Multiple: There are medications called tyrosine kinase inhibitors. They block this enzyme and treat the leukemia. There are currently three on the market, imatinib, nilotinib and dasatinib. Other treatments include bone marrow transplant but rarely done now because these medications are available. Hope this helps. ...Read moreSee 1 more doctor answer
I live in a college town with many healers who use Asian treatments. Will they work on chronic myelogenous leukemia?
Chr myeloid leukemia: CML can cause high white count with white cells in different stages of maturation, anemia and high platelet count. Fatigue, abdominal pain, early satiety from splenomegaly, bleeding diathesis, risk of infection, usually blood tests and bone marrow biopsy establishes diagnosis by virtue of having a philadelphia chromosome abnormality (translocation 9:22). Disease is highly treatable with oral drugs. ...Read more
No: More of a targeted therapy. Unlike chemotherapy which does not have a target, Gleevec or imatinib does have a target. It blocks a tyrosine kinase which prevents certain protein development needed for cancer growth. So more of what is called a biologic therapy. Hope this helps. ...Read moreSee 1 more doctor answer
I have cml and have responded well to treatment. I am 55and my brother is 57. Is there an age when a marrow transplant is not viable. ?
CML & transplant: You need to have therapeutic failure to tyrosine kinase inhibitors (gleevec, nilotinib, dasatinib) to be considered for sct (stem cell transplant). Age wise sct can be done upto age 70 in patients who have good end organ functions and physically fit. In most cases, results of these oral drugs are so impressive that sct is falling out of favor as it can have serious side effects & morbidity. ...Read moreSee 2 more doctor answers
My wife is a cml patient (blood cancer) She is under medication with imelek 400(sun pharma). Other treatments?
Imatinib: There are several options: Imatinib, Nilotinib, Dasatinib. These 3 are options for First and second line treatment. Other ones are Bosutinib, ponatinib, Omacetaxine. Hope this helps. ...Read more
Pcr-FISH-karyotype: There are 3 main types of genetic tests. The old standard is to take a blood sample from the hip (marrow) and grow cells to look at all the chromosomes (karyotype). It is a 'broad strokes' look but not as sensitive as the others. A fish test looks at blood cells with 'probes' to the known genetic changes (moderately sensitive) and a PCR test is a 'molecular' test of the dna (very sensitive). ...Read moreSee 1 more doctor answer
White cell cancer: The bone marrow cells that produce granulocytes (needed to fight infections) grow out of control and are present in large numbers in the blood and other organs. The disease is quite treatable these days because of targeted therapy and long lasting remissions are possible in most people. ...Read moreSee 1 more doctor answer
Bcr-abl: CML is a clonal disorder (cancer) of the white blood cells in the blood (= -emia part). Other leukemias include cll, aml, all, etc. CML is often diagnosed by testing on peripheral blood or bone marrow. The bcr-abl translocation (philadelphia chromosome) is found in cml. Treatment may be a variety of pills. The most common initial treatment has been gleevec (imatinib). Other drugs are available. ...Read more
A blood cancer: CML is a blood cancer that develops slowly (hence chronic). If untreated it will eventually be life threatening. It is associated a unique chromosomal injury, the philadelphia chromosome. New drugs (tkis) target this damage and reliably produce remissions in early stage patients that often are long lasting. ...Read moreSee 1 more doctor answer
Can be fatal: This is a disease that was associated with a shortened life span. The discovery of a specific cancer cell mutation and medications that attack that mutation have dramatically affected the outcome. This is now a disease that people can live for many years and be functional and productive. ...Read more
By oncologist: This is a somewhat indolent form of leukemia which responds to treatment and can be carried for many years without major illenss. You could only have known about this if you had a bone marrow and blood test from your oncologist whose recommendations i would continue to follow. ...Read moreSee 2 more doctor answers