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Doctor insights on: Bence Jones Protein

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Is bence jones protein different from regular protein in urine?

Is bence jones protein different from regular protein in urine?

Yes: Usually, Albumin or a mix of proteins are the stuff in "proteinuria". Bence-jones is immunoglobulin light chains and is much more worrisome. It also often doesn't show on the urine dipsticks that are the usual screen for proteinuria. ...Read more

Protein (Definition)

Proteins are large molecules made up of a smaller class of molecules called amino acids. Proteins play an enormous role in the function of our bodies including enzymes, messengers, replicating dna, ...Read more


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KL FLC chains to rule out light chain myeloma? No m spike in serum or 24-hr urine, but lambda bence jones in spot urine but md didnt order urine ifa?

KL FLC chains to rule out light chain myeloma? No m spike in serum or 24-hr urine, but lambda bence jones in spot urine but md didnt order urine ifa?

Does not add up: How do you know it was lambda bence jones in urine without a urine IFA? This issue is not suitable for this forum as a diagnosis of myeloma requires results of other tests as well, e.g., bone X-ray, bone marrow examination, serum calcium and beta 2 microglobulin levels etc. It would be prudent to discuss the matter with a hematologist. ...Read more

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Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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In protein's electrophoresis Is polyclonal gammopathy alway pathological? Thanks

In protein's electrophoresis Is polyclonal gammopathy alway pathological? Thanks

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, What is total gamma globulin level? If it is more than 2.0 gm/dL it needs to be evaluated. There are many causes of polyclonal gammopathy., and some of those are serious. ...Read more

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High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio.No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer?Normal WBC

High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio.No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer?Normal WBC

I bet it's nothing: Without free light chains or a monoclonal protein in blood or urine, the ratio's meaningless. And like most lab tests, the reference range is set so that a few percent of healthies fall outside on either end. ...Read more

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Ana positive 160 with lambda bj protein in urine (total 2 gm/day). Diabetic ckd r/o myeloma. Creatinine 1.5-2.6 variable. Hem unaware of lcdd. Steps?

Ana positive 160 with lambda bj protein in urine (total 2 gm/day). Diabetic ckd r/o myeloma. Creatinine 1.5-2.6 variable. Hem unaware of lcdd. Steps?

Multiple myeloma: Multiple myeloma diagnosis needs more information, need the hemoglobin level, calcium level, need serum immunoglobulin level and urine BJ protein of course. Some times you may need a bone marrow biopsy for the confirmation of the diagnosis. You need to see an Oncologist/Hematologist ...Read more

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Rule out light chain myeloma without biopsy or amyloidsis with fat biopsy? Spot urine lambda bence jones, no m spike in serum or urine. Next 24hr ufe?

Rule out light chain myeloma without biopsy or amyloidsis with fat biopsy? Spot urine lambda bence jones, no m spike in serum or urine. Next 24hr ufe?

Urine light chains: hello~ thats an impossible question for me to answer here. My brain will overheat if I have to do that in 421 words. Be kind to us. Please go and see an Oncologist or a smart general internist and he will answer or even manage your case. Remember that not all light chains in the urine means myeloma. See an expert and have him explain the difference between MGUS and myeloma.thanks ...Read more

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Serum protein electrophoresis - hight beta fraction, what does this mean?

Serum protein electrophoresis - hight beta fraction, what does this mean?

Unimportant: Tell us your values of all proteins. The only two that matter are Albumin and Gamma Globulin. A M spike(monoclonal peak) can be abnormal...so look for this, otherwise you are ok and can ignore the beta fraction. ...Read more

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Hemoglobin 8.4, kft, anemia profile, protein electroph, iron, b12, folate, (folic acid) m protein - all normal. Kappa lambda ratio 2.96 - means ?

Hemoglobin 8.4, kft, anemia profile, protein electroph, iron, b12, folate, (folic acid) m protein - all normal. Kappa lambda ratio 2.96 - means ?

?Find cause for Anem: You have anemia for which your doctors should find a cause. This requires doing a variety of tests which a good physician or a hematologist(blood specialist) can do. Unless already done, you need an examination of your bone marrow and more tests till we find the cause of your anemia. The light chains may be hinting at a possible cause which can be checked further with a bone marrow examination. ...Read more

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Adnorm. Blood & cfs results: high: CSF protein-47, high cfs albumin-30.9; low total protein-5.7, low gamma globulin-.5, low IgG quantitative -621 worry?

Adnorm. Blood & cfs results: high: CSF protein-47, high cfs albumin-30.9; low total protein-5.7, low gamma globulin-.5, low IgG quantitative -621 worry?

CSF: Some experts consider CSF protein levels to be normal if the value is equal to or below your age in years. I don't think in your case there is a reason to worry. Other CSF components are important as well. Check with your physician to see if there is any reasons to worry. Hope you feel well soon. ...Read more

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Can you interpret, squam epi cells few a, alpha 2 protein 1.01 h, possible faint IgM lambda monoclonal protein present, ACE serum 75 h?

No: Can't interpret random blood test results without context. Talk to the doctor that ordered the tests. Most medical tests (x-rays, blood tests, etc., ) are better at telling us what you don't have rather than diagnosing what (if anything) you do have wrong with you. ...Read more

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Blood test protein ua 50 mg/dl. Is it too high?

Blood test protein ua 50 mg/dl. Is it too high?

Uric acid: There is generally no problem with an elevated uric acid level and no reason to treat, UNLESS a person has been diagnosed with Gout. In that case, medication would be given to keep the UA in a normal range. Otherwise, it does not need to be treated. ...Read more

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Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Clinical context : The use of light chains is limited in diseases other than monoclonal gammopathies, such as myeloma or amyloidosis. If this is the context that yours got checked the results do not suggest such a condition. With no gammopathy suggested by results the question regarding clonality has no grounds. As any other test, trending the results would help in integrating it in a meaningful clinical context. ...Read more

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Kappa light chain in upep. Elevated k/l chains in serum but ratio normal. Wbc, rbc in urine with 2g/d protein. More/which workup/specialist needed?

Kappa light chain in upep. Elevated k/l chains in serum but ratio normal. Wbc, rbc in urine with 2g/d protein. More/which workup/specialist needed?

Nephrologist: You need a nephrologist to follow up on those tests, but your doctor or the doctor who ordered those tests can direct you better, wish you wellness ...Read more

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Protein Total Serum 8.7 Globulin Serum 4.20 Albumin/ Globulin Ratio 1.07 ALP 132 Urea/ CreatinineRatio 18.54 rest normal . Any worries here ?

 
Protein Total  Serum  8.7
Globulin Serum 4.20
Albumin/ Globulin Ratio 1.07
ALP  132
Urea/ CreatinineRatio 18.54
rest normal . Any worries here ?

Need more info.: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, there is no immediate concern, however, your globulin level may be higher than normal and you should discuss it with the doctor who ordered the tests. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more