Doctor insights on:
Best Acromegaly Program
Failed 5 IGF-1/acromegaly tests from 2% to 25% over upper normal range. is GH suppression test or dynamic pituitary MRI best nest step?
First confirm dx: Before imaging a dx of acromegaly should be confirmed with a growth hormone suppression test. Only after the biochemical diagnosis of the pituitary disease is made should imaging be done. There are other reasons for pituitary abnormalities, including nonfunctional pituitary adenomas. Iit would be a shame to have abnormal imaging and an extensive work up only to find that the dx is not correct! ...Read more
IGF-1, MRI, others: A screening test is igf-1 (or insulin-like growth factor). This test is more reliable than growth hormone (gh) because gh is released in pulses, so that a one-time measurement of gh doesn't mean much. If the igf-1 is high, further tests may include a test where glucose is given & gh check to see if if suppresses (normal) or stays high (acromegaly) and MRI is done to check for pituitary tumor. ...Read more
Excess growth hormon: It is caused by a pituitary tumor that produces growth hormone. In children, it causes gigantism, but when it happens after growth has stopped, it causes acromegaly. There can be enlargement if the jaw and forehead. It can cause high blood pressure, joint pain, skin tags, excess sweating, a goiter. It increases the risk of certain cancers. It is generally treated with surgery. ...Read moreSee 1 more doctor answer
Many: Adults do not gain height once the bones are completely mineralized, but the bones can grow in width. So wider hands or feet are classic symptoms. Facial bones may enlarge and lead to coarsening of facial features; the jaw may enlarge and protrude. People with acromegaly may also have headaches, diabetes, sleep apnea, heart problems, carpal tunnel, arthritis, & higher risk for cancer. ...Read more
Acromegaly: Acromegaly is abnormal soft tissue growth from excessive growth hormone production by a pituitary tumor. A change in glove or shoe size can be the earliest sign. Some people notice a change in the spacing of their teeth, perhaps requiring braces in adulthood. Others notice gradual change in appearance, with enlargement of the nose, ears, lips, face or tongue, overgrowth of the jaw or brow. ...Read more
Check IGF-1: Hi. If we suspect acromegaly on clinical grounds, we check an IGF-1 (and I also get an IGFBP-3); I get a GH, but it's seldom helpful at the screening stage). If IGF-1 is elevated, then a growth hormone suppression test is done. If that's abnormal, we then do a pituitary MRI. Acromegaly tumors are usually big and easy to see. Good luck! ...Read more
Acromegaly: You do not say why you think you have this relatively rare disease. You should see your doctor about this. An endocrinologist is a specialist in gland disorders and would be in the best position to work this up. ...Read more
Acromegaly : Hi. Treating acromegaly is a multi-pronged approach. The first step is almost always surgery, however surgery is often not curative. Subsequent lines of treatment include somatostatin analogs (e.g., lanreotide) and maybe the GH receptor antagonist, pegvisomant. Sometimes pituitary radiation is necessary. Good luck! ...Read more
Acromegaly: Acromegaly causes overgrowth of many bones including the skull, face and limbs due to an excess of growth hormone, usually caused by a pituitary tumor. When the disease is properly treated (with surgery), there will be partial but not complete improvement in the peculiar appearance due to overgrown bones; there will be more marked improvement in the aches and pain of acromegaly. ...Read more
Is it true that 30-somethings with acromegaly WON'T grow any taller @ this age? Is that true even for those with just mild symptoms of the disease?
It Depends: If you got acromegaly as an adult after growth stopped this is true. However, if not treated there can be serious side effects (hearing loss, chronic headaches, arthritis, type 2 DM & others). If it was acquired as a child & not treated this is correctly termed Pituitary Gigantism & can have same symptoms. In this case the growth plates may remain open & cont growth theoretic poss, but very rare! ...Read moreSee 1 more doctor answer
What would cause out of blue growth spurts (2-3 in. In height) at 38, after being same height since early 20s? No other phys changes; no acromegaly.
Growth spurt age 38: 1. you are now wearing high heels? 2. someone snuck lifters into your shoes? 3. Your measuring tape has shrunk? 4. The Dr has changed offices and his measuring thing was misplaced on wall. ...Read more
I know acromegaly can cause added height in adulthood. But what other conditions/issues could add 2 or more inches after 38 w/.no other phys changes?
Acromegaly: does not cause significant height growth, because following puberty the growth plates are closed and there is limited ability to grow in length. If there is excess growth hormone in childhood, before growth plates close, there can be abnormally increased height, but it is called gigantism, not acromegaly. ...Read more
Read 3 online claims of indivs growing b/w 1.5-4 inches @ ages 33, 37, 41. Does it really happen so late in life?If not acromegaly then what is cause?
Acromegaly would be: the cause. People stop growing when they are in their early 20's, in general. Someone who is 41 and continues to grow has an endocrine problem,maybe an excess of growth hormone or receiving shots of GH. I would be careful to describe this as normal. Maybe they need the services of an Endocrinologist.. I hope this helps. ...Read more
Are there any other conditions besides acromegaly that would bring on several sudden growth spurts (sev inchs) of height in adults near & past age 40?
Growth: Well before age 40 epiphyses get closed and vertical growth is not possible by any means. ...Read more