Doctor insights on:
Benign Tumors Neurofibromatosis
A tumor by any other name is a growth. It can be either benign or malignant, differentiated based upon the potential to spread (a malignant tumor is, by definition, a cancer). The best way to determine this is by a tissue biopsy, but we can make better predictions based on the organ of origin, physical ...Read more
Yes: All tumors arise from normal pre existing cells that have undergone some form of transformation. Several oncogenes are turned on to present the benign as well as malignant lesion with immortality. In the case of the malignant tumor additional changes allow for matrix metalloproteinase to be produced to dissolve walls of blood vessels for metastasis and convert e-cadherin to small e cad. ...Read more
Depends on situation: There is a middle ground between the common idea of benign (never harmful) and malignant (always harmful). Conditions like tuberous sclerosis can generate tumors that become destructive because of there location, like in the brain or heart. They don't have to travel there like some cancers, they can just pop up anywhere ; interfere with normal tissue. ...Read more
Some are: Teratomas arise from cells that can differentiate in to a host of tissue types and can be associated with chromosomal (genetic) abnormalities or with inherited syndromes. However, vast majority are sporadic and will not be passed on to the kids. ...Read more
Are carcinoid tumors carcinoma? Is malignant metastatic stomach carcinoma that's hereditary a carcinoid cancer? carcinoid Neuroendocrine tumors?
Depends: A thymoma is a malignant tumor of the thymus, and the seriousness depends on details in the pathology report. An ectopic thymus and a hamartoma are both benign, but if the report says "thymoma" then it is probably malignant although not necessarily very serious if completely removed. Discuss with your surgeon! ...Read moreSee 1 more doctor answer
No.: By definition, a benign tumor does not metastasize (spread to other sites by invading the blood stream or lymphatic system). Extremely rare cases of 'parasitic' or implanted benign tumors (eg leiomyomas of the uterus) are recognized to occur in sites outside their normal origin, but this is thought to be a result of some form of tissue transplantation, and not true tumor ''metastasis' ...Read more
If both benign and malignant tumours are formed by abnormal cell division, what makes malignant tumours cancerous and benign tumours non-cancerous?
Power to invade: Tumors are in fact caused by the accumulation of a series of genetic mutations. If something is going to be cancer, the mutations destabilize the genome and eventually mutations give the ability of the cells to invade and spread as they do early after conception. The idea that tumors are "cells dividing too rapidly" is fundamentally wrong and confusing -- it's the loss of controls. ...Read more
Yes: Many benign tumors are known to convert to malignancy and are carefully watched and not subject to treatment ie giant cell tumor of bone that is radiated will convert. Benign lipomas as they grow may be found to convert to liposarcoma and Pagets of bone is known to convert to Pagets sarcoma.Thyroid adenomas also have a high rate of conversion. ...Read more
Terminology issues: The term malignant is used to describe a tumor known to spread to & damage tissues & organs to the point death is possible. Benign tumors are less worrisome.They tend not to spread, but someone may have many individual ones.Their location & growth may produce problems for the patient.Transformation to a malignancy in unheard of for some benign lesions and rare for others. ...Read more
0%: All ependymoma brain tumors are technically malignant, meaning the cells are cancer and can grow into the surrounding brain tissue. However, most of these tumors (over 90%) are curable because the tumor is confined to one area, is slow-growing, and can be removed by surgery. Sometimes radiation alone is used for slow-growing brain ependymomas if surgery can't be performed. ...Read moreSee 1 more doctor answer
MFH: Malignant fibrous histiocytoma is an umbrella term used to describe a range of more specific sarcomas. Although many of these tumors have unique cytogenetic profiles, they are largely not hereditary. ...Read more